Novel thiosemicarbazide-based β-carboline derivatives as α-glucosidase inhibitors: Synthesis and biological evaluation

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 275, P. 116595 - 116595

Published: June 12, 2024

Language: Английский

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Astragali Radix: comprehensive review of its botany, phytochemistry, pharmacology and clinical application

Archives of Pharmacal Research, Journal Year: 2024, Volume and Issue: 47(3), P. 165 - 218

Published: March 1, 2024

Language: Английский

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Targeting MAPK-ERK/JNK pathway: A potential intervention mechanism of myocardial fibrosis in heart failure

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 173, P. 116413 - 116413

Published: March 9, 2024

Myocardial fibrosis is a significant pathological basis of heart failure. Overactivation the ERK1/2 and JNK1/2 signaling pathways MAPK family members synergistically promotes proliferation myocardial fibroblasts accelerates development fibrosis. In addition to some small molecule inhibitors Western drugs, many Chinese medicines can also inhibit activity JNK1/2, thus slowing down fibrosis, are generally safe effective. However, specific biological mechanisms in still need be fully understood, there no systematic review existing drugs methods them from improving This study aims summarize roles cross-linking systematically sort out small-molecule inhibitors, traditional medicines, non-pharmacological therapies that alleviate future, we hope conduct more in-depth research perspective precision-targeted therapy, using this as for developing new provide perspectives on prevention treatment

Language: Английский

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RG-I pectin-like polysaccharide from Rosa chinensis inhibits inflammation and fibrosis associated to HMGB1/TLR4/NF-κB signaling pathway to improve non-alcoholic steatohepatitis

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 337, P. 122139 - 122139

Published: April 8, 2024

Language: Английский

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Regulatory effects of Astragalus membranaceus polysaccharides on lipid metabolism disorders induced by a high-fat diet in spotted sea bass (Lateolabrax maculatus)

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 271, P. 132584 - 132584

Published: May 23, 2024

Language: Английский

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Pharmacological effects of Astragalus polysaccharides in treating neurodegenerative diseases

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 2, 2024

widely used in traditional Chinese medicine, exhibits multiple pharmacological effects, including immune stimulation, antioxidation, hepatoprotection, diuresis, antidiabetes, anticancer, and expectorant properties. Its main bioactive compounds include flavonoids, triterpene saponins, polysaccharides. Astragalus polysaccharides (APS), one of its primary components, have been shown to possess a variety activities, such as antioxidant, immunomodulatory, anti-inflammatory, antitumor, antidiabetic, antiviral, hepatoprotective, anti-atherosclerotic, hematopoietic, neuroprotective effects. This review provides comprehensive summary the molecular mechanisms therapeutic effects APS treating neurodegenerative diseases, Alzheimer's disease (AD), Parkinson's (PD), sclerosis (MS). It discusses how improve insulin resistance, reduce blood glucose levels, enhance cognitive function, Aβ accumulation neuronal apoptosis by modulating various pathways Nrf2, JAK/STAT, Toll, IMD. For PD, protect neurons stabilize mitochondrial function inhibiting ROS production promoting autophagy through PI3K/AKT/mTOR pathway. also oxidative stress neurotoxicity induced 6-hydroxydopamine, showcasing their In MS, alleviate symptoms suppressing T cell proliferation reducing pro-inflammatory cytokine expression via PD-1/PD-Ls promote myelin regeneration activating Sonic hedgehog signaling pathway fostering differentiation neural stem cells into oligodendrocytes. article emphasizes significant activities APS, highlighting potential promising candidates for treatment diseases.

Language: Английский

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Parabacteroides goldsteinii enriched by Pericarpium Citri Reticulatae ‘Chachiensis’ polysaccharides improves colitis via the inhibition of lipopolysaccharide-involved PI3K-Akt signaling pathway

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 133726 - 133726

Published: July 31, 2024

Language: Английский

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Extraction, Purification, Sulfated Modification, and Biological Activities of Dandelion Root Polysaccharides

Foods, Journal Year: 2024, Volume and Issue: 13(15), P. 2393 - 2393

Published: July 29, 2024

In this study, polysaccharides were extracted at a rate of 87.5% ± 1.5% from native dandelion roots, and the root (DRPs) then chemically modified to obtain sulfated (SDRPs) with degree substitution 1.49 0.07. The effects modification conditions, physicochemical characterizations, structural characteristics, antioxidant properties, hypoglycemic activity, proliferative on probiotics DRP derivatives further investigated. Results showed that optimum conditions for sulfation DRPs included esterification reagents (concentrated sulfuric acid:

Language: Английский

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Structural characterization of an inulin neoseries-type fructan from Ophiopogonis Radix and the therapeutic effect on liver fibrosis in vivo

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 327, P. 121659 - 121659

Published: Dec. 4, 2023

Language: Английский

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Kluyveromyces marxianus supplementation ameliorates alcohol-induced liver injury associated with the modulation of gut microbiota in mice

Food & Function, Journal Year: 2023, Volume and Issue: 14(21), P. 9920 - 9935

Published: Jan. 1, 2023

Kluyveromyces marxianus may ameliorate alcoholic liver injury by restoring the gut barrier and dysbiosis, reducing LPS leakage, inhibiting hepatic oxidative stress inflammation in mice.

Language: Английский

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