Journal of Pharmaceutical Analysis, Journal Year: 2024, Volume and Issue: 15(4), P. 101121 - 101121
Published: Oct. 18, 2024
Language: Английский
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Jan. 30, 2024
Rheumatoid arthritis (RA) and postmenopausal osteoporosis (PMOP) are common bone-immune diseases. The imbalance between helper (Th17) regulatory T cells (Tregs) produced during differentiation of CD4 + plays a key role in bone remodelling disorders RA PMOP. However, the specific mechanism this PMOP has not been clarified. Identifying underlying Th17/Treg represents factor research development new drugs for immune In review, potential roles Th17, Treg, regulating have summarised, mechanisms by which probiotics, traditional Chinese medicine compounds, monomers maintain balance expounded. maintenance could be considered as an therapeutic alternative treatment This study also summarizes advantages disadvantages conventional treatments quality life rehabilitation patients with findings presented her will provide better understanding close relationship immunity chronic diseases ideas future research, prevention,
Language: Английский
Citations
11
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 26, 2025
Ulcerative colitis (UC) is an autoimmune disease with incompletely understood pathogenesis. The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway plays a key role in immune response inflammation. More more studies demonstrated that JAK/STAT associated the pathogenesis UC. affects UC multiple ways by regulating intestinal inflammatory response, affecting mucosal barrier, modulating T cell homeostasis, macrophages. Encouragingly, natural products are promising candidates for treatment Natural have advantage being multi-targeted rich therapeutic modalities. This review summarized research progress pathway-mediated Furthermore, latest on targeting were systematically summarized, including active ingredients such as arbutin, aloe polysaccharide, berberine, matrine, curcumin, Ginsenoside Rh2, so on. aim this paper to provide new ideas drug development regulate treating
Language: Английский
Citations
1
Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14
Published: Oct. 24, 2023
Damage to the intestinal mucosal barrier play an important role in pathogenesis of ulcerative colitis (UC). Discovering key regulators and repairing disturbed are crucial for preventing treating UC. Traditional Chinese medicine (TCM) has been proved be effective on UC exhibited its barrier. We summarized evidence TCM against by protecting physical barrier, chemical immune biological Mechanisms increasing epithelial cells, tight junction proteins, mucins, promoting stem cell proliferation, restoring abundance microbiota, modulating innate adaptive immunity gut, were all involved in. Some upstream proteins signaling pathways have elucidated. Based existing problems, we suggested future studies paying attention patients’ samples animal models syndromes, conducting rescue experiments, exploring more regulators, adopting new technical methods. hope this review can provide a theoretical basis novel ideas clarifying mechanisms via
Language: Английский
Citations
15
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 22, 2025
Background Periplanta americana extract (PAE), a traditional Chinese medicine (TCM) from Shen Nong Ben Cao Jing , has been used to treat ulcerative colitis (UC), various types of wounds and ulcers, infantile malnutrition, palpitation, asthma, so on. However, the exact mechanisms PAE in UC have still not fully revealed. The study aims explore therapeutic effects UC. Methods efficacy was evaluated using DSS-induced mice model colon inflammation mucosal barrier were comprehensively assessed. Furthermore, Network pharmacological analysis utilized identify potential targets signaling pathways treatment. proportion markers Th17 Treg cells spleen examined. signal transduction detected vivo . In vitro an activated Notch1-mediated Th17/Treg modeled, effect on epithelial cell Results mitigated intestinal damage mice. showed that intervention by may be closely related differentiation, IL-17 pathway, cytokine-cytokine receptor interaction. Mechanistically, regulated balance inhibited Notch1/Math1 pathway alleviated imbalance Jurkat T cells. After notch1-activated co-cultured with HCoEpic cells, expressions Occludin, ZO1 higher Conclusion could alleviate UC, which are inhibition Notch1 regulation balance. might candidate agent for
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: March 17, 2025
Immune checkpoint inhibitor-induced colitis (irColitis) is a common and severe adverse reaction to immune inhibitors (ICIs), significantly impacting the treatment outcomes quality of life cancer patients. Epidemiological studies indicate that incidence irColitis associated with factors such as type ICIs, patient's gender, age, medical history. Although exact pathophysiology remains unclear, thought be related system activation dysregulation, gut microbiota imbalance, impaired epithelial barrier function. This review summarized epidemiology, clinical presentation, diagnostic criteria, pathogenesis irColitis. Additionally, standard novel therapeutic strategies irColitis, including corticosteroids, biologics, interventions, more importantly potential application Traditional Chinese Medicine (TCM). Future researches call for deeper mechanistic investigations, development biomarkers, reveal integration TCM therapies within individual immunotherapy frameworks.
