Emerging insights into ferroptosis in cholangiocarcinoma (Review) DOI Open Access
Xiaoyue Zhao, Miao Zhang, Jing He

et al.

Oncology Letters, Journal Year: 2024, Volume and Issue: 28(6)

Published: Oct. 14, 2024

Cholangiocarcinoma (CCA) is a malignant tumor that arises within the biliary system, which exhibits progressively increasing incidence and poor patient prognosis. A thorough understanding of molecular pathogenesis drives progression CCA essential for development effective target therapeutic approaches. Ferroptosis driven by excessive iron accumulation catalysis, lipid peroxidation failure antioxidant defense systems. Key targets metabolism, metabolism systems involve molecules such as transferrin receptor, ACSL4 GPX4, respectively. Inhibitors ferroptosis include ferrostatin-1, liproxstatin-1, vitamin E coenzyme Q10. By contrast, compounds erastin, RSL3 FIN56 have been identified inducers ferroptosis. serves notable role in onset CCA. cells exhibit high sensitivity to aberrant these increases oxidative stress accumulation. The induction markedly reduces ability proliferate migrate. Certain agonists, cause peroxide build up GPX4 inhibition induce cells. Current serological markers, CA-199, low specificity difficulties diagnosis However, novel techniques, non-invasive liquid biopsy assays markers double-cortin-like kinase 1, could improve diagnostic accuracy. primarily treated with surgery chemotherapy. close association between mechanisms related regulatory pathways has demonstrated. Therefore, it be suggested multi-targeted approaches, inducers, chelating agents modulators YL-939, may treatment efficacy. Iron death-related genes, are highly expressed associated prognosis patients represent potential prognostic present review focused on p53 ACSL4, process targeted medications combination PDT peroxidation, Xc

Language: Английский

Nrf2-mediated ferroptosis inhibition: a novel approach for managing inflammatory diseases DOI
Hang Han, Guojiang Zhang, Xiao Zhang

et al.

Inflammopharmacology, Journal Year: 2024, Volume and Issue: 32(5), P. 2961 - 2986

Published: Aug. 10, 2024

Language: Английский

Citations

13
Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence DOI Open Access

Yandra Cervelim Nunes,

Nathalia. M. Mendes,

Enzo Pereira de Lima

et al.

Published: July 12, 2024

Aging-related disorders pose significant challenges due to their complex interplay of physiological and metabolic factors, including inflammation, oxidative stress, mitochondrial dysfunction. Curcumin, a natural compound with potent antioxidant anti-inflammatory properties, has emerged as promising candidate for mitigating these age-related processes. However, gaps in understanding the precise mechanisms curcumin's effects optimal dosages different conditions necessitate further investigation. This systematic review synthesizes current evidence on potential addressing disorders, emphasizing its impact cognitive function, neurodegeneration, muscle health older adults. By evaluating safety, efficacy, action curcumin supplementation, this aims provide insights into therapeutic promoting healthy aging. A search across three databases using specific keywords yielded 2,256 documents, leading selection 15 clinical trials synthesis. Here we highlight multifaceted agent combating disorders. The findings suggest that could offer effective approach enhancing quality life aging individuals. Further research well-designed are essential validate optimize use personalized medicine approaches conditions.

Language: Английский

Citations

8
Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence DOI Open Access

Yandra Cervelim Nunes,

Nathalia. M. Mendes,

Enzo Pereira de Lima

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(16), P. 2721 - 2721

Published: Aug. 15, 2024

Aging-related disorders pose significant challenges due to their complex interplay of physiological and metabolic factors, including inflammation, oxidative stress, mitochondrial dysfunction. Curcumin, a natural compound with potent antioxidant anti-inflammatory properties, has emerged as promising candidate for mitigating these age-related processes. However, gaps in understanding the precise mechanisms curcumin’s effects optimal dosages different conditions necessitate further investigation. This systematic review synthesizes current evidence on potential addressing disorders, emphasizing its impact cognitive function, neurodegeneration, muscle health older adults. By evaluating safety, efficacy, action curcumin supplementation, this aims provide insights into therapeutic promoting healthy aging. A search across three databases using specific keywords yielded 2256 documents, leading selection 15 clinical trials synthesis. Here, we highlight multifaceted agent combating disorders. The findings suggest that could offer effective approach enhancing quality life aging individuals. Further research well-designed are essential validate optimize use personalized medicine approaches conditions.

Language: Английский

Citations

8
Stigmasterol from Prunella vulgaris L. Alleviates LPS-Induced Mammary Gland Injury by Inhibiting Inflammation and Ferroptosis DOI
Mingyang Sun, Dianwen Xu, Dianfeng Liu

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 137, P. 156362 - 156362

Published: Jan. 5, 2025

Language: Английский

Citations

1
Mitochondrial DNA leakage: underlying mechanisms and therapeutic implications in neurological disorders DOI Creative Commons
Guangming Zhang,

Huayuan Wei,

Anliu Zhao

et al.

Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)

Published: Feb. 7, 2025

Mitochondrial dysfunction is a pivotal instigator of neuroinflammation, with mitochondrial DNA (mtDNA) leakage as critical intermediary. This review delineates the intricate pathways leading to mtDNA release, which include membrane permeabilization, vesicular trafficking, disruption homeostatic regulation, and abnormalities in dynamics. The escaped activates cytosolic sensors, especially cyclic gmp-amp synthase (cGAS) signalling inflammasome, initiating neuroinflammatory cascades via pathways, exacerbating spectrum neurological pathologies. therapeutic promise targeting discussed detail, underscoring necessity for multifaceted strategy that encompasses preservation homeostasis, prevention leakage, reestablishment dynamics, inhibition activation sensors. Advancing our understanding complex interplay between neuroinflammation imperative developing precision interventions disorders.

