Combination of ferulic acid and exercise alleviates menopause symptoms and skin remodeling in ovariectomized rats

Nutrition Research and Practice, Journal Year: 2025, Volume and Issue: 19(1), P. 30 - 30

Published: Jan. 1, 2025

Estrogen regulates certain biological functions, including bone health, maintenance of skin components, and cardiovascular brain protection. deficiency manifests as hot flashes, wrinkles, dryness, reduced mineral density (BMD), sleep disorders, diseases. This study aimed to investigate the effects aerobic exercise combined with ferulic acid (FA) in ovariectomized rats. Female Sprague-Dawley rats were classified into control (N), ovariectomy (OV), (OV+EX), (OV+EX+F) groups. Following at 22 weeks age, tower climbing gradually increase load (3 days/week for 12 weeks) or without FA (5 g/kg diet) administration. female (OV group) resulted increased body weight, blood triglyceride (TG) levels, decreased BMD following ovariectomy. Interestingly, compared OV group, OV+EX+F group exhibited weight TG levels maintained ovariectomy, similar those N group. Histological analysis estrogen-deficient revealed significantly thickness fewer dermal cells distorted subcutaneous fat layers, aging phenotype. rescued phenotypes OV+EX The from all groups was analyzed expression DNA damage repair proteins. enhanced protein pCHK1 (S345), an initiator signaling, p53, indicating cellular because ultimately underlying process. Exercise had beneficial on lipid profiles, BMD, remodeling during menopause.

Language: Английский

---

Small Phenolic Metabolites at the Nexus of Nutrient Transport and Energy Metabolism

Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1026 - 1026

Published: Feb. 24, 2025

Over time, human metabolism evolved to accommodate the challenges and benefits of plant foods that contain high amounts carbohydrates polyphenols. The latter are typically metabolized into small phenolic metabolites, including acids their endogenous microbial derivatives, influence interconnected metabolic pathways involved in nutrient transport, energy metabolism, neurotransmitter balance. Unlike other natural products, biological effects arise from weak interactions with multiple molecular rather than a single high-affinity receptor, making them versatile regulators health. These compounds also modulate glucose transporters carbohydrate playing crucial role postprandial insulin responses. This review addresses critical metabolites health, focus on homeostasis, sensitivity, metabolism. Incorporating polyphenols dietary strategies offers significant potential for improving reducing disorder risks, promoting whole-body homeostasis. Furthermore, understanding how interact is essential developing future effective nutritional support

Language: Английский

---

Antioxidant mechanism of ferulic acid and γ-oryzanol in emulsion and emulgel based on black seed oil

Food Chemistry X, Journal Year: 2025, Volume and Issue: 26, P. 102333 - 102333

Published: Feb. 1, 2025

The aim of this research was to compare the antioxidant mechanism ferulic acid and γ-oryzanol in emulsion with that emulgel. In initiation phase, at 2.32 mM concentration exhibited best efficiency emulgel samples, while efficiency. γ-Oryzanol more effective than samples propagation phase. participated side reactions chain addition participating major termination reaction. both showed higher consumption rate constant extent participation γ-oryzanol. conclusion,

Language: Английский

---

Housed feeding improves rumen health by influencing the composition of the microbiota in Honghe cattle

