Science China Life Sciences, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 20, 2024
Language: Английский
Science China Life Sciences, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 22, 2025
Language: Английский
Citations
4
Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1), P. 10001 - 10001
Published: Jan. 1, 2025
Trace DNA represents a critical form of forensic evidence, frequently recovered from wide variety touched or used items. Despite its evidentiary value, trace analysis poses significant challenges due to the minute quantities involved, as well influence factors such surface type, collection methods, and environmental exposure. This study systematically examines success rates characteristics profiles six-item categories—tools, stolen items, wearable packaging materials, vehicles, items—processed between 2021 2023 by Biology Section Dubai Police Force. A total 6277 cases were analyzed, encompassing range crimes, including homicide, suicide, missing persons, paternity disputes, burglary. The results demonstrated an overall rate 64%, with items yielding highest at 76% materials lowest 54%. Detailed positive samples revealed variability in profile types across item categories. Wearable predominantly yielded full single (FS) profiles, reflecting their reliability sources singular high-quality DNA. Conversely, showed greater prevalence mixed (FM) highlighting association complex mixtures handling multiple contributors. Tools meanwhile, exhibited higher partial presenting unique related irregularities factors. emphasizes importance tailoring strategies item-specific characteristics, need for systematic mechanisms categorize samples. Addressing operational manual sorting leveraging automation AI-based systems can further streamline analysis. findings also underscore data sharing standardization laboratories enhance recovery protocols improve investigations. Future research should focus on effects material properties, exposure, techniques retention, advancing field profiling applications science.
Language: Английский
Citations
0
Forensic Science International, Journal Year: 2025, Volume and Issue: 367, P. 112370 - 112370
Published: Jan. 12, 2025
Language: Английский
Citations
0
BMC Biology, Journal Year: 2025, Volume and Issue: 23(1)
Published: Jan. 21, 2025
The advancements in second-/third-generation sequencing technologies, alongside computational innovations, have significantly enhanced our understanding of the genomic structure Y-chromosomes and their unique phylogenetic characteristics. These researches, despite challenges posed by lack population-scale databases, potential to revolutionize approach high-resolution, population-specific Y-chromosome panels databases for anthropological forensic applications. This study aimed develop highest-resolution Y-targeted panel, utilizing time-stamped, core informative mutations identified from high-coverage sequences YanHuang cohort. panel is intended provide a new tool complex pedigree search paternal biogeographical ancestry inference, as well explore general patterns fine-scale evolutionary history ethnolinguistically diverse Chinese populations. performance East Asian-specific Y-chromosomal including 2999-core SNP variants, was found be robust reliable. YHSeqY3000 designed capture genetic diversity lineages 3500 years ago, identifying 408 terminal 2097 individuals across 41 genetically geographically distinct We substructure that correlating with ancient population migrations expansions. New evidence provided extensive gene flow events between minority ethnic groups Han people, based on integrative Paternal Genomic Diversity Database. work successfully integrated Y-chromosome-related basic science translational applications, emphasizing necessity comprehensively characterizing genomically under-representative particularly important second phase medical or cohorts, where dense sampling strategies are employed.
Language: Английский
Citations
0
Forensic Science International Genetics, Journal Year: 2025, Volume and Issue: 76, P. 103225 - 103225
Published: Jan. 27, 2025
Language: Английский
Citations
0
SSRN Electronic Journal, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Frontiers in Ecology and Evolution, Journal Year: 2025, Volume and Issue: 13
Published: April 3, 2025
Biogeographical ancestry inference offers valuable clues for forensic cold cases, but limited information is typically obtained from substructured populations within continental East Asian and Southeast groups. This study presents an integrative genomic dataset of 3,461 individuals Asia to elucidate the fine-scale population substructure its role in precision medicine. Six nested panels were developed with increasing ancestry-informative marker (AIM) density (ranging 50 2,000 SNPs) distinguish fine genetic differences between six language groups Sino-Tibetan family. We found that 2000 AIM panel exhibited differentiation efficiency PCA comparable all loci. Additionally, we constructed a classification machine learning model average prediction accuracy 84%, highlighting critical geographical improving accuracy. Furthermore, validated deep method Locator predicting coordinates solely based on information. work highlights power integrating geographic data artificial intelligence refine biogeographical inference, offering more profound insights into structure Asia, significant implications applications.
Language: Английский
Citations
0
The Innovation Life, Journal Year: 2025, Volume and Issue: unknown, P. 100131 - 100131
Published: Jan. 1, 2025
<p>Large-scale genomic resources from biobank sequencing projects are crucial for understanding the interplay between environmental and genetic factors in human disease health traits, as well reconstructing evolutionary history. We summarize recent advances cohorts highlight opportunities non-Eurocentric populations a multidisciplinary perspective. Initiatives like UK100K, All of Us, TOPMed precision medicine programs have shifted research paradigms problem-derived to data-driven approaches, enhancing our architecture diseases Europeans their descendants. However, biases persist, such Han bias Chinese focused on medical anthropological purposes. These contribute global inequalities disparities medicine. Evolutionary studies modern ancient genomes provide new insights into history adaptive trajectories critical mutations. findings underscore importance personal genome tailored ethnolinguistically genetically diverse populations. This strategy is vital assessing burden etiology disease. Our work emphasizes need include underrepresented diversity create comprehensive catalog variations understand biological implications.</p>
Language: Английский
Citations
0
Journal of genetics and genomics/Journal of Genetics and Genomics, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Citations
2
iScience, Journal Year: 2024, Volume and Issue: 27(12), P. 111456 - 111456
Published: Nov. 22, 2024
Language: Английский
Citations
1