Chemistry & Biodiversity,
Journal Year:
2023,
Volume and Issue:
20(10)
Published: Sept. 12, 2023
In
the
investigation
of
Meehania
fargesii,
eighteen
triterpenoids
were
isolated
and
identified,
including
a
previously
unknown
compound
with
an
13,27-cycloursane
skeleton,
using
techniques
like
1D
2D
NMR,
HR-MS.
Furthermore,
cytotoxicity
these
compounds
evaluated
against
HCT116,
MCF-7,
AGS
cell
lines
CCK-8
method
to
examine
their
structure-activity
relationship.
Remarkably,
13
16
exhibited
higher
across
all
three
compared
positive
drug.
Western
blot
analysis
revealed
that
activated
apoptosis
in
HCT116
cells
by
promoting
Bax
protein
inhibiting
Bcl-2
protein.
This
suggests
have
potential
as
apoptosis-inducing
agents
cells.
Current Issues in Molecular Biology,
Journal Year:
2024,
Volume and Issue:
46(4), P. 2884 - 2925
Published: March 26, 2024
At
present,
the
occurrence
of
a
large
number
infectious
and
non-communicable
diseases
poses
serious
threat
to
human
health
as
well
drug
development
for
treatment
these
diseases.
One
most
significant
challenges
is
finding
new
candidates
that
are
therapeutically
effective
have
few
or
no
side
effects.
In
this
respect,
active
compounds
in
medicinal
plants,
especially
flavonoids,
potentially
useful
with
wide
range
pharmacological
activities.
They
naturally
present
nature
valuable
many
Flavonoids
divided
into
fourteen
categories
mainly
derived
from
plant
extraction,
chemical
synthesis
structural
modification,
biosynthesis.
The
modification
flavonoids
an
important
way
discover
drugs,
but
biosynthesis
currently
considered
promising
research
direction
potential
revolutionize
production
pipeline
flavonoids.
However,
relevant
problems
such
metabolic
pathway
analyses
cell
protocols
need
be
addressed
on
urgent
basis.
review,
techniques
assessing
biological
activities
mechanisms
their
elucidated
modes
interaction
other
drugs
described.
Moreover,
novel
delivery
systems,
nanoparticles,
bioparticles,
colloidals,
etc.,
gradually
becoming
means
addressing
issues
poor
hydrophilicity,
lipophilicity,
stability,
low
bioavailability
review
summarizes
latest
progress
existing
therapeutic
efficacy,
how
can
solved
Journal of Translational Internal Medicine,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 24, 2025
Abstract
Eupatilin,
a
flavonoid
found
in
Artemisia
argyi
(Compositae)
leaves,
exhibits
robust
anti-inflammatory,
antioxidant,
and
anti-tumor
properties.
Numerous
investigations
have
demonstrated
remarkable
efficacy
of
eupatilin
across
various
disease
models,
spanning
digestive,
respiratory,
nervous,
dermatological
conditions.
This
review
aims
to
provide
an
overview
recent
studies
elucidating
the
mechanistic
actions
spectrum
models
evaluate
its
clinical
applicability.
The
findings
herein
valuable
insights
for
advancing
study
novel
Traditional
Chinese
Medicine
compounds
their
utilization.
Chemical and Biological Technologies in Agriculture,
Journal Year:
2025,
Volume and Issue:
12(1)
Published: Jan. 6, 2025
Abstract
Sparassis
latifolia
is
a
rare
edible
mushroom
with
many
pharmacological
activities.
Active
screening
found
that
the
crude
polysaccharide
from
this
(SLP)
exhibited
noticeable
gastroprotective
effects.
However,
it
remains
unclear
regarding
underlying
regulatory
mechanism
of
effects
SLP.
A
novel
SLP-2
was
purified
fruiting
bodies
S.
,
and
characterized
using
FT-IR,
HPAEC,
SEM,
SEC–MALLS-RI,
methylation,
NMR
analysis.
Structural
characterization
revealed
backbone
mainly
composed
→
4)-α-D-Glcp-(1
3)-α-D-Glcp-(1
3,4)-α-D-Glcp-(1
.
The
branched
chain
primarily
consisted
β-D-Glcp-(1
linked
to
sugar
residue
3,
6)-β-D-Glcp-(1
at
O-6
position
3,4)-β-D-Glcp-(1
O-4
position.
Physiological
experimental
results
demonstrated
effectively
protected
GES-1
cells
against
ethanol-induced
damage
by
suppressing
intracellular
ROS
levels
cell
apoptosis
while
elevating
activities
SOD
CAT
enzymes.
Furthermore,
transcriptome
analysis
molecular
mechanisms
effect
SLP-2,
KEGG
enrichment
suggesting
associations
ferroptosis,
TNF,
PI3K–Akt,
MAPK
IL-17
signaling
pathways.
These
findings
provide
technological
foundation
for
valuable
utilization
emphasize
potential
application
in
repairing
gastric
mucosal
injuries.
Graphical
Jundishapur Journal of Natural Pharmaceutical Products,
Journal Year:
2025,
Volume and Issue:
20(2)
Published: April 16, 2025
Context:
Humans
have
used
plants
for
their
medicinal
needs
since
ancient
times.
Artemisia
is
an
important
plant
genus
that
includes
about
500
different
species,
many
of
which
are
known
therapeutic
effects.
One
the
valuable
species
this
genus,
ciniformis,
exhibits
interesting
biological
effects,
yet
there
no
comprehensive
report
on
its
properties.
Evidence
Acquisition:
Data
were
collected
through
extensive
literature
searches
in
web
databases,
including
PubMed,
Scopus,
Web
Science,
Wiley
Online
Library,
SpringerLink,
Google
Scholar,
Science
Direct,
ResearchGate,
and
Plants
World
Online,
up
until
December
2024.
The
chemical
structures
retrieved
from
PubChem
database
drawn
using
ChemDraw
Professional
16.0
software.
Results:
This
paper
provides
information
distribution,
botanical
characteristics,
phytochemistry,
effects
may
be
useful
conducting
further
research
related
fields
such
as
pharmacognosy,
pharmacology,
natural
product
chemistry.
Conclusions:
a
with
prominent
cytotoxic,
antifungal,
cytoprotective,
antileishmanial
along
other
bioactivities,
can
new
source
discovering
promising
bioactive
molecules.
PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(11), P. e0313251 - e0313251
Published: Nov. 5, 2024
Background
Eupatilin,
a
flavone
isolated
from
Artemisia
species,
exerts
anti-inflammatory,
anti-oxidative,
and
anti-neoplastic
activities.
However,
the
effects
of
eupatilin
on
H
.
pylori
-associated
gastritis
remain
unclear.
Thus,
this
study
aimed
to
investigate
anti-inflammatory
gastric
epithelial
cells
infected
with
cytotoxin-associated
gene
A
(CagA)-positive
Helicobacter
Materials
methods
AGS
human
carcinoma
were
CagA-positive
strain
then
treated
10,
50,
or
100
ng
eupatilin.
After
24
h,
expression
levels
CagA,
phosphoinositide
3-kinase
1
(PI3K),
nuclear
factor
(NF)-κB,
interleukin
(IL)-1β,
tumor
necrosis
(TNF)-α
in
cell
lysates
measured
using
western
blotting,
mRNA
IL-6,
IL-8,
monocyte
chemoattractant
protein
(MCP)-1
real-time
polymerase
chain
reaction.
Results
CagA
translocation
into
resulted
an
elongated
morphology,
which
was
significantly
suppressed
by
treatment
dose-dependent
manner.
Immunofluorescence
staining
for
anti-CagA
showed
that
dose-dependently
inhibited
-infected
cells.
infection
increased
pro-inflammatory
cytokines
including
IL-1β,
TNF-α,
MCP-1,
reduced
these
Additionally,
PI3K
NF-κB.
Conclusions
Eupatilin
demonstrated
inhibiting
translocation,
thereby
suppressing
NF-κB
signaling
pathway.
These
results
suggest
plays
protective
role
against
-induced
gastritis.