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: April 9, 2025
Ulcerative colitis (UC), a chronic inflammatory bowel disease, is driven by dysregulated immune responses and persistent intestinal inflammation. Pyroptosis, caspase/gasdermin-mediated cell death that exacerbates mucosal damage through excessive cytokine release epithelial barrier disruption. Although pyroptosis considered to be key mechanism in the pathogenesis of UC, systematic assessment role natural products targeting pathway remains critical research gap. The purpose this review investigate regulatory effects on UC elucidate mechanisms action potential therapeutic effects. Key findings highlight polyphenols (e.g., resveratrol), flavonoids Quercetin), terpenoids as promising agents inhibit NLRP3 inflammasome activation, suppress gasdermin D cleavage, restore integrity, thereby reducing pro-inflammatory preclinical models. Current evidence shows enhanced efficacy safety when these compounds are combined with standard therapies, but clinical translation requires overcoming three barriers: limited human trial data, uncharacterized polypharmacology, suboptimal pharmacokinetics needing formulation refinement. Future should prioritize standardized animal-to-human translational models, mechanistic studies synergistic pathways, rigorous validation harness full pyroptosis-targeted therapies.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: April 10, 2024
Cancer ranks among the foremost causes of mortality worldwide, posing a significant threat to human lives. The advent tumor immunotherapy has substantially transformed therapeutic landscape for numerous advanced malignancies, notably non-small cell lung cancer and melanoma. However, as immune checkpoint inhibitors (ICIs) are increasingly applied in clinical settings, spectrum undesired reactions, termed immune-related adverse events (irAEs), emerged. These reactions associated with can result varying degrees harm body. Among these Immune inhibitor-induced colitis (ICIIC) stands out one most prevalent events. In contemporary times, traditional Chinese medicine (TCM) demonstrated remarkable efficacy addressing various maladies. Consequently, investigating potential application mechanisms countering assumes importance treatment this condition.
Language: Английский
Citations
2
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Sept. 17, 2024
Functional gastrointestinal disorders (FGIDs) and inflammatory bowel disease (IBD) are common clinical characterized by recurrent diarrhea abdominal pain. Although their pathogenesis has not been fully clarified, disruptions in intestinal motility immune function widely accepted as contributing factors to both conditions, the brain–gut axis plays a key role these processes. Traditional Chinese Medicine (TCM) employs holistic approach treatment, considers spleen stomach impairments liver abnormality main of two diseases, offers unique therapeutic strategy that targets interconnected pathways. Clinical evidence shows great potential TCM treating FGIDs IBD. This study presents systematic description pathological mechanisms IBD context axis, discusses preclinical studies on acupuncture for treatment summarizes pathways IBD, integrating ancient wisdom with contemporary biomedical insights. The alleviating effects FGID symptoms mainly mediated through modulation immunity inflammation, sensory transmission, neuroendocrine–immune network, microbiota metabolism mechanisms. may be promising option controlling IBD; however, further high-quality research is required. review provides reference an in-depth exploration interventional underscoring TCM’s recalibrate dysregulated
Language: Английский
Citations
2
Pharmacognosy Magazine, Journal Year: 2024, Volume and Issue: 20(2), P. 676 - 685
Published: Jan. 3, 2024
Objectives This study aimed to evaluate the therapeutic effects and mechanism of genistein on dextran sulfate sodium-induced mouse model ulcerative colitis (UC). Materials Methods A DSS-induced for UC was used in this study. Mice were then treated with or a combination G protein-coupled estrogen receptor (GPER) antagonist G15. Colon length, disease activity index (DAI), spleen (SI), histopathological alterations, integrity colonic barrier evaluated. The expression inflammatory cytokines antioxidant capacity detected. Populations T helper 17 cells (Th17) Regulatory (Treg) mesenteric lymph nodes (MLN) analyzed. transcription factor Th17 Treg tissues Results Genistein treatment significantly alleviated colitis, summarized as increased decreased DAI, SI, improved integrity. restrained pro-inflammatory oxidative enzyme release while promoting anti-inflammatory anti-oxidative release. Flow cytometry indicated that reduced population boosting populations. Furthermore, inhibited factors associated promoted tissue. Intriguingly, these observed abolished when mice GPER Conclusion suggests is potent protecting against injuries by rebalancing Th17/Treg may be vital target genistein-mediated immunomodulatory UC.
Language: Английский
Citations
1
World Journal of Clinical Cases, Journal Year: 2024, Volume and Issue: 12(17), P. 3105 - 3122
Published: June 4, 2024
BACKGROUND Malancao (MLC) is a traditional Chinese medicine with long history of utilization in treating ulcerative colitis (UC). Nevertheless, the precise molecular mechanisms underlying its efficacy remain elusive. This study leveraged ultra-high-performance liquid chromatography coupled exactive mass spectrometry (UHPLC-QE-MS), network pharmacology, docking (MD), and gene microarray analysis to discern bioactive constituents potential mechanism action MLC UC management. AIM To determine ingredients related for treatment using multiple databases obtain targets fishing. METHODS research employs UHPLC-QE-MS identification compounds present plant samples. Furthermore, integrates identified compound-related publicly available elucidate common drug disease targets. Additionally, R programming language utilized predict central pathways that may impact UC. Finally, MD are conducted AutoDock Vina software assess affinity components main confirm their therapeutic potential. RESULTS Firstly, through comprehensive data public database resources, we 146 drug-disease cross 11 components. The Gene Ontology Kyoto Encyclopedia Genes Genomes highlighted primarily involved oxidative stress management, lipid metabolism, atherosclerosis, other processes. They also affect AGE-RAGE apoptosis signaling pathways. Secondly, by analyzing differences diseases, key These core active substances, including such as quercetin luteolin. revealed stability compound-protein binding, particularly between JUN-Luteolin, JUN-Quercetin, HSP90AA1-Wogonin, HSP90AA1-Rhein. Therefore, this suggests help alleviate intestinal inflammation UC, restore abnormal accumulation, regulate expression levels proteins intestine. CONCLUSION has demonstrated notable management means compound target interaction pathway. amalgamation botanical metabolomics, natural products, MD, chip technology presents propitious methodology investigating herbal medicines discerning novel constituents.
Language: Английский
Citations
1