Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
38(8), P. 3973 - 3985
Published: June 7, 2024
Continuing
research
is
being
conducted
on
novel
preventive
and
therapeutic
drugs
for
cardiovascular
diseases
(CVDs).
Daidzein
has
shown
potential
beneficial
effects
regarding
various
CVDs
risk
factors.
However,
data
in
this
regard
are
inconsistent,
there
an
urge
to
accumulate.
Therefore,
we
reviewed
the
of
daidzein
daidzin
CVDs.
We
a
search
through
Scopus,
PubMed,
Google
Scholar,
Web
Science
from
inception
up
October
2023
find
studies
with
primary
intention
assessing
impacts
disease
vitro,
animal,
clinical
settings.
In
vitro
animal
showed
that
effective
terms
reducing
inflammation,
oxidative
stress,
hyperlipidemia,
myocardial
infarction,
thromboembolism,
hypertension,
aneurysms.
only
confirmed
relatively
small
portion
previous
findings
investigations,
including
anti-hyperlipidemic
effects.
conclusion,
have
reported
most
were
unable
exhibit
same
results.
Hence,
further
required
determine
outcomes
administering
its
derivatives
extended
period
doses.
Archiv der Pharmazie,
Journal Year:
2024,
Volume and Issue:
357(10)
Published: July 15, 2024
Abstract
Cardiovascular
diseases
(CVDs)
contribute
to
major
public
health
issues.
Some
studies
have
found
that
caffeic
acid
(CA)
and
phenethyl
ester
(CAPE)
may
effectively
prevent
or
treat
CVDs.
However,
there
is
a
need
sum
up
our
current
understanding
of
the
possible
beneficial
detrimental
effects
CA
CAPE
on
CVDs
related
mechanisms.
Therefore,
this
study
aimed
summarize
data
topic.
A
methodical
search
was
carried
out
key
databases,
including
Pubmed,
Google
Scholar,
Scopus,
Web
Science,
from
beginning
June
2024.
Studies
were
then
assessed
for
eligibility
based
inclusion
exclusion
criteria.
Treatment
with
significantly
positively
affected
cardiovascular
in
various
aspects,
atherosclerotic
diseases,
myocardial
infarction,
hypertension,
cardiac
arrhythmias,
hypercoagulation
state.
Several
mechanisms
proposed
mediate
these
effects,
transcription
factors
signaling
pathways
associated
antioxidant,
cytostatic,
anti‐inflammatory
processes.
several
via
multiple
during
prevention
treatment
promising
only
reported
through
vitro
animal
studies,
which
reinforces
further
evaluation
human
clinical
investigations.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(4), P. 454 - 454
Published: March 25, 2024
The
Serra
da
Estrela
Natural
Park
(NPSE)
in
Portugal
stands
out
as
a
well-preserved
region
abundant
medicinal
plants,
particularly
known
for
their
pharmaceutical
applications
diabetes
prevention
and
treatment.
This
comprehensive
review
explores
these
plants’
botanical
diversity,
traditional
uses,
pharmacological
applications,
chemical
composition.
NPSE
boast
rich
diversity
with
138
plants
across
55
families
identified
traditionally
pharmacologically
used
against
globally.
Notably,
the
Asteraceae
Lamiaceae
are
prevalent
antidiabetic
applications.
In
vitro
studies
have
revealed
significant
inhibition
of
carbohydrate-metabolizing
enzymes,
certain
plant
co-products
regulate
genes
involved
carbohydrate
metabolism
insulin
secretion.
vivo
trials
demonstrated
effects,
including
glycaemia
regulation,
secretion,
antioxidant
activity,
lipid
profile
modulation.
Medicinal
exhibit
various
activities
beyond
antidiabetic,
such
antioxidant,
anti-inflammatory,
antibacterial,
anti-cancer,
more.
Chemical
analyses
over
fifty
compounds
like
phenolic
acids,
flavonoids,
terpenoids,
polysaccharides
responsible
efficacy
diabetes.
These
findings
underscore
potential
candidates,
urging
further
research
to
develop
effective
plant-based
drugs,
beverages,
supplements.
ACS Omega,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 1, 2025
Hyperglycemia,
characterized
by
elevated
blood
glucose
levels,
is
a
major
risk
factor
for
diabetes
mellitus
and
its
complications.
While
conventional
therapies
are
effective,
they
often
associated
with
side
effects
high
costs,
necessitating
alternative
strategies.
This
study
evaluates
the
potential
of
caffeic
acid
(CA),
phenolic
compound
reported
antihyperglycemic
properties,
using
both
in
silico
vivo
approaches.
Molecular
docking
simulations
revealed
that
CA
demonstrates
strong
binding
affinity
to
protein
tyrosine
phosphatase
1B
(PTP1B),
critical
enzyme
metabolism,
superior
interaction
profiles
compared
reference
drug,
ertiprotafib.
In
studies,
Drosophila
melanogaster
model
was
used
investigate
under
hyperglycemic
conditions
induced
high-sugar
diet.
Treatment
CA,
particularly
at
concentration
500
μM,
significantly
reduced
hemolymph
levels
improved
several
physiological
behavioral
parameters,
including
survival
rates,
body
size,
weight,
larval
movement.
Furthermore,
gene
expression
analysis
demonstrated
modulates
key
metabolic
stress-related
pathways,
enhancing
homeostasis
reducing
stress.
These
findings
highlight
dual
utility
methodologies
elucidating
CA.
The
results
support
development
as
cost-effective
ethically
viable
therapeutic
candidate
implications
management
resource-limited
settings.
The
Serra
da
Estrela
Natural
Park
(NPSEs)
in
Portugal
stands
out
as
a
well-preserved
region
abundant
medicinal
plants,
particularly
known
for
their
pharmaceutical
applications
diabetes
prevention
and
treatment.
This
comprehensive
review
explores
these
plants'
botanical
diversity,
traditional
uses,
pharmacological
applications,
chemical
composition.
NPSEs
boast
rich
diversity
with
138
plants
across
55
families
identified
traditionally
pharmacologically
used
against
globally.
Notably,
the
Asteraceae
Lamiaceae
are
prevalent
anti-diabetic
applications.
In
vitro
studies
reveal
significant
inhibition
of
carbohydrate-metabolizing
enzymes,
certain
plant
co-products
regulate
genes
involved
carbohydrate
metabolism
insulin
secretion.
vivo
trials
demonstrate
effects,
including
glycaemia
regulation,
secretion,
antioxidant
activity,
lipid
profile
modulation.
Medicinal
NPSE
exhibit
various
activities
beyond
anti-diabetic,
such
antioxidant,
anti-inflammatory,
antibacterial,
anticancer,
more.
Chemical
analysis
identifies
over
fifty
compounds
like
phenolic
acids,
flavonoids,
terpenoids,
polysaccharides
responsible
efficacy
diabetes.
findings
underscore
potential
candidates,
urging
further
research
to
develop
effective
plant-based
drugs,
beverages,
supplements.
