The Impact of Oxidized Regenerated Cellulose Application during Cystectomy and Drainage in Endometrioma Patients: A Retrospective Cohort Study DOI Creative Commons

Luky S Marwali,

Marcel Ezra Setiawan,

Malvin Emeraldi

et al.

Gynecology and Minimally Invasive Therapy, Journal Year: 2024, Volume and Issue: 14(1), P. 51 - 56

Published: Dec. 30, 2024

Abstract Objectives: This study aims to determine the impact of oxidized regenerated cellulose (ORC) during cystectomy and drainage on recurrence ovarian reserve. Materials Methods: Women aged 18–45 years with endometrioma (pathologically confirmed) who underwent conservative laparoscopy surgery (cystectomy drainage) using ORC at Fatmawati General Hospital Jakarta, Indonesia, were included in this study. All surgeries done by complete excision all endometriosis lesions (especially for deep infiltrating adenomyosis resection). patients followed up 1 year, rate postoperative anti-Mullerian Hormone (AMH) evaluated. Results: Twenty group 19 group. The researchers found result was not significant ( P = 0.622) rate. AMH decreased from 3.0 ± 1.8 2.1 1.5 Conversely, 1.4 1.25 1.1 0.9 reduction level more 0.002) than 0.124). Conclusion: Cystectomy significantly reduces Drainage insertion cyst cavity can be an option maintain reserve a risk that is different cystectomy.

Language: Английский

Endometriosis Update DOI

Denise G. Link

The Journal for Nurse Practitioners, Journal Year: 2025, Volume and Issue: 21(3), P. 105317 - 105317

Published: Jan. 30, 2025

Citations

0
Human Leukocyte Antigen Haplotypes Predisposing to Celiac Disease in Patients With Endometriosis DOI Creative Commons
Silvia Vannuccini,

Virginia Manzi,

Mirko Tarocchi

et al.

American Journal of Reproductive Immunology, Journal Year: 2025, Volume and Issue: 93(4)

Published: April 1, 2025

ABSTRACT Problem Immunological abnormalities are well recognized in the pathogenesis of endometriosis and co‐existence with inflammatory bowel disease (IBD) celiac (CD), along other systemic immune disorders, is clinically relevant. Recent genetic studies revealed some shared traits associated co‐occurrence different gastrointestinal or autoimmune highlighting common biological pathways. Since class II human leukocyte antigen (HLA) genes, HLA‐DQ2 ‐DQ8, show strongest best‐characterized susceptibility for CD, present study aims to explore presence these haplotypes non‐celiac patients endometriosis. Method Study A group ( n = 126) participated were compared healthy women 379), as controls. Subjects who diagnosed CD tested positive antibodies excluded. All controls genotyped HLA predisposing (DQ2, DQ8). In DQ2 and/or DQ8, symptoms also investigated. Results At least one ‐DQ8 genotypes was detected 43.3% (OR: 1.82, 95% CI: 1.11–2.81), whereas 29.5% p < 0.01) presented CD. patients, no significant difference shown between negative terms phenotype, gynecological, non‐gynecological symptoms. Conclusions Our data a significantly greater prevalence endometriosisthan subjects, suggesting that background may explain

Language: Английский

Citations

0
Endometriosis: Challenges in Clinical Molecular Diagnostics and Treatment DOI Open Access
Pedro Rosendo‐Chalma, Erick Nicolás Díaz-Landy, Verónica Antonio-Véjar

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 3979 - 3979

Published: April 23, 2025

Endometriosis is a chronic disease affecting approximately 10% (190 million) of women and girls reproductive age worldwide. It associated with variety often debilitating symptoms, including severe pelvic pain, pain during intercourse, bowel movements and/or urination, bloating, nausea, fatigue, risk infertility, as well depression anxiety in some cases. This review summarized the pathogenesis endometriosis criteria for clinical diagnosis, proposed panel potential biomarkers predictive molecular choice treatments infertility management.

