Research Progress on the Chemical Constituents and Pharmacological Effects of Houttuynia cordata Thunb and a Predictive Analysis of Quality Markers DOI Creative Commons

Zhuo Yang,

Peng Ji, Chenchen Li

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 47(1), P. 18 - 18

Published: Dec. 31, 2024

Houttuynia cordata (H. cordata) is widely used in respiratory disease control as an important heat-clearing and detoxifying traditional Chinese medicine. It effectively clears away heat toxins, eliminates carbuncles, drains pus, it diuretic detoxicating. The aim of this study to review the botany, chemical composition, pharmacological effects, quality H. establish a better-quality evaluation system. Google Scholar, Baidu PubMed, ScienceDirect, Web Science, multiple databases, including China National Knowledge Infrastructure (CNKI) Wanfang Data, were searched. A structural diagram compound was drawn using ChemDraw software. contains volatile oils, flavonoids, alkaloids. has antibacterial, anti-inflammatory, antiviral, antioxidant, antitumor, immunity-enhancing effects. By analyzing literature, predicted that sodium, methyl nonyl ketone, quercetin, quercitrin could be markers (Q-marker) cordata. This provides basis for further research into applications

Language: Английский

Houttuynia cordata-Derived Exosome-Like Nanoparticles Mitigate Colitis in Mice via Inhibition of the NLRP3 Signaling Pathway and Modulation of the Gut Microbiota DOI Creative Commons
Jianhong Li, Jing Xu, Chen Huang

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 13991 - 14018

Published: Dec. 1, 2024

Plant-derived exosome-like nanoparticles (PELNs) have received widespread attention in treating ulcerative colitis (UC). However, the role of Houttuynia cordata-derived (HELNs) UC remains unclear. This study aims to evaluate efficacy HELNs mice and investigate its potential mechanisms. were isolated from H. cordata for characterization, their safety stability evaluated. A dextran sulfate sodium (DSS)-induced mouse model was utilized assess therapeutic UC. In vivo, imaging flow cytometry targeting effect on inflamed colonic sites modulation immune environment. RNA-seq analysis molecular docking performed identify pathways recruited by HELNs. Guided transcriptomic findings, NLRP3-/- used conjunction with Western blotting, qPCR, immunofluorescence, other techniques verify that alleviated DSS-induced inhibiting NLRP3/NOD-like receptor signaling pathways. Lastly, impact gut microbiota investigated through 16S rRNA sequencing. significantly reduced severity mice, alleviating symptoms histopathological damage. Furthermore, can specifically target colon tissue, regulate environment, decrease inflammation. analysis, coupled use demonstrated inhibited balanced composition colitis, decreasing abundance harmful bacteria increasing beneficial intestinal tract these mice. summary, exhibit protect damage pathway modulating microbiota, presenting a promising option management

Language: Английский

Citations

4
Houttuynia cordata thunb. alleviates inflammatory bowel disease by modulating intestinal microenvironment: a research review DOI Creative Commons
Si Wang,

Lei Li,

Yuhan Chen

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 22, 2023

Inflammatory bowel disease (IBD) is a complex group of chronic intestinal diseases, the cause which has not yet been clarified, but it widely believed that disorder microenvironment and its related functional changes are key factors in development disease. Houttuynia cordata thunb. traditional plant with abundant resources long history utilization China, attracted widespread attention recent years due to potential treatment IBD. However, limited owing aristolochic acid alkaloids contained it. Therefore, based on relationship between IBD, this article summarizes mechanisms by main active ingredients thunb., such as volatile oils, polysaccharides, flavonoids, Chinese medicine preparations, Xiezhuo Jiedu Formula, alleviate IBD regulating microenvironment. At same time, combined current reports, medicinal edible safety explained for providing ideas further research chordate disease, more options patients, insights into therapeutic plants homology food even diseases.

Language: Английский

Citations

9
Passive RFID integrated acetone sensor and ammonia sensor based on LaFeO3/ZnO/rGO composites DOI
Bairui Tao,

Jianing Bai,

Fengjuan Miao

et al.

Microchemical Journal, Journal Year: 2024, Volume and Issue: 207, P. 112122 - 112122

Published: Nov. 6, 2024

Language: Английский

Citations

2
Endogenous Antimicrobial Substances in <i>Houttuynia cordata</i> and Their Application against <i>Ralstonia solanacearum</i> DOI

洪郝 张

Hans Journal of Agricultural Sciences, Journal Year: 2024, Volume and Issue: 14(06), P. 729 - 739

Published: Jan. 1, 2024

Language: Английский

Citations

0
The comprehensive evaluation and mechanism of HOUTTUYNIA CORDATA (Thunb) injection as a complementary therapy for infantile pneumonia DOI Creative Commons
Jincheng Du,

Shibin Tian,

Mengyue Liu

et al.

Phytomedicine Plus, Journal Year: 2024, Volume and Issue: 4(4), P. 100619 - 100619

Published: Aug. 15, 2024

Language: Английский

Citations

0
Process optimization, quality evaluation, and dynamic changes of metabolites in Houttuynia cordata yogurt DOI Creative Commons
Yuan Ma, Lu Long, Yan You

et al.

LWT, Journal Year: 2024, Volume and Issue: unknown, P. 116783 - 116783

Published: Sept. 1, 2024

Language: Английский

Citations

0
Chemical profiling and anti-inflammatory effect of phenolic extract of Gentiana rigescens Franch. DOI
Qiao Gao, Liang Li, Zhong Yao

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 119115 - 119115

Published: Nov. 1, 2024

Language: Английский

Citations

0
Research Progress on the Chemical Constituents and Pharmacological Effects of Houttuynia cordata Thunb and a Predictive Analysis of Quality Markers DOI Creative Commons

Zhuo Yang,

Peng Ji, Chenchen Li

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 47(1), P. 18 - 18

Published: Dec. 31, 2024

Houttuynia cordata (H. cordata) is widely used in respiratory disease control as an important heat-clearing and detoxifying traditional Chinese medicine. It effectively clears away heat toxins, eliminates carbuncles, drains pus, it diuretic detoxicating. The aim of this study to review the botany, chemical composition, pharmacological effects, quality H. establish a better-quality evaluation system. Google Scholar, Baidu PubMed, ScienceDirect, Web Science, multiple databases, including China National Knowledge Infrastructure (CNKI) Wanfang Data, were searched. A structural diagram compound was drawn using ChemDraw software. contains volatile oils, flavonoids, alkaloids. has antibacterial, anti-inflammatory, antiviral, antioxidant, antitumor, immunity-enhancing effects. By analyzing literature, predicted that sodium, methyl nonyl ketone, quercetin, quercitrin could be markers (Q-marker) cordata. This provides basis for further research into applications

Language: Английский

Citations

0