Immunoregulatory Effects of Codonopsis pilosula Polysaccharide Modified Selenium Nanoparticles on H22 Tumor-Bearing Mice DOI Creative Commons
Yan Long, Hongfei Ji,

Jiajing Yang

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(24), P. 4073 - 4073

Published: Dec. 17, 2024

Codonopsis pilosula polysaccharide (CPP) and rare element selenium (Se) have been proved to exert various biological activities, our previous study demonstrated that nanoparticles modified with CPP (CPP-SeNPs) possessed significantly enhanced tumor cytotoxicity in vitro. This aimed investigated the inhibitory effects of CPP-SeNPs complex on H22 solid tumors via immune enhancement. In this study, tumor-bearing mice model was constructed, potential mechanisms antitumor were further explored by evaluating cytokines expression levels, cells activities apoptotic indicators each group. The results effectively exerted dose-dependent protective organs vivo, leading increase peripheral white blood cell counts inhibition growth rate 47.18% high-dose group (1.5 mg/kg). Furthermore, treatment elevated levels TNF-α, IFN-γ, IL-2 sera, NK cytotoxicity, augmented macrophage phagocytosis capacity, as well increased both amounts proliferation activity lymphocyte subsets. improved system’s ability clear up-regulating Bax while down-regulating Bcl-2 within tumors, indicating activation mitochondrial apoptosis pathway. Therefore, administration can inhibit enhancing response mice, which might be relevant regulation gut microbiota short-chain fatty acids metabolisms. These findings could provide theoretical support data foundation for development functional food drug adjuvants.

Language: Английский

Protective effects of herbal compounds against cyclophosphamide-induced organ toxicity: a pathway-centered approach DOI

Prathap Srirangan,

Evan Prince Sabina

Drug and Chemical Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 43

Published: Jan. 23, 2025

Cyclophosphamide is a key component of numerous chemotherapeutic protocols, demonstrating broad-spectrum efficacy against various malignancies and non-cancerous conditions. This review examines CPM's metabolic pathways, therapeutic applications, its resulting organ-specific toxicities. Despite clinical benefits in treating nephrotic syndrome, encephalomyelitis, breast cancer, ovarian other diseases, CPM associated with significant adverse effects on the kidneys, liver, heart, lungs, intestines. The discussion delves into molecular mechanisms underlying these toxicities, highlighting dysregulation signaling including Nrf2, NF-κB, MAPK/ERK, AKT. In addressing challenges, recent studies have identified herbal drugs phytochemicals capable mitigating CPM-induced toxicity. Notable compounds such as cinnamaldehyde, baicalin, quercetin, curcumin demonstrated protective effects. Integrating formulations therapy proposed to enhance patient safety treatment efficacy. underscores influence apoptosis inflammation which lead alterations biomarkers. Phytochemicals may exert by restoring disrupted pathways normalizing altered compilation presented this serves valuable resource for researchers exploring products potential A gap current literature lack trials evaluating that mitigate toxicity vivo. Rigorous are necessary establish cancer treatment. Such research will clarify role natural remedies complementing conventional therapies, ultimately improving outcomes.

Language: Английский

Citations

1
Immunostimulating effects of ulvan type polysaccharide isolated from Korean Ulva pertusa in cyclophosphamide-induced immunosuppressed BALB/c mice DOI
Seung‐U Son, Tae Eun Kim,

Ju-Hyeon Park

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 275, P. 133518 - 133518

Published: July 1, 2024

Language: Английский

Citations

6
Date Pomace Polysaccharides-Capped Selenium Nanoparticles: Biosynthesis, Optimization, Physicochemical Characterization, Biological Activities, Stability and Gut Microbiota Modulation DOI Creative Commons
Gafar Babatunde Bamigbade, Athira Jayasree Subhash, M. Z. Abdin

et al.

Food Hydrocolloids for Health, Journal Year: 2025, Volume and Issue: unknown, P. 100198 - 100198

Published: Jan. 1, 2025

Language: Английский

Citations

0
Polysaccharides of Melientha longistaminea regulates immune function and gut microbiota in cyclophosphamide (CTX)-induced immunosuppressed mice DOI
Yan Zhang, Hui Wang,

Ge Qin

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 156, P. 114702 - 114702

Published: April 27, 2025

Language: Английский

Citations

0
Pleurocinus ostreatus Polysaccharide Alleviates Cyclophosphamide-Induced Immunosuppression through the Gut Microbiome, Metabolome, and JAK/STAT1 Signaling Pathway DOI Creative Commons

Daiyao Liu,

Abdul Mueed, He Ma

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(17), P. 2679 - 2679

Published: Aug. 25, 2024

This study investigated the structure of

Language: Английский

Citations

2
The protective effect of Auricularia auricula polysaccharides on cyclophosphamide-induced immunosuppression and intestinal injury: A fecal microbiota transplantation study DOI
Tianci Wang,

Zikun Jia,

Canghai An

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 62, P. 105416 - 105416

Published: Nov. 5, 2024

Language: Английский

Citations

2
Immunoregulatory Effects of Codonopsis pilosula Polysaccharide Modified Selenium Nanoparticles on H22 Tumor-Bearing Mice DOI Creative Commons
Yan Long, Hongfei Ji,

Jiajing Yang

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(24), P. 4073 - 4073

Published: Dec. 17, 2024

Codonopsis pilosula polysaccharide (CPP) and rare element selenium (Se) have been proved to exert various biological activities, our previous study demonstrated that nanoparticles modified with CPP (CPP-SeNPs) possessed significantly enhanced tumor cytotoxicity in vitro. This aimed investigated the inhibitory effects of CPP-SeNPs complex on H22 solid tumors via immune enhancement. In this study, tumor-bearing mice model was constructed, potential mechanisms antitumor were further explored by evaluating cytokines expression levels, cells activities apoptotic indicators each group. The results effectively exerted dose-dependent protective organs vivo, leading increase peripheral white blood cell counts inhibition growth rate 47.18% high-dose group (1.5 mg/kg). Furthermore, treatment elevated levels TNF-α, IFN-γ, IL-2 sera, NK cytotoxicity, augmented macrophage phagocytosis capacity, as well increased both amounts proliferation activity lymphocyte subsets. improved system’s ability clear up-regulating Bax while down-regulating Bcl-2 within tumors, indicating activation mitochondrial apoptosis pathway. Therefore, administration can inhibit enhancing response mice, which might be relevant regulation gut microbiota short-chain fatty acids metabolisms. These findings could provide theoretical support data foundation for development functional food drug adjuvants.

Language: Английский

Citations

1