Language: Английский

Citations

1
Ginsenosides for depression treatment: From benchside to bedside DOI Creative Commons

Jiayu Xie,

Feiya Zhu,

Yang Zhao

et al.

Journal of Traditional Chinese Medical Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Mitophagy and Ferroptosis in Sepsis-Induced ALI/ARDS: Molecular Mechanisms, Interactions and Therapeutic Prospects of Medicinal Plants DOI Creative Commons
Huixin Cheng, Xuehan Wang,

Juyi Yao

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 7819 - 7835

Published: Oct. 1, 2024

Sepsis is a common critical illness characterized by high mortality rates and significant disease burden. In the context of sepsis-induced organ dysfunction, lungs are among initial organs affected, which may progress to acute lung injury (ALI) respiratory distress syndrome (ARDS). Recent studies have highlighted crucial roles mitophagy ferroptosis in development progression ALI/ARDS. Identifying key convergence points these processes provide valuable insights for treatment this condition. recent years, certain herbs their bioactive compounds demonstrated unique benefits managing ALI/ARDS modulating or ferroptosis. This review summary mechanisms ferroptosis, explores interactions, emphasizes regulatory Additionally, it offers novel perspective on strategies summarizing various relevant

Language: Английский

Citations

4
In-Depth Investigation on Potential Mechanism of Forest-Grown Ginseng Alleviating Alzheimer’s Disease via UHPLC-MS-Based Metabolomics DOI Creative Commons

Huazhou Niu,

Meng Zhang, Kaiyue Zhang

et al.

Metabolites, Journal Year: 2025, Volume and Issue: 15(2), P. 93 - 93

Published: Feb. 3, 2025

Background: Alzheimer’s disease is a central nervous system degenerative closely related to age with complex pathogenesis. As natural medicinal plant, forest-grown ginseng (GSF) contains abundant ginsenosides and offers significant neuroprotective effects. Methods: In this study, we comprehensively investigated the effect of GSF on cell viability PC12 cells in an AD model alongside metabolic changes serum brains mice, combined efficacy evaluation vitro UHPLC-MS-based metabolomics vivo. The goal study clarify potential mechanism treating AD. Results: results showed that can promote proliferation cells, reduce content IL-8, increase activity SOD, alleviate inflammation oxidative stress induced by Aβ25~35. immunohistochemical for mouse brain tissue also could inflammatory response reducing overexpression IBa1. was alleviated Aβ protein deposition tissue. An untargeted analysis performed using UHPLC-Q-Exactive MS principal component (PCA) identify differentially expressed metabolites mice after treatment. Twenty seventeen different were identified tissue, respectively. pathway enrichment differential treat up-regulating succinic acid semialdehyde, carbamoyl phosphate, Sphingosine 1-phosphate, L-cystathionine, 2-ketobutyric acid, Vanillylmandelic D-Ribose regulate sphingomyelin metabolism, synthesis metabolism neurotransmitters precursors, energy metabolism. Conclusions: neuroinflammation regulating disorders amino acids, sphingolipids, unsaturated fatty arachidonic metabolites. These suggest link between metabolite imbalance AD, reveal basis

Language: Английский

Citations

0
Emodin protects against severe acute pancreatitis-associated acute lung injury by activating Nrf2/HO-1/GPX4 signal and inhibiting ferroptosis in vivo and in vitro DOI Creative Commons
Gang Shen, Haiyun Wen, Huijuan Li

et al.

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 5, 2025

Severe acute pancreatitis (SAP) has high morbidity, a complicated and dangerous course, many complications, including severe pulmonary complications. SAP-associated lung injury (SAP-ALI) is still significant challenge for surgeons because of its mortality. Therefore, more effective treatment methods are urgently needed. Emodin (EMO) shown tremendous potential in treating refractory diseases. However, protection mechanism SAP-ALI needs to be further clarified. This study was undertaken investigate the protective effects EMO against SAP rats alveolar epithelial cells, with particular focus on classical ferroptosis pathway. In an vivo study, forty SD were evenly split into five groups: sham operation (SO) group, biliopancreatic duct retrogradely injected 5% sodium taurocholate (STC) create + group administered via gavage following modeling, ML385 (a given inhibitor nuclear factor erythroid 2-related 2 (Nrf2)), group. vitro A549 cell lines exposed lipopolysaccharide (LPS) treated EMO. also used inhibit expression Nrf2. Pancreatic tissue damage evaluated using histological examination molecular experiments. Enzyme-linked immunosorbent assays (ELISA) assess levels pro-inflammatory cytokines, Fe2+, associated oxidative stress indicators serum supernatant. Real-time polymerase chain reaction (PCR), Western blot (WB), immunofluorescence find expressions related mRNAs proteins or cells. The findings demonstrated that suppressing Nrf2 exacerbated inflammatory response brought by pathological alterations SAP-ALI. reversed this change activating Nrf2/Heme Oxygenase-1 (HO-1)/glutathione peroxidase 4 (GPX4) signal path. Moreover, these results showed EMO, contrary ML385, suppressed response, which manifested as up-regulated glutathione (GSH) GPX4 down-regulated malondialdehyde (MDA), superoxide dismutase (SOD), reactive oxygen species (ROS) levels. Our effectively inhibited both vitro, while modulating Nrf2/HO-1/GPX4 signaling pathway provide

Language: Английский

Citations

0
Key Targets of Brain-Gut Coordination in Wuzhuyu Decoction Treating Chronic Migraine Based on Proteomics DOI
Meijing Li,

Zhimin Song,

Kristine Wang

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0