Journal of Cardiovascular Development and Disease,
Journal Year:
2022,
Volume and Issue:
9(12), P. 428 - 428
Published: Dec. 1, 2022
Dietary
cholesterol
accelerates
oxidative
and
pro-inflammatory
processes,
causing
hypercholesterolemia
cardiovascular
diseases.
Thus,
the
purpose
of
current
study
is
to
compare
protective
effects
thymoquinone
(TQ)
alone
or
in
combination
with
losartan
(LT)
against
heart
damage
caused
by
a
high-cholesterol
diet
(HCD).
HCD-fed
rat
groups
revealed
an
elevated
activity
indicators
cardiac
enzymes
serum.
Serum
lipids
were
also
found
be
significantly
higher
groups.
Cardiac
markers
increased
groups,
whereas
antioxidant
decreased.
However,
all
these
biochemical,
inflammatory,
antioxidant,
change
returned
levels
similar
those
normal
rats
after
treatment
TQ
LT
administered
Hypercholesterolemia
considerably
induced
lipid
peroxidation
product,
thiobarbituric
acid
reaction
substances
(TBARs),
radicals
cells,
which
attenuated
QT
treatments,
particularly
when
combined.
Finally,
QT,
LT,
their
able
reduce
histological
changes
brought
on
excess
tissues.
In
conclusion,
administration
has
better
effect,
reduced
hypercholesterolemic-induced
inflammatory
that
occurred
tissue.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 3, 2025
Chronic
obstructive
pulmonary
disease
(COPD)
is
a
prevalent
chronic
respiratory
worldwide.
Mitochondrial
quality
control
mechanisms
encompass
processes
such
as
mitochondrial
biogenesis,
fusion,
fission,
and
autophagy,
which
collectively
maintain
the
quantity,
morphology,
function
of
mitochondria,
ensuring
cellular
energy
supply
progression
normal
physiological
activities.
However,
in
COPD,
due
to
persistent
stimulation
harmful
factors
smoking
air
pollution,
often
become
deregulated,
leading
dysfunction.
dysfunction
plays
pivotal
role
pathogenesis
contributing
toinflammatory
response,
oxidative
stress,
senescence.
therapeutic
strategies
targeting
mitochondria
remain
underexplored.
This
review
highlights
recent
advances
focusing
on
their
dysregulation
progression.
We
emphasize
significance
pathophysiological
COPD
explore
potential
regulate
improve
through
interventions,
aiming
treat
effectively.
Additionally,
we
analyze
limitations
challenges
existing
strategies,
provide
new
insights
methods
for
treatment.
Life,
Journal Year:
2023,
Volume and Issue:
13(2), P. 402 - 402
Published: Feb. 1, 2023
A
complex
network
of
processes
inside
the
human
immune
system
provides
resistance
against
a
wide
range
pathologies.
These
defenses
form
an
innate
and
adaptive
immunity,
in
which
certain
components
work
together
to
counteract
infections.
In
addition
inherited
variables,
susceptibility
diseases
may
be
influenced
by
factors
such
as
lifestyle
choices
aging,
well
environmental
determinants.
It
has
been
shown
that
dietary
chemical
regulate
signal
transduction
cell
morphologies
which,
turn,
have
consequences
on
pathophysiology.
The
consumption
some
functional
foods
increase
activity,
defending
us
number
diseases,
including
those
caused
viruses.
Here,
we
investigate
foods,
often
marketed
boosters,
attempt
find
indications
their
potential
protective
role
viruses,
influenza
viruses
(A
B),
herpes
simplex
virus
(HSV),
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2),
cases
mediated
gut
microbiota.
We
also
discuss
molecular
mechanisms
govern
effects
constituents.
main
message
this
review
is
discovering
are
able
strengthen
can
winning
weapon
viral
diseases.
addition,
understanding
how
function
aid
development
novel
strategies
for
maintaining
bodily
health
keeping
our
systems
strong.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(24), P. 13410 - 13410
Published: Dec. 14, 2024
Nigella
sativa
(NS)
is
an
annual
herb
belonging
to
the
Ranunculaceae
family,
also
known
as
black
cumin
or
seed.
This
plant
has
been
used
since
ancient
times
due
its
therapeutic
properties
and
proven
effective
in
gastrointestinal,
respiratory,
cardiovascular,
infectious,
inflammatory
conditions.
In
this
review,
aim
highlight
effects
of
Arab
countries
“the
that
cures
any
disease”,
which
are
provided
by
phytochemical
compