Dysbiosis of gut microbiota is associated with pathogenesis of peptic ulcer diseases through inflammatory proteins: A Mendelian randomization study DOI Creative Commons
Jianing Li, Hongbo Cai,

Yongsheng Zhang

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(39), P. e39814 - e39814

Published: Sept. 27, 2024

The gut microbiota and inflammatory proteins may affect the development of peptic ulcer disease. However, this association remains unclear. We analyzed genome-wide study data microbiota, proteins, disease using Mendelian randomization with instrumental variables to assess causal relationships. Various statistical methods, including inverse variance weighting, Egger regression, sensitivity analysis were employed evaluate calculate mediation ratios. Our findings reveal that genus Butyriciccus plays a role in mitigating adverse effects gastric ulcers by 7.9%, primarily through reducing beta-negative growth factor levels. Additionally, Lachnospiraceae UCG004 can significantly alleviate negative outcomes reduces hepatocyte beta-reserve levels 6.39% 7.45%, respectively. This highlights independent mediating on ulcers, offering insights potential pathways targets for future preventive interventions.

Language: Английский

Polysaccharides from an edible mushroom, Hericium erinaceus, alleviate ulcerative colitis in mice by inhibiting the NLRP3 inflammasomes and reestablish intestinal homeostasis DOI
Hao Li,

Jiaxin Feng,

Chang Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 267, P. 131251 - 131251

Published: March 30, 2024

Language: Английский

Citations

11
Microenvironment-responsive sodium alginate hydrogel loaded with MnO2 and pachymic acid for the treatment of gastric ulcer DOI Open Access
Xin Qian, Fan Zhou,

Jiawen Zheng

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 183, P. 117835 - 117835

Published: Jan. 20, 2025

Language: Английский

Citations

0
Sporidiobolus pararoseus polysaccharides relieve rheumatoid arthritis by regulating arachidonic acid metabolism and bone remodeling signaling pathway DOI
Hongkang Zhu,

Fanglin Shen,

Tingting Liao

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 136272 - 136272

Published: Oct. 1, 2024

Language: Английский

Citations

3
Dysbiosis of gut microbiota is associated with pathogenesis of peptic ulcer diseases through inflammatory proteins: A Mendelian randomization study DOI Creative Commons
Jianing Li, Hongbo Cai,

Yongsheng Zhang

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(39), P. e39814 - e39814

Published: Sept. 27, 2024

The gut microbiota and inflammatory proteins may affect the development of peptic ulcer disease. However, this association remains unclear. We analyzed genome-wide study data microbiota, proteins, disease using Mendelian randomization with instrumental variables to assess causal relationships. Various statistical methods, including inverse variance weighting, Egger regression, sensitivity analysis were employed evaluate calculate mediation ratios. Our findings reveal that genus Butyriciccus plays a role in mitigating adverse effects gastric ulcers by 7.9%, primarily through reducing beta-negative growth factor levels. Additionally, Lachnospiraceae UCG004 can significantly alleviate negative outcomes reduces hepatocyte beta-reserve levels 6.39% 7.45%, respectively. This highlights independent mediating on ulcers, offering insights potential pathways targets for future preventive interventions.

Language: Английский

Citations

2