Journal of Enzyme Inhibition and Medicinal Chemistry,
Journal Year:
2025,
Volume and Issue:
40(1)
Published: Feb. 6, 2025
Lespedeza
bicolour
Turcz.
is
a
traditional
medicinal
plant
with
wide
range
of
ethnomedicinal
values.
The
main
components
L.
essential
oil
(EO)
were
β-pinene
(15.41%),
β-phellandrene
(12.43%),
and
caryophyllene
(7.79%).
EO
showed
antioxidant
activity
against
ABTS
radical
DPPH
an
IC50
value
0.69
±
0.03
mg/mL
10.44
2.09
mg/mL,
respectively.
FRAP
was
81.96
6.17
μmol/g.
had
activities
acetylcholinesterase,
α-glucosidase,
β-lactamase
values
309.30
11.16
μg/mL,
360.47
35.67
27.54
1.21
Molecular
docking
methyl
dehydroabietate
docked
well
all
tested
enzymes.
Sclareol
(+)-borneol
acetate
the
strongest
binding
affinity
to
α-glucosidase
β-lactamase,
present
study
provides
direction
for
searching
enzyme
inhibitors
three
enzymes
shows
possesses
potential
treat
series
diseases.
Inflammopharmacology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 12, 2025
Abstract
Using
a
bioassay-guided
fractionation
approach,
the
most
potent
anti-psoriatic
components
of
Aster
squamatus
herb,
chinensis
stalks,
and
flowers,
cultivated
in
Egypt,
were
identified
evaluated
against
Imiquimod
(IMQ)-induced
psoriasis
female
BALB/c
mice
compared
to
standard
drug,
mometasone.
The
topical
application
A.
stalk
methanolic
extract
exhibited
strongest
effects
IMQ-induced
model,
as
evidenced
by
improvements
area
severity
index
(PASI)
score,
histopathological
analysis,
spleen
index.
Further
using
petroleum
ether,
methylene
chloride,
ethyl
acetate,
n
-butanol
revealed
that
chloride
fraction
(MCF)
was
potent.
Indeed,
MCF
significantly
reduced
PASI
alleviated
changes,
restored
Mechanistically,
exerted
its
suppressing
inflammation,
decreased
TLR-4
gene
expression
lower
levels
HMGB1
NFκBp65
protein
contents.
Additionally,
serum
pro-inflammatory
cytokines
interleukin
(IL)-1β,
IL-6,
IL-23,
IL-17
while
mitigating
oxidative
stress
through
increased
superoxide
dismutase
(SOD)
activity
malondialdehyde
(MDA)
content.
Notably,
efficacy
comparable
mometasone,
with
no
significant
differences
observed.
In
parallel,
chemical
profile
analyzed
UHPLC-MS/MS
techniques
negative
positive
ionization
full
scan
modes.
could
be
used
potential
therapeutic
agent
for
psoriasis.
Journal of Inflammation Research,
Journal Year:
2025,
Volume and Issue:
Volume 18, P. 4213 - 4231
Published: March 1, 2025
Plaque
psoriasis
is
an
inflammatory
skin
disorder
affecting
nearly
2%
of
the
world
population.
Despite
recent
advances
in
treatment,
there
still
a
need
for
more
effective
therapies.
The
ETS
transcription
factor
FLI1
plays
critical
roles
hematopoiesis,
angiogenesis,
immunity,
and
cancer.
Emerging
evidence
suggests
that
intricately
involved
processes
underlying
pathogenesis.
RNAseq
bioinformatic
analysis
were
used
to
identify
correlation
between
levels
expression
genes
associated
with
psoriasis.
Over-expression
cells
determined
FLI1's
role
inducing
psoriasis-related
genes,
including
IL6,
IL1A,
IL1B,
IL23,
TNFα.
Inhibitors
such
as
chelerythrine
(CLT)
tested
their
suppressive
effects
on
these
genes.
