Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: Jan. 28, 2025
Background
The
pathological
progression
from
liver
injury
to
fibrosis
is
a
hallmark
of
disease,
with
no
effective
strategies
halt
this
transition.
Ginsenoside
Rg1
has
demonstrated
range
hepatoprotective
properties;
however,
systematic
preclinical
evidence
supporting
its
therapeutic
potential
for
and
remains
limited.
Purpose.
This
study
evaluated
the
efficacy
underlying
mechanisms
ginsenoside
in
animal
models
fibrosis,
providing
basis
future
clinical
investigation.
Methods
A
review
was
conducted
on
studies
published
PubMed,
Web
Science,
Embase
databases
up
1
August
2024,
adhereing
rigorous
quality
standards.
methodological
assessed
using
SYRCLE’s
risk
bias
tool.
Meta-analysis
subgroup
analysis
were
performed
Revman
5.4
software,
while
publication
through
funnel
plots
Egger’s
test
STATA
15.0
software.
Additionally,
time-dose
interval
curve
utilized
assess
dose-response
relationship
identify
dose
treating
fibrosis.
Results
Twenty-four
trials
involving
423
animals
included.
findings
indicated
that
significantly
improved
function
markers
(ALT
AST),
reduced
indicators
associated
lowered
fibrosis-related
(α-SMA,
HYP,
PCIII).
Furthermore,
it
exhibited
beneficial
effects
mechanistic
inflammation,
oxidative
stress,
apoptosis,
compared
control
group
(
P
<
0.05).
Time-dose
revealed
between
4
800
mg/kg/d.
Conclusion
at
4–800
mg/kg/d
mitigates
via
anti-inflammatory,
antioxidative,
anti-apoptotic
pathways.
Systematic
Review
Registration
https://www.crd.york.ac.uk/PROSPERO/
,
identifier
CRD
42024557878.
Drug Metabolism Reviews,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 17
Published: July 30, 2024
The
growing
co-consumption
of
botanical
natural
products
with
conventional
medications
has
intensified
the
need
to
understand
potential
effects
on
drug
safety
and
efficacy.
This
review
delves
into
intricacies
intestinal
pharmacokinetic
interactions
between
drugs,
such
as
alterations
in
solubility,
permeability,
transporter
activity,
enzyme-mediated
metabolism.
It
emphasizes
importance
understanding
how
dissolution,
osmolality
interplay
constituents
gastrointestinal
tract,
potentially
altering
absorption
systemic
exposure.
Unlike
reviews
that
focus
primarily
enzyme
mechanisms,
this
article
highlights
lesser
known
but
equally
important
mechanisms
interaction.
Applying
Biopharmaceutics
Drug
Disposition
Classification
System
(BDDCS)
can
serve
a
framework
for
predicting
these
interactions.
Through
comprehensive
examination
specific
byakkokaninjinto,
green
tea
catechins,
goldenseal,
spinach
extract,
quercetin,
we
illustrate
diversity
their
dependence
physicochemical
properties
involved.
is
vital
healthcare
professionals
effectively
anticipate
manage
product-drug
interactions,
ensuring
optimal
patient
therapeutic
outcomes.
By
exploring
emerging
aim
broaden
scope
interaction
research
encourage
studies
better
elucidate
complex
mechanisms.
Journal of Functional Foods,
Journal Year:
2024,
Volume and Issue:
116, P. 106204 - 106204
Published: April 26, 2024
Chronic
kidney
disease
(CKD)
is
a
growing
global
public
health
issue.
Ginsenoside
Rg1
(Rg1)
has
favorable
nephroprotective
effects,
but
its
role
and
mechanism
in
CKD
need
further
investigation.
Therefore,
we
observed
the
effect
of
on
mouse
kidneys
after
21
days
low-dose
lipopolysaccharide
(LPS)
exposure.
Meanwhile,
investigated
protective
LPS-induced
mesangial
cells
using
Nrf2
inhibitor
ML385.
We
found
that
chronic
exposure
to
LPS
caused
fibrosis
kidneys,
accompanied
by
AIM2
activation
oxidative
stress
imbalance;
however,
restored
anomalies,
Nrf2/HO-1
signaling.
Finally,
our
vitro
studies
revealed
Rg1′s
effects
could
be
inhibited
ML385,
can
bind
Nrf2,
suggesting
may
involve
then
inhibition
AIM2.
Our
study
significant
implications
for
prevention
treatment
diseases,
particularly
those
related
inflammation.
IntechOpen eBooks,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 21, 2024
Metabolic
syndrome
includes
several
diseases
that
are
associated
with
metabolic
abnormalities
such
as
obesity,
dyslipidemia,
hypertension,
type
2
diabetes,
cardiac
diseases,
and
insulin
resistance.
In
order
to
maintain
cellular
homeostasis,
it
is
necessary
regulate
the
signaling
pathways
involved
in
controlling
oxidative
stress.
Nuclear
factor
erythroid-2
(NRF2)
a
transcription
largely
expressed
tissues
cells
participates
stress
regulation
pathways.
NRF2
also
mediates
transcriptional
of
variety
target
genes
signalize
acute
chronic
syndrome.
Deregulation
could
contribute
worst
prognosis/profile
individuals
Therefore,
its
activators
might
play
role
treatment,
highlighted
targets
for
modulation
by
pharmacological
agents.
PubMed,
Journal Year:
2024,
Volume and Issue:
57, P. e13885 - e13885
Published: Jan. 1, 2024
NLRP1,
the
first
identified
inflammasome-forming
sensor,
is
thought
to
be
involved
in
cancer,
yet
its
definite
function
lung
adenocarcinoma
(LUAD)
remains
unclear.
Herein,
we
explored
expression
and
of
NLRP1
LUAD.
Decreased
was
LUAD,
which
associated
with
a
poor
prognosis.
Overexpression
inhibited
tumor
growth
vitro
vivo.
Mechanically,
this
effect
observed
regardless
inflammasome
activation.
Further
studies
revealed
that
overexpression
downregulated
phosphorylation
DRP1
promoted
mitochondrial
fusion,
mediated
by
inhibition
NF-κB
activity.
agonist
could
neutralize
on
dynamics.
In
addition,
LUAD
sensitivity
cisplatin
enhanced
decreased
fission
resulting
from
up-regulated
NLRP1.
conclusion,
our
findings
demonstrated
an
unexpected
role
modulating
activities,
provides
strong
evidence
for
potential
treatment.
