Comparative Polyphenol Composition, Antioxidant and Anticorrosion Properties in Various Parts of Panax ginseng Extracted in Different Solvents

Applied Sciences, Journal Year: 2020, Volume and Issue: 11(1), P. 93 - 93

Published: Dec. 24, 2020

Panax ginseng C.A. (P. ginseng) Meyer has been in use since ancient times for its therapeutic activities. Although several studies have investigated the roles of phytoconstituents human and animal health, no comparative conducted to test efficacy P.ginseng leaf, fruit root. Therefore, this study aimed identify antioxidant anticorrosion activities prepared using five different solvents. The methanolic extract showed comparatively good activity all assays. total phenolic content (TPC) was higher (95.21 mg/g), followed by leaf (39.21 mg/g) extracted methanol solvent compared other flavonoid (TFC) 50.21 mg/g, which ethanol (41.33 mg/g). same phenomenon observed studies. Through Ultrahigh Performance Liquid Chromatography (UHPLC), presence 23 components categorized as hydroxycinnamic acids, hydroxybenzoic acids a few groups that play vital role antioxidation identified. Phenols such chlorogenic acid (1002.2 μg/g), gentisic (854.21 μg/g) rutin (165.32 were found amounts whereas significant m-coumaric (185.32 p-coumaric (125.24 μg/g). anti-corrosive property with analyzed copper specimen exposed 1 M HCl medium 96% corrosion inhibition efficiency at 1000-ppm concentration. smooth surface corrosive media shown field emission scanning electron microscope (FESEM) image confirms protected from corrosion, energy-dispersive X-ray spectroscopy (EDX) spectra show loss Cu is reduced inhibited metal surface. Atomic force microscopy (AFM) images roughness factor also validate characteristic plant extract.

Language: Английский

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The Role of Thymoquinone in Inflammatory Response in Chronic Diseases

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(18), P. 10246 - 10246

Published: Sept. 6, 2022

Anti-inflammatory therapies have been shown to be effective in the prevention of various cardiovascular diseases, tumors, and cancer complications. Thymoquinone (TQ), main active constituent Nigella sativa, has promising therapeutic properties many vivo vitro models. However, TQ poor bioavailability is hydrophobic, prohibiting clinical trials with alone. Studies explored combination biological nanomaterials improve its bioavailability. The nanoparticle formulation shows better than free TQ, these formulations are ready for determine their potential as agents. In this paper, we review current knowledge about interaction between inflammatory response summarize research prospects Korea abroad. We discuss different activities trials.

Language: Английский

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Exploring the interplay of natural products and long non-coding RNAs in colorectal cancer: pathogenesis, diagnosis, and overcoming drug resistance

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

Language: Английский

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Influence of light quality on the profiling of metabolites and the status of Lactobacillus community in the phyllosphere of hydroponically grown ginseng

Chemical and Biological Technologies in Agriculture, Journal Year: 2025, Volume and Issue: 12(1)

Published: Jan. 13, 2025

The microbial community within the phyllosphere plays a critical role in plant health and growth by facilitating nutrient uptake, inducing resistance enhancing tolrance to stress. Environmental factors, such as light intensity quality, are known influence composition function of microbiota. In hydroponic systems, these interactions particularly relevant, they can significantly affect yield. Based on potential controlled environments shape both responses, impact different conditions microbiota is crucial for productivity. This study evaluated two Korean ginseng varieties exposed LED treatments system. Metabolite profiling ginsenoside content were analysed, while bacterial abundance was quantified. Detailed insights into obtained through 16S rRNA sequencing. A multivariate analysis performed distinguish effects Carbohydrates most abundant with flouresence (FL), blue (BL), red (RD), dark (DK), infrared (IR), ultraviolet (UV) exhibited higher levels amino acids organic acids. Minor Gumpoong (V2) variety compared Yunpoong (V1). Light had direct microbiota, specific microorganisms being associated each under exposures. Organic positively influenced Proteobacteria, Actinobacteria, Chloroflexi, Ni-trospirae, Firmicutes, Acidobacteria, Planctomycetes, Cyanobacteria correlated carbohydrate levels. Proteobacteria remained stable IR treatment, constituting over 80% V2 60% V1, UV promoted stability fostered more diverse ecosystems characterized richness Lactiplantibacillus plantarum only lactic acid bacterium detected varieties, V2, indicating its ubiquity across types. Current findings showed that metabolite profiles hydroponically grown ginseng. Specific conditions, blue, red, infrared, distinct communities enhanced production key metabolites, including carbohydrates, acids, ginsenosides. presence L. plantarum, highlights functional food probiotic properties. provides valuable optimizing cultivation microbiome health.

Language: Английский

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Caesalpinia sappan L. ethyl acetate extract regulated angiogenesis in atherosclerosis by modulating the miR-126/VEGF signalling pathway

Heliyon, Journal Year: 2025, Volume and Issue: 11(3), P. e42159 - e42159

Published: Jan. 23, 2025

To investigate the regulatory mechanism of Caesalpinia sappan L. ethyl acetate extract (CSEAE) on angiogenesis in atherosclerosis (AS) based miR-126/VEGF signalling pathway. Our study first screened for differentially expressed microRNAs (miRNAs) associated with AS using Gene Expression Omnibus (GEO) public database at National Center Biotechnology Information (NCBI) and R language software. Subsequently, our verified target-regulatory relationship between miR-126 vascular endothelial growth factor (VEGF) human umbilical vein cells (HUVECs) by "TargetScan" website dual-luciferase reporter assay. In cellular experiments, used cell proliferation assays flow cytometry to assess effects CSEAE-Mediated serum apoptosis HUVECs. animal HE staining, Oil Red O staining immunohistochemistry (IHC) detect plaque area/lumen area (%), lipid area/plaque (%) microvessel density (MVD) mouse aortas. addition, performed RT‒PCR, ELISA Western blot ex vivo experiments. A total 39 miRNAs were identified, among which expression level was significantly downregulated. Dual luciferase gene assay results showed that VEGF have a targeting relationship, mimic could inhibit activity wild-type vector (p value < 0.01). increased proliferative after 24-72 h treatment (p-value <0.01) decreased apoptotic HUVECs 0.01), RT‒PCR upregulated 0.01) downregulated mRNA IHC CSEAE reduced MVD aorta plaques mice aortic Moreover, analysis protein levels phosphatidyl-inositol-3-kinase (PI3K) Ser/Thr-protein kinase (AKT1) aortas, while receptor (VEGFR2) hypoxia-inducible factor-1 (HIF-1) mice. This emphasises as natural medicinal can improve migratory viability reduce maintain health arterial microenvironment, also inhibits delays formation ApoE-/- mice, suggesting therapeutic effect may be related its inhibition neovascularisation molecular

Language: Английский

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