Unveiling the Dynamics of Antimicrobial Resistance: A Year-Long Surveillance (2023) at the Largest Infectious Disease Profile Hospital in Western Romania DOI Creative Commons
Sorina Maria Denisa Laitin, Luminița Bădițoiu,

Ruxandra Laza

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 13(12), P. 1130 - 1130

Published: Nov. 25, 2024

Background/Objectives: Antimicrobial resistance (AMR) is a critical global health threat, leading to increased morbidity, mortality, and healthcare costs. This study aimed identify the most common bacterial pathogens their profiles from 2179 positive clinical cultures inpatients at “Victor Babes” Hospital of Infectious Disease Pneumoftiziology Timisoara in 2023. Methods: Samples were collected sputum, bronchial aspiration, hemoculture, urine, wound secretions, catheter samples, other specimens. Results: Key identified included Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter baumannii, with notable patterns, observed K. pneumoniae exhibited high rates, notably 41.41% Quarter 1, while E. coli showed 35.93% same period. S. particularly MRSA, remained persistent challenge, 169 cases recorded over year. A. baumannii P. aeruginosa displayed alarming levels multi-drug resistance, especially 3 (88.24% 22.02%, respectively). Although there was general decline rates by 4, such as aureus continued exhibit significant (81.25% 21.74%, Conclusions: The study’s findings align broader antimicrobial trends Romania, where (MRSA), Acinetobacter, species have been widely reported, reflecting country’s ongoing struggle multi-drug-resistant infections. Despite some reductions across quarters, presence these resistant strains underscores need for strengthened stewardship, infection control measures, continuous surveillance combat growing threat AMR Romania similar settings.

Language: Английский

Unveiling soil-borne antibiotic resistome and their associated risks: A comparative study of antibiotic and non-antibiotic pharmaceutical factories DOI

Liusheng Lei,

Jing Yu,

Linjia Liu

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 486, P. 137127 - 137127

Published: Jan. 5, 2025

Language: Английский

Citations

1
Systematic review and meta-analysis on the carbapenem-resistant hypervirulent Klebsiella pneumoniae isolates DOI Creative Commons

Motahareh Sabaghi Qala Nou,

Zahra Amirian, Fatemeh Dehghani

et al.

BMC Pharmacology and Toxicology, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 30, 2025

The global dissemination of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKp) poses a critical threat to public health. However, comprehensive data on the prevalence and resistance rates CR-hvKp are limited. This systematic review meta-analysis aim estimate pooled carbapenem among hvKp strains assess distribution carbapenemase genes. A search ISI Web Science, PubMed, Google Scholar was conducted identify studies reporting in strains. genes calculated using event with 95% confidence intervals. total 36 encompassing 1,098 were included. 49% for imipenem, 53.2% meropenem, 38.2% ertapenem. Carbapenemase gene 19.1% blaVIM, 22.0% blaNDM, 43.4% blaOXA-48, 58.8% blaKPC. high widespread underscore their significant These findings highlight urgent need enhanced surveillance, rapid diagnostic tools, stringent infection control measures mitigate spread CR-hvKp. Future research should focus understanding mechanisms developing targeted therapeutic strategies address this challenge.

Language: Английский

Citations

0
Unveiling the Dynamics of Antimicrobial Resistance: A Year-Long Surveillance (2023) at the Largest Infectious Disease Profile Hospital in Western Romania DOI Creative Commons
Sorina Maria Denisa Laitin, Luminița Bădițoiu,

Ruxandra Laza

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 13(12), P. 1130 - 1130

Published: Nov. 25, 2024

Background/Objectives: Antimicrobial resistance (AMR) is a critical global health threat, leading to increased morbidity, mortality, and healthcare costs. This study aimed identify the most common bacterial pathogens their profiles from 2179 positive clinical cultures inpatients at “Victor Babes” Hospital of Infectious Disease Pneumoftiziology Timisoara in 2023. Methods: Samples were collected sputum, bronchial aspiration, hemoculture, urine, wound secretions, catheter samples, other specimens. Results: Key identified included Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter baumannii, with notable patterns, observed K. pneumoniae exhibited high rates, notably 41.41% Quarter 1, while E. coli showed 35.93% same period. S. particularly MRSA, remained persistent challenge, 169 cases recorded over year. A. baumannii P. aeruginosa displayed alarming levels multi-drug resistance, especially 3 (88.24% 22.02%, respectively). Although there was general decline rates by 4, such as aureus continued exhibit significant (81.25% 21.74%, Conclusions: The study’s findings align broader antimicrobial trends Romania, where (MRSA), Acinetobacter, species have been widely reported, reflecting country’s ongoing struggle multi-drug-resistant infections. Despite some reductions across quarters, presence these resistant strains underscores need for strengthened stewardship, infection control measures, continuous surveillance combat growing threat AMR Romania similar settings.

Language: Английский

Citations

1