The Nexus Between Traditional Chinese Medicine and Immunoporosis: Implications in the Treatment and Management of Osteoporosis DOI
Xiaolei Ding, Jie Yang,

Yuchi Wei

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

ABSTRACT Osteoporosis (OP) is a globally prevalent bone disease characterized by reduced mass and heightened fracture risk, posing significant health economic challenge to aging societies worldwide. Osteoimmunology—an emerging field of study—investigates the intricate relationship between skeletal immune systems, providing insights into system's impact on progression. Recent research has demonstrated essential roles played various cells (T cells, B macrophages, dendritic mast granulocytes, innate lymphoid cells) in regulating metabolism, homeostasis, formation, remodeling through interactions with osteoclasts (OC) osteoblasts (OB). These findings underscore that osteoimmunology provides an theoretical framework for understanding pathogenesis disorders, including OP. Traditional Chinese medicine (TCM) its active ingredients have clinical value OP treatment. Unfortunately, despite their striking multieffect pathways pharmacological field, current not yet summarized them comprehensive detailed manner respect interventional diseases, especially Consequently, this review addresses recent studies mechanisms which communication molecules contribute development. Additionally, it explores potential therapeutic benefits TCM components treating from perspective osteoimmunology. The objective provide enhances immune‐related diseases facilitate development novel strategies.

Language: Английский

Gut microbiota contributes to the intestinal and extraintestinal immune homeostasis by balancing Th17/Treg cells DOI
Jing Wang,

Yaqin Hou,

Lijun Mu

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113570 - 113570

Published: Nov. 15, 2024

Language: Английский

Citations

5
The Role of Mesenchymal Stromal Cells in the Treatment of Rheumatoid Arthritis DOI Creative Commons

Estera Bakinowska,

Aleksandra Wiktoria Bratborska, Kajetan Kiełbowski

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(11), P. 915 - 915

Published: May 25, 2024

Rheumatoid arthritis (RA) is a chronic inflammatory joint disease characterised by the formation of hyperplastic pannus, as well cartilage and bone damage. The pathogenesis RA complex involves broad interactions between various cells present in inflamed synovium, including fibroblast-like synoviocytes (FLSs), macrophages, T cells, among others. Under conditions, these are activated, further enhancing responses angiogenesis promoting degradation. Novel treatment methods for greatly needed, mesenchymal stromal (MSCs) have been suggested promising new regenerative immunomodulatory treatment. In this paper, we MSCs RA-FLSs, macrophages summarise studies examining use preclinical clinical studies.

Language: Английский

Citations

4
The absolute number of circulating Treg cells is reduced in difficult-to-treat RA patients and is ameliorated by low-dose IL-2 DOI Creative Commons
Huanhuan Yan,

Xiaoyu Zi,

Huer Yan

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 6, 2025

Circulating regulatory T cells (Tregs) are closely related to immune tolerance and maintenance of homeostasis. Perhaps, there is a unique cell phenotype for difficult-to-treat rheumatoid arthritis (D2T RA). Low-dose interleukin-2 (IL-2) has been considered the treatment autoimmune diseases. This study focused on uniqueness D2T RA lymphocyte subsets feasibility low-dose IL-2 therapy. Participants included 1,042 patients who were divided into three groups according presence or absence their response in last 6 months-new group, treated group-and 339 healthy controls (HCs). A total 381 patients-107, 151, 123 each experimental groups-received [0.5 million international units (MIU) per day, subcutaneous injection from day 1 5]. The absolute numbers peripheral blood detected by flow cytometry (FCM) serum cytokine levels bead array (CBA). number T, CD4+ Treg group was lower than that HC, new, groups. Compared with HC new ratio Th17/Treg increased. treated, had higher HC. negatively correlated disease activity index. could be increased therapy without any side effects. lymphocytes reduced, especially cells, resulting shift balance effector cells/Treg toward which ameliorated obvious

Language: Английский

Citations

0
Restoring immune tolerance in pre-RA: immunometabolic dialogue between gut microbiota and regulatory T cells DOI Creative Commons
Anqi Gao,

Ruihe Wu,

Yanfei Mu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 20, 2025

Rheumatoid arthritis (RA) is a complex chronic autoimmune disease that remains incurable for most patients. With advances in our understanding of the disease’s natural history, concept pre-RA has emerged as window opportunity to intervene before irreversible joint damage occurs. Numerous studies have indicated key step driving autoimmunity early lies at an extra-articular site, which closely related regulatory T (Treg) cell-established immune tolerance gut microbiota. The intricate immunometabolic crosstalk between Treg cells and microbiota beginning be understood, with re-recognition metabolic sensors recent years. In future, deciphering their dialogue may help elucidate underlying mechanisms pre-RA. Identifying novel biological pathways stage will bring insights into restoring tolerance, thereby potentially curing or preventing onset RA.

Language: Английский

Citations

0
Propofol alleviates traumatic brain injury through regulating Th17/Treg balance by activation of the AMPK/SIRT1 pathway DOI
Dan Wang, Hongyu Sun,

Kerong Hai

et al.

