Cited by Fermented licorice extract alleviates ulcerative colitis by inhibiting the TLR4/NF-κB pathway and rebuilding intestinal microbiota in mice

Anti-Inflammatory and Immunomodulatory Effects of Glycyrrhiza uralensis Fisch. on Ulcerative Colitis in Rats: Role of Nucleotide-binding oligomerization domain 2/Receptor-interacting protein 2/Nuclear factor-kappa B Signaling Pathway DOI

Rao Zhong,

Changlin Wen,

Yi Qiu

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119457 - 119457

Published: Feb. 1, 2025

Language: Английский

Citations

Mechanism of Action and Therapeutic Implications of Nrf2/HO-1 in Inflammatory Bowel Disease DOI

Lingling Yuan,

Yingyi Wang, Na Li

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 1012 - 1012

Published: Aug. 20, 2024

Oxidative stress (OS) is a key factor in the generation of various pathophysiological conditions. Nuclear erythroid 2 (NF-E2)-related (Nrf2) major transcriptional regulator antioxidant reactions. Heme oxygenase-1 (HO-1), gene regulated by Nrf2, one most critical cytoprotective molecules. In recent years, Nrf2/HO-1 has received widespread attention as regulatory pathway for intracellular defense against oxidative stress. It considered potential target treatment inflammatory bowel disease (IBD). This review highlights mechanism action and therapeutic significance IBD complications (intestinal fibrosis colorectal cancer (CRC)), well phytochemicals targeting IBD. The results suggest that effects on mainly involve following aspects: (1) Controlling to reduce intestinal inflammation injury; (2) Regulation flora repair mucosal barrier; (3) Prevention ferroptosis epithelial cells. However, due complex role Nrf2/HO-1, more nuanced understanding exact mechanisms involved way forward future.

Language: Английский

Citations

Betulinic acid mitigates lipopolysaccharide-induced intestinal injury of weaned piglets through modulation of the mitochondrial quality control DOI

Jiayu He,

Chunlin Huang, Li Kong

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 148, P. 114097 - 114097

Published: Jan. 18, 2025

Language: Английский

Citations

Therapeutic Effects of Natural Products in the Treatment of Chronic Diseases: The Role in Regulating KEAP1–NRF2 Pathway DOI

Yaling Li,

Xihua Wang,

Shuyue Li

et al.

The American Journal of Chinese Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 30

Published: Jan. 29, 2025

Oxidative stress represents a pivotal mechanism in the pathogenesis of numerous chronic diseases. The Kelch-like ECH-associated protein 1–transcription factor NF-E2 p45-related 2 (KEAP1–NRF2) pathway plays crucial role maintaining redox homeostasis and regulating multitude biological processes such as inflammation, homeostasis, metabolic homeostasis. In this paper, we present findings recent studies on KEAP1–NRF2 pathway, which have revealed that it is aberrantly regulated induces oxidative injury variety diseases neurodegenerative diseases, cardiovascular respiratory digestive cancer. Given evidence, targeting highly promising avenue for developing therapeutic strategies thus development appropriate based NRF2 has emerged significant area research interest. This paper highlights an overview current to modulate KEAP1–NRF2, well advances use natural compounds traditional Chinese medicine, with view providing meaningful guidelines drug discovery KEAP1–NRF2. Additionally, discusses challenges associated harnessing target.

Language: Английский

Citations

Pharmacological modulation of mitochondrial function as novel strategies for treating intestinal inflammatory diseases and colorectal cancer DOI

Boya Wang,

Xinrui Guo,

Lanhui Qin

et al.

Journal of Pharmaceutical Analysis, Journal Year: 2024, Volume and Issue: unknown, P. 101074 - 101074

Published: Aug. 1, 2024

Inflammatory bowel disease (IBD) is a chronic and recurrent intestinal disease, has become major global health issue. Individuals with IBD face an elevated risk of developing colorectal cancer (CRC), recent studies have indicated that mitochondrial dysfunction plays pivotal role in the pathogenesis both CRC. This review covers CRC, focusing on dysfunction, explores pharmacological targets strategies for addressing conditions by modulating function. Additionally, advancements modulation treating encompassing damage, release DNA (mtDNA), impairment mitophagy, are thoroughly summarized. The also provides systematic overview natural compounds (such as flavonoids, alkaloids, diterpenoids), Chinese medicines, microbiota, which can alleviate attenuate progression CRC In future, it will be imperative to develop more practical methodologies real-time monitoring accurate detection function, greatly aid scientists identifying effective agents through

Language: Английский

Citations

Effects of Licorice Functional Components Intakes on Blood Pressure: A Systematic Review with Meta-Analysis and NETWORK Toxicology DOI

Tianyu Wu, H. J. Yang,

Jiayue Xia

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(21), P. 3768 - 3768

Published: Nov. 2, 2024

Objective: To investigate the effects of licorice functional ingredient intake on blood pressure, explore its potential mechanisms action, and provide safety information for personalized nutritional interventions in special populations application licorice-derived foods. Methods: PubMed, Cochrane Library, Medline, Embase, EBSCO, ScienceDirect, Web Science databases were searched from inception to 31 August 2024. Randomized controlled trials (RCTs) investigating or components included. The range continuous variables was assessed using weighted mean difference (WMD) with 95% confidence intervals. Genes associated hypertension screened an online database. Machine learning, receiver operating characteristic(ROC) curve analysis, molecular docking, gene set enrichment analysis (GSEA) employed underlying licorice-induced pressure fluctuations. Results: Eight RCTs (541 participants) included meta-analysis, which indicated containing glycyrrhizic acid (GA) as main component increased systolic (SBP) diastolic (DBP) (SBP: WMD [95% CI] = 3.48 [2.74, 4.21], p < 0.001; DBP: 1.27 [0.76, 1.78], 0.001). However, dominated by flavonoids(LF) had no significant effect SBP DBP 0.58 [−1.15, 2.31], 0.511; 0.17 [−1.53, 1.88], 0.843). Three machine learning algorithms identified five biomarkers hypertension: calmodulin 3 (CALM3), cluster differentiation 9 (CD9), growth factor independence 1B transcriptional repressor (GFI1B), myosin light chain kinase (MYLK), Ras suppressor-1 (RSU1). After removing lower validity reliability, GFI1B, MYLK, RSU1 selected subsequent analysis. network toxicology results suggested that GA metabolite glycyrrhetinic may act RSU1, influencing fluctuations modulating nitrogen metabolism signaling pathways. Conclusions: There distinct differences pressure. Functional constituents shown increase both DBP, whereas those LF did not exhibit hypertensive mechanism involve modulation regulate metabolic

Language: Английский

Citations

An investigation into the HIF-dependent intestinal barrier protective mechanism of Qingchang Wenzhong decoction in ulcerative colitis management DOI

Meng-juan Yang,

Yi-nuo Zhang,

Zhi Qiao

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 325, P. 117807 - 117807

Published: Jan. 26, 2024

Language: Английский

Citations

Fermented licorice extract alleviates ulcerative colitis by inhibiting the TLR4/NF-κB pathway and rebuilding intestinal microbiota in mice DOI

Fuli Hu,

Jingyan Chen,

Yunxiang Xu

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 104918 - 104918

Published: Aug. 13, 2024

Language: Английский

Citations