Analysis of Major Chemical Constituents in Jiuwei Decoction Based On Capillary Electrophoresis Coupled With Quadrupole Time‐of‐Flight Mass Spectrometry DOI Open Access
Jiayu Zhao, Jinhong Li,

Hongyu Xue

et al.

Electrophoresis, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 24, 2024

An analytical method for identifying the chemical constituents in Chinese herbal combination Jiuwei decoction was established using capillary electrophoresis coupled with quadrupole time-of-flight mass spectrometry. Nine herbs were extracted a 60:40 (v/v) ethanol/water solution to prepare decoction. Electrophoretic separation carried out 50 µm i.d., 125 cm bare fused silica at constant temperature of 25°C sample injection. The composition analyzed and identified both positive negative ion modes. In mode, voltage 30 kV applied, 1% aqueous formic acid serving as background electrolyte (BGE), along 50:50 methanol/water containing 0.1% sheath liquid. -30 employed, utilizing mM ammonium acetate (pH 9.0) BGE, combined 5 MassHunter Qualitative Analysis software (version 10.0) utilized identify 52 compounds based on accurate mass, isotope abundance, isotopic patterns, fragmentation information. data compared Agilent Personal Compound Database Library traditional medicine (TCM), well multiple online databases (TCMSP, ChemSpider, PubChem, PubMed, Web Science) relevant literature. pathways representative also characterized. This study decoction, providing molecular basis further exploration its pharmacological effects presenting robust methodology compositional analysis complex TCM mixtures.

Language: Английский

Recent advances in the extraction, purification and analytical techniques for flavonoids from plants: Taking hawthorn as an example DOI
Zhe Han, Chunfeng Li, Guiyan Liu

et al.

Journal of Food Composition and Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 107372 - 107372

Published: Feb. 1, 2025

Language: Английский

Citations

0
The Multifaceted Anti-Atherosclerotic Properties of Herbal Flavonoids: A Comprehensive Review DOI Creative Commons

Mei‐Wen Huang,

Xuena Xie, Rong Yuan

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 211, P. 107551 - 107551

Published: Dec. 18, 2024

Language: Английский

Citations

2
The Role of Alarmins in the Pathogenesis of Atherosclerosis and Myocardial Infarction DOI Creative Commons
Kajetan Kiełbowski, Patryk Skórka,

Paulina Plewa

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(8), P. 8995 - 9015

Published: Aug. 17, 2024

Atherosclerosis is a condition that associated with lipid accumulation in the arterial intima. Consequently, enlarging lesion, which also known as an atherosclerotic plaque, may close blood vessel lumen, thus leading to organ ischaemia. Furthermore, plaque rupture and initiate formation of thrombus, can cause acute background pathological eventually lead major cardiovascular diseases such coronary syndrome or ischaemic stroke. The disorder altered profile alarmins, stress response molecules are secreted due cell injury death induce inflammatory responses. High-mobility group box 1 (HMGB1), S100 proteins, interleukin-33, heat shock proteins (HSPs) affect behaviour endothelial cells vascular smooth muscle (VSMCs). Thus, alarmins control responses proliferation VSMCs, two important processes implicated pathogenesis atherosclerosis. In this review, we will discuss role pathophysiology atherosclerosis myocardial infarction.

Language: Английский

Citations

1
A Comprehensive Review on the Isolation, Bioactivities, and Structure–Activity Relationship of Hawthorn Pectin and Its Derived Oligosaccharides DOI Creative Commons
Tao Li, Wenhua Ji, Hongjing Dong

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(17), P. 2750 - 2750

Published: Aug. 29, 2024

Hawthorn (

Language: Английский

Citations

1
LOX-1 as a biological marker and therapeutic target in cardiovascular pathology (literature review) DOI Creative Commons
Amina M. Alieva, Irina E. Baykova, Е. В. Резник

et al.

Consilium Medicum, Journal Year: 2024, Volume and Issue: 26(10), P. 666 - 673

Published: Nov. 23, 2024

Cardiovascular diseases (CVD) are a global medical, social and economic problem. Currently, the search study of new biological markers that can provide early diagnosis CVD, serve as laboratory tool for evaluating effectiveness treatment or be used prognostic criteria risk stratification continues. The interest scientists is focused on type 1 lectin-like receptor oxidized low-density lipoproteins (LOX-1) diagnostic marker in CVD. presented literature review highlights potential significance LOX-1 It expected future clinical experimental studies will confirm possibility using an additional non-invasive prognosis assessment patients with Modulation levels expression pharmacological drugs may prove to promising direction

Language: Английский

Citations

0
Analysis of Major Chemical Constituents in Jiuwei Decoction Based On Capillary Electrophoresis Coupled With Quadrupole Time‐of‐Flight Mass Spectrometry DOI Open Access
Jiayu Zhao, Jinhong Li,

Hongyu Xue

et al.

Electrophoresis, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 24, 2024

An analytical method for identifying the chemical constituents in Chinese herbal combination Jiuwei decoction was established using capillary electrophoresis coupled with quadrupole time-of-flight mass spectrometry. Nine herbs were extracted a 60:40 (v/v) ethanol/water solution to prepare decoction. Electrophoretic separation carried out 50 µm i.d., 125 cm bare fused silica at constant temperature of 25°C sample injection. The composition analyzed and identified both positive negative ion modes. In mode, voltage 30 kV applied, 1% aqueous formic acid serving as background electrolyte (BGE), along 50:50 methanol/water containing 0.1% sheath liquid. -30 employed, utilizing mM ammonium acetate (pH 9.0) BGE, combined 5 MassHunter Qualitative Analysis software (version 10.0) utilized identify 52 compounds based on accurate mass, isotope abundance, isotopic patterns, fragmentation information. data compared Agilent Personal Compound Database Library traditional medicine (TCM), well multiple online databases (TCMSP, ChemSpider, PubChem, PubMed, Web Science) relevant literature. pathways representative also characterized. This study decoction, providing molecular basis further exploration its pharmacological effects presenting robust methodology compositional analysis complex TCM mixtures.

Language: Английский

Citations

0