Toxicology Mechanisms and Methods, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: April 2, 2025

Traumatic brain injury (TBI), a prevalent neurological disorder in clinical practice, is primarily induced by external trauma. Propofol has been reported to alleviate the symptoms associated with TBI. In this study, TBI model was established mice using controlled cortical impact (CCI) method. After treatment propofol and BML-275, neuronal damage assessed through modified Neurological Severity Score (mNSS), Hematoxylin Eosin (HE) staining, Nissl staining. To investigate role of AMPK/SIRT1 pathway propofol-regulated TBI, AMPKα-silenced vectors overexpressed SIRT1 were transfected. Western blot performed evaluate expression proteins involved pyroptosis markers. The regulatory Th17/Treg balance examined detecting key transcription factors RORγt FOXP3 immunofluorescent staining RT-qPCR. Enzyme-linked immunosorbent assay (ELISA) used measure IL-17 IL-10 concentrations. Results showed that significantly reduced model, an effect reversed BML-275. Moreover, mitigated downregulating Caspase-1 GSDMD-N post-TBI. inhibited Th17 differentiation while promoting Treg modulating RORγt/FOXP3 IL-17/IL-10 levels. Silencing AMPKα markedly diminished propofol's effects on differentiation, these being upon overexpression. suppressed regulation via activation pathway. These findings suggest exerts protective against following potentially modulation signaling

Language: Английский

Citations

0
Dendritic cells in multiple myeloma: from immune evasion to therapeutic potential DOI Creative Commons

Mark L. Jordan,

Johannes Morschl,

Stella E. Autenrieth

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 17, 2025

Multiple myeloma (MM) is a type of hematologic cancer characterized by the uncontrolled clonal expansion plasma cells in bone marrow (BM). This leads to significant dysfunction and suppression immune system affected patients. Myeloma employ sophisticated strategies manipulate non-immune cells, evading surveillance enhancing their survival. One key factor this evasion disruption dendritic cell (DC)-mediated mechanisms. Extensive evidence indicates that presence DC numbers are notably reduced, phenotype function altered, impairing ability present antigens activate robust T-cell responses effectively. Despite rapid advances MM treatment, with promising such as DC-based vaccines being already achieved, remains substantial hurdle, associated or contributing poor therapeutic outcomes, disease relapse, MM’s persistence an incurable disease. To address these challenges, it essential understand intricate mechanisms through which transform DCs into “accomplices,” undermining responses. review comprehensively summarizes current understanding role MM. Additionally, evaluates potential anti-MM immunotherapy, discussing persistent challenges highlighting emerging perspectives may lead breakthroughs for improved patient outcomes.

Language: Английский

Citations

0
Dioscin alleviates aplastic anemia through regulatory T cells promotion DOI Creative Commons
Liwei Fan, Runfeng Ni, Haijin Wang

et al.

Hematology, Journal Year: 2024, Volume and Issue: 29(1)

Published: March 11, 2024

Objectives: Aplastic anemia (AA) is one of the immune-mediated bone marrow failure disorders caused by multiple factors, including inability CD4 + CD25 regulatory T cells (Tregs) to negatively regulate cytotoxic lymphocytes (CTLs). Dioscin a natural steroid saponin that has similar structure hormones. The purpose this study look into effect on functions CD25+ Tregs in AA mouse model and explore its underlying mechanism.

Language: Английский

Citations

1
Farnesyl pyrophosphate synthase inhibitors with antiosteoporosis efficacy in ovariectomized rats: A mixed binding approach beyond bisphosphonates DOI

Naglaa F. El- Sayed,

Marwa El‐Hussieny, Shaimaa T. Mansour

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 276, P. 116679 - 116679

Published: July 14, 2024

Language: Английский

Citations

0
The balance between helper T 17 and regulatory T cells in osteoimmunology and relevant research progress on bone tissue engineering DOI Creative Commons
Shuyu Zhu, Jing Zhou, Zhigang Xie

et al.

Immunity Inflammation and Disease, Journal Year: 2024, Volume and Issue: 12(9)

Published: Sept. 1, 2024

Abstract Background Bone regeneration is a well‐regulated dynamic process, of which the prominent role immune system on bone homeostasis more and revealed by recent research. Before fully activation remodeling cells, needs to clean up microenvironment in facilitating repair initiation. Furthermore, this must be maintained properly various mechanisms over entire process. Objective This review aims summarize T‐helper 17/Regulatory T cell (Th17/Treg) balance discuss relevant progress tissue engineering. Results The response early stages crucial, especially impact Th17/Treg osteoclasts, mesenchymal stem cells (MSCs), osteoblasts activity. By virtue these knowledge advancements, innovative approaches engineering, such as nano‐structures, hydrogel, exosomes, are designed influence thereby augment regeneration. Conclusion Targeting promising strategy for developing new treatments enhance regeneration, thus offering potential breakthroughs injury clinics.

Language: Английский

Citations

0
The Nexus Between Traditional Chinese Medicine and Immunoporosis: Implications in the Treatment and Management of Osteoporosis DOI
Xiaolei Ding, Jie Yang,

Yuchi Wei

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

ABSTRACT Osteoporosis (OP) is a globally prevalent bone disease characterized by reduced mass and heightened fracture risk, posing significant health economic challenge to aging societies worldwide. Osteoimmunology—an emerging field of study—investigates the intricate relationship between skeletal immune systems, providing insights into system's impact on progression. Recent research has demonstrated essential roles played various cells (T cells, B macrophages, dendritic mast granulocytes, innate lymphoid cells) in regulating metabolism, homeostasis, formation, remodeling through interactions with osteoclasts (OC) osteoblasts (OB). These findings underscore that osteoimmunology provides an theoretical framework for understanding pathogenesis disorders, including OP. Traditional Chinese medicine (TCM) its active ingredients have clinical value OP treatment. Unfortunately, despite their striking multieffect pathways pharmacological field, current not yet summarized them comprehensive detailed manner respect interventional diseases, especially Consequently, this review addresses recent studies mechanisms which communication molecules contribute development. Additionally, it explores potential therapeutic benefits TCM components treating from perspective osteoimmunology. The objective provide enhances immune‐related diseases facilitate development novel strategies.

Language: Английский

Citations

0