Journal of Chromatography B, Journal Year: 2024, Volume and Issue: 1250, P. 124386 - 124386
Published: Nov. 17, 2024
Language: Английский
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: June 21, 2024
The drug development process is poised for significant transformation due to the rapid advancement of modern biological and information technologies, such as artificial intelligence (AI). As these new technologies concepts infiltrate every stage development, efficiency success rate research are expected improve substantially. Traditional Chinese medicine (TCM), a time-honored therapeutic system encompassing herbal medicine, acupuncture, qigong, will also be profoundly impacted by advancements. Over next decade, encounter both opportunities challenges it integrates with concepts. By 2035, TCM anticipated merge through more contemporary open model, providing substantial support treating broader spectrum diseases.
Language: Английский
Citations
8
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 7, 2025
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss. Glycogen synthase kinase 3β (GSK-3β) plays pivotal role in AD pathogenesis, particularly tau protein hyperphosphorylation. Natural bioactive compounds have wide range of sources, medicinally valuable active compound can be extracted from plants, animals, microorganisms. Currently, studies found that various natural plants the potential to improve symptoms, such as resveratrol berberine. Therefore, this review examines modulate GSK-3β activity inhibit hyperphosphorylation tau, offering promising therapeutic strategy for AD. We summarize current understanding alkaloids, phenols, flavonoids, terpenoids other compounds, highlighting their mechanisms action preclinical efficacy.
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: March 17, 2025
Alzheimer's disease (AD) is a common neurodegenerative disorder characterized by memory decline, cognitive impairment, and behavioral abnormalities. Pathologically, AD marked neurofibrillary tangles caused excessive phosphorylation of Tau protein abnormal deposition β-amyloid (Aβ) in the brain. The PI3K/AKT signaling pathway plays crucial role development, survival, metabolic regulation central nervous system, particularly neuronal growth, differentiation, apoptosis. However, this often inhibited patients.In recent years, studies have shown that herbal formulations extracts derived from Traditional Chinese Medicine (TCM) can regulate pathway, thereby improving pathological models. This study reviews fundamental research on both active metabolites compound TCM for treatment AD, targeting pathway.Keywords include "Alzheimer's disease" "AD" "dementia" "PI3K" "AKT" "Traditional Medicine" "Chinese herbology" medicine" "TCM".The based relevant literature published over past 15 primarily sourced electronic databases such as Web Science, PubMed, CNKI, Wanfang, VIP databases.The findings indicate mitigate pathology regulating reducing Aβ deposition, inhibiting inflammatory responses oxidative stress, alleviating enhances our understanding anti-AD mechanisms through offers new insights future.
Language: Английский
Citations
0
Pharmacological Research - Modern Chinese Medicine, Journal Year: 2024, Volume and Issue: 13, P. 100543 - 100543
Published: Nov. 6, 2024
Language: Английский
Citations
0
Journal of Chromatography B, Journal Year: 2024, Volume and Issue: 1250, P. 124386 - 124386
Published: Nov. 17, 2024
Language: Английский
Citations
0