Frontiers in Veterinary Science, Journal Year: 2025, Volume and Issue: 12

Published: March 10, 2025

Rumen is one of the most vital organs for digestion ruminants and influenced by factors including feeding patterns nutrition. How rumen microbiota barrier function change are affected requires attention, particularly beef cattle. In present study, Honghe cattle under grazing (CON group, n = 10) housed (HES conditions were selected as a model different observed 180 days. The indicators immunity antioxidants in serum epithelium measured; evaluated using 16S rRNA ITS sequencing techniques. concentrations total protein, albumin glucose significantly increased HES group when compared with CON ( p < 0.05). reduced levels complement 3, 4, interleukin-4, interleukin-10, interleukin-1β tumor necrosis factor α , but antioxidant capacity (T-AOC) superoxide dismutase (SOD) We found that enhanced T-AOC SOD Furthermore, there was significant up-regulation relative mRNA expressions ZO-1 OCC SOD1 SOD2 Nrf2 NQO-1 HO-1 For microbiota, decreased alpha diversity. core bacterial communities Bacteroidata, Firmicutes Proteobacteria. abundances Prevotella Ruminococcus norank_f_Bacteroidales_UCG-001 Rikenellaceae_RC9_gut_group Prevotellaceae_UCG-003 Moreover, abundance Pichia Cyllamyces Sterigmatomyces Wallemia 0.05), Aspergillus Candida There positive correlation between microorganisms such epithelial antioxidant-related genes Overall, contributed to improvement health cattle, which may be related modulation bacteria fungi.

Language: Английский

---

Total dietary fiber of tartary buckwheat alleviates T2DM through the IRS-1/PI3K/AKT pathway and gut microbiota-bile acids-TGR5/FXR axis in db/db mice

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142145 - 142145

Published: March 1, 2025

Language: Английский

---

The impact of supplementation with highland barley in different nutrients on weight loss: The nutrients and function relationship

Food Chemistry X, Journal Year: 2025, Volume and Issue: 27, P. 102417 - 102417

Published: March 28, 2025

The dietary fiber in highland barley (HB) may be a key nutrient exerting its physiological functions. How about the effects of other nutrients? In this study, high-fat diet (HFD)-induced obese mice was constructed to investigate HB different nutrients on weight loss. results showed that peeling treatment had varying nutrients. Consumption significantly mitigated gain, postprandial blood glucose levels, organ weight, adipose tissue and fat accumulation mice. also ameliorated hepatic steatosis, hyperlipemia, abnormal liver function, dysregulation inflammatory factor expression Unpeeled once peeled presented best effect. Furthermore, consumption improved imbalance gut microbiota HFD-induced mice, with protein being factors improvement This study highlights potential for treating obesity.

Language: Английский

---

The mutual effect of dietary fiber and polyphenol on gut microbiota: Implications for the metabolic and microbial modulation and associated health benefits

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 358, P. 123541 - 123541

Published: March 30, 2025

Language: Английский

---

Deciphering the effect of soluble dietary fiber from broccoli stem and leaf on metabolic syndrome and its hypoglycemic mechanism in diabetes mellitus

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106546 - 106546

Published: April 1, 2025

Language: Английский

---

Cordyceps polysaccharide improves polycystic ovary syndrome by inhibiting gut-derived LPS/TLR4 pathway to attenuates insulin resistance

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 135844 - 135844

Published: Sept. 1, 2024

Language: Английский

---

Effects of Phenolic Acids Produced from Food-Derived Flavonoids and Amino Acids by the Gut Microbiota on Health and Disease

Molecules, Journal Year: 2024, Volume and Issue: 29(21), P. 5102 - 5102

Published: Oct. 29, 2024

The gut microbiota metabolizes flavonoids, amino acids, dietary fiber, and other components of foods to produce a variety microbiota-derived metabolites. Flavonoids are the largest group polyphenols, approximately 7000 flavonoids have been identified. A phenolic acids produced from through metabolic processes by microbiota. Furthermore, these easily absorbed. Phenolic generally represent compounds with one carboxylic acid group. Gut antiviral effects against several viruses, such as SARS-CoV-2 influenza. influence immune system inhibiting secretion proinflammatory cytokines, interleukin-1β tumor necrosis factor-α. In nervous systems, may protective neurodegenerative diseases, Alzheimer’s Parkinson’s diseases. Moreover, can improve levels blood glucose, cholesterols, triglycerides. also cardiovascular functions, pressure atherosclerotic lesions. This review focuses on current knowledge food-derived health disease.

Language: Английский

---