Mouse
models
plaque
employed
assess
therapeutic
potential
CLT
tacrolimus
(TAC).
upregulated
24
psoriasis-associated
which
identified
through
RNAseq.
FLI1,
CLT,
suppressed
cells.
In
mouse
induced
by
imiquimod
(IMQ)
or
phorbol
ester
(TPA),
treatment
anti-FLI1
inhibitor
administered
either
peritoneally
topically,
significantly
downregulated
alleviated
symptoms.
Similarly,
TAC,
common
immunosuppressive
agent,
effectively
attenuated
IMQ-induced
acting
potent
compound.
These
findings
demonstrate
central
development
highlight
it
target
this
disorder.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(12), P. 2869 - 2869
Published: June 16, 2024
Spermacoce
alata
Aubl.
is
widely
available
in
the
market
as
traditional
Chinese
medicine
and
animal
feed,
due
to
its
properties
of
clearing
heat
treating
malaria
high-protein
crude
fiber
content.
In
this
study,
essential
oil
S.
was
obtained
through
hydrodistillation.
GC–MS
GC–FID
methods
were
used
identify
chemical
components
their
relative
abundance.
Furthermore,
antioxidant
capacity
measured
using
DPPH,
ABTS,
FRAP
assays,
inhibitory
effects
acetylcholinesterase,
α-glucosidase,
β-lactamase
also
evaluated.
A
total
67
compounds
identified,
with
major
constituents
being
palmitic
acid
(30.74%),
linoleic
(16.13%),
phenylheptatriyne
(8.07%).
The
exhibited
moderate
activity
against
DPPH
(IC50
>
10
mg/mL),
while
IC50
value
for
ABTS
assay
3.84
±
2.12
mg/mL
87.22
12.22
µM/g.
Additionally,
showed
anti-acetylcholinesterase
=
286.0
79.04
μg/mL),
significant
anti-α-glucosidase
174.7
13.12
potent
anti-β-lactamase
37.56
3.48
μg/mL).
results
suggest
that
has
potential
application
pharmacology,
warranting
further
exploration
investigation.
Tropical Journal of Natural Product Research,
Journal Year:
2024,
Volume and Issue:
8(2)
Published: March 2, 2024
Globally,
several
medicinal
plants
have
been
reported
in
treating
Alzheimer’s
disease
(AD).
AD
is
characterised
by
decreased
acetylcholine-mediated
neurotransmission,
which
acetylcholinesterase
inhibitors
an
impact
as
neuron-protective.
The
aim
to
discover
a
new
therapeutic
agent
for
from
available
natural
sources
with
fewer
side
effects
than
other
synthetic
ones.
current
work
provides
evidence
of
the
preventive
and
properties
three
coniferous
plants,
Cupressus
arizonica
Greene
(CA),
lusitanica
Mill.
(CL)
Pinus
canariensis
C.Sm.
(PC).
This
was
achieved
screening
their
potential
inhibition
(AChE)
butyrylcholinesterase
(BChE).
Additionally,
antioxidant
activity
determined
through
different
assays;
Ferric-reducing
power,
radical
cation-based
2,2′-azino-bis
(3-ethylbenzothiazoline-6-sulfonic
acid)
oxygen
absorbance
capacity.
Phytochemical
performed
determination
total
polyphenolic
content
(TPC)
flavonoid
(TFC).
results
proved
that
best
AChE
possessed
CL
CA
(IC50:
199.7
±
15.3
263.7
17.3
µg/mL,
respectively).
showed
significantly
more
potent
on
BChE
74.3
2.1
µg/mL)
PC
(136.3
3.8,
˃500
respectively),
comparison
standard.
extracts
assays
(107-1143
µM
Trolox
eq/mg
sample).
had
highest
concentration
TFC,
while
TPC.
study
revealed
significant
vitro
potential,
inhibitory
CA.
In
conclusion,
extract
could
be
promising
source
bioactive
metabolites
neurological
diseases.