Language: Английский

Citations

0
The connection between endometriosis and secondary dysmenorrhea DOI

Ismat Ara Begum

Journal of Reproductive Immunology, Journal Year: 2025, Volume and Issue: 168, P. 104425 - 104425

Published: Jan. 9, 2025

Language: Английский

Citations

0
Reduced live birth rates following ART in adenomyosis patients: a matched control study DOI
Mathilde Bourdon, Ahmed Mimouni,

Chloé Maignien

et al.

Human Reproduction, Journal Year: 2025, Volume and Issue: unknown

Published: March 30, 2025

Abstract STUDY QUESTION How does adenomyosis affect live birth rates (LBRs) in women undergoing ART compared to a matched control population? SUMMARY ANSWER Women with adenomyosis, controls for age, blastocyst count, and top-quality exhibited reduced LBR following IVF/ICSI treatment. WHAT IS KNOWN ALREADY Adenomyosis, benign uterine disorder, is believed hinder implantation due anatomical, hormonal, immune disruptions. Its precise impact on LBRs ART, however, remains controversial, studies presenting inconsistent outcomes. It uncertain whether directly reduces success or if confounding factors such as age embryo quality play more significant role. DESIGN, SIZE, DURATION This observational study included aged 18–42 years treatments freeze-all strategy from 1 January 2018 31 December 2022, each having at least one available transfer. The group consisted of patients confirmed diagnosis through pelvic MRI, interpreted by gynecologic radiologists. without who had idiopathic, tubal, and/or male factor infertility. PARTICIPANTS/MATERIALS, SETTING, METHODS A total 285 were included. These 1:1 based the number cryopreserved blastocysts, blastocysts. primary outcome was cumulative per patient single oocyte retrieval, secondary outcomes including clinical pregnancy rate (CPR) early miscarriage (EMR). Both univariate multivariate analyses conducted. MAIN RESULTS AND THE ROLE OF CHANCE In this study, controls. mean 35.4 ± 3.3 35.5 3.4 years, respectively, an average 3.5 2.5 3.6 2.6 blastocysts 0.4 0.7 0.5 respectively. group, MRI revealed internal diffuse 73.7% patients, adenomyoma 3.5%, external lesions 46.7%. significantly lower (41.4% versus 51.9%; odds ratio = 0.65, 95% CI [0.47–0.91]; P 0.012). Similarly, CPR (53.3% 63.9%; 0.011). No difference found EMR. Multivariate analysis, adjusted confounders indication, AMH levels, BMI, infertility type, procedure (IVF ICSI), identified independent risk (OR 0.7, [0.4–0.9]). findings indicate that associated rates. LIMITATIONS, REASONS FOR CAUTION Patients specialized referral center focusing management endometriosis potentially introducing selection bias, these may have severe forms adenomyosis. WIDER IMPLICATIONS FINDINGS For infertile women, it crucial practitioners conduct comprehensive imaging assessments detect Continued research needed refine personalize strategies affected condition. FUNDING/COMPETING INTEREST(S) funding received. P.V. co-editor-in-chief Journal Endometriosis Uterine Disorders. C.M. has received payments her institution Merck, Ferring, Theramex, Gedeon Richer, Besins, well direct Richter Ferring honoraria Merck Serono, IBSA, Organon meeting/travel support but no payment Richter. C.C. grants Richter, which paid his institution, he directly. He also attending meetings payment. founder past-president Society Disorders (SEUD), unpaid P.S. contracts him presentations lectures General Electric Medical Systems. travel IBSA. board member SEUD editorial RBMO GOF. C.P. Ferring. M.B. lectures/presentations. She not TRIAL REGISTRATION NUMBER Not applicable.

Language: Английский

Citations

0
Risk of endometriosis progression in infertile women trying to conceive naturally or using IVF DOI Creative Commons
Edgardo Somigliana, Paola Viganò,

Dalila Invernici

et al.

