Pharmacokinetic and tissue distribution analysis of sporoderm-removed Ganoderma lucidum spore powder in rats

Journal of Chromatography B, Journal Year: 2025, Volume and Issue: 1259, P. 124626 - 124626

Published: April 26, 2025

Language: Английский

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Excretion characteristics of main compounds of Yigong San in urine, feces, and bile of rats

Biomedical Chromatography, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 3, 2024

Abstract Yigong San (YGS) is a traditional Chinese medicine formula used for pediatric anorexia, chronic atrophic gastritis, and irritable bowel syndrome. In this study, the excretion of eight main compounds, including liquiritin; isoliquiritin; hesperidin; ginsenosides Rb 1 , Re, Rg ; atractylenolides I II, in rat urine, feces, bile, was investigated by ultra‐high performance liquid chromatography–tandem mass spectrometry. The results showed that cumulative rates compounds bile were 0.018–1.15%, 0.024–19.89%, 0.0025–0.72%, respectively. Among detected, liquiritin richest Re atractylenolide mainly found feces bile. summary, components YGS are excreted via multiple approaches. Liquiritin through whereas II feces. these usually positively correlated with This study lays foundation further pharmacological research application YGS.

Language: Английский

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Comparisons of the bioavailability of icariin, icariside II, and epimedin C in rats after oral administration of total flavonoids of Epimedium brevicornu Maxim. and its three formulations

Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2024, Volume and Issue: 255, P. 116631 - 116631

Published: Dec. 10, 2024

Language: Английский

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The dynamic distribution patterns and lung targeting efficiency in rats of 9 bioactive components in Siraitia grosvenorii

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 119233 - 119233

Published: Dec. 1, 2024

Language: Английский

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