Human Reproduction, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Abstract The use of hormonal treatments for endometriosis has increased in recent years. Their effectiveness lies creating a stable environment, reducing peripheral estrogen levels, and suppressing ovulation menstruation. Although these agents do not cure symptoms often return after discontinuation, they effectively relieve pain most cases help prevent disease progression or recurrence. Women are therefore typically managed with long-term treatments, without surgery. However, this approach is unsuitable those seeking natural pregnancy undergoing IVF, as all hinder conception. For women pursuing pregnancy, should be discontinued about 1 year, the time needed to diagnose infertility. suspension exposes risk recurrence clinically acceptable only if woman reasonable likelihood achieving naturally. In who infertile require ovarian stimulation significantly raises levels—up 10 times cycle—potentially boosting relapse. Evidence reassuring on issue even some limited data suggest that may promote deep invasive progression. Overall, physicians patients must balance chances ART-assisted against during treatment discontinuation IVF. This choice also complicated by severe complications endometriosis, possibly depending conception method. review discusses available evidence can helpful guiding decision-making process.

Language: Английский

Citations

0
Endometriosis and Adenomyosis: Modern Concepts of Their Clinical Outcomes, Treatment, and Management DOI Open Access
Jessica Ottolina, Roberta Villanacci, Sara D’Alessandro

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(14), P. 3996 - 3996

Published: July 9, 2024

Endometriosis and adenomyosis are complex gynecological conditions characterized by diverse clinical presentations, including superficial peritoneal endometriosis (SPE), ovarian endometrioma (OMA), deep infiltrating (DIE). The hallmark features of these pathologies involve the manifestation pain symptoms infertility, approximately 30% patients asymptomatic. Despite ongoing research, definitive treatments for remain elusive, management primarily revolves around medical or surgical interventions. Recent advancements in our understanding efficacy various treatment modalities, therapy interventions, have provided clinicians with valuable insights into relief fertility preservation. This review aims to provide an updated overview latest literature on outcomes, options, strategies different types endometriosis. By synthesizing newest available data, this seeks inform guide decision making based factors such as patients’ symptom severity, childbearing desire, overall health.

Language: Английский

Citations

1
Endometriotic lesions express microRNAs that potentially regulate the transcription of hydroxysteroid 17-beta dehydrogenase 2 (HSD17B2): a pilot study DOI Creative Commons
Larissa Milani Coutinho, Caterina Bernacchioni, Maíra Casalechi

et al.

Journal of Endometriosis and Uterine Disorders, Journal Year: 2024, Volume and Issue: 8, P. 100093 - 100093

Published: Sept. 11, 2024

Language: Английский

Citations

1
Distribution of endometriosis phenotypes according to patients’ age in adult women with surgical evaluation DOI
Mathilde Bourdon,

Chloé Maignien,

Louis Marcellin

et al.

Human Reproduction, Journal Year: 2024, Volume and Issue: 39(10), P. 2259 - 2267

Published: Aug. 25, 2024

What is the distribution of endometriosis phenotypes according to age in adult women undergoing surgery?

Language: Английский

Citations

1
The Impact of Oxidized Regenerated Cellulose Application during Cystectomy and Drainage in Endometrioma Patients: A Retrospective Cohort Study DOI Creative Commons

Luky S Marwali,

Marcel Ezra Setiawan,

Malvin Emeraldi

et al.

Gynecology and Minimally Invasive Therapy, Journal Year: 2024, Volume and Issue: 14(1), P. 51 - 56

Published: Dec. 30, 2024

Abstract Objectives: This study aims to determine the impact of oxidized regenerated cellulose (ORC) during cystectomy and drainage on recurrence ovarian reserve. Materials Methods: Women aged 18–45 years with endometrioma (pathologically confirmed) who underwent conservative laparoscopy surgery (cystectomy drainage) using ORC at Fatmawati General Hospital Jakarta, Indonesia, were included in this study. All surgeries done by complete excision all endometriosis lesions (especially for deep infiltrating adenomyosis resection). patients followed up 1 year, rate postoperative anti-Mullerian Hormone (AMH) evaluated. Results: Twenty group 19 group. The researchers found result was not significant ( P = 0.622) rate. AMH decreased from 3.0 ± 1.8 2.1 1.5 Conversely, 1.4 1.25 1.1 0.9 reduction level more 0.002) than 0.124). Conclusion: Cystectomy significantly reduces Drainage insertion cyst cavity can be an option maintain reserve a risk that is different cystectomy.

Language: Английский

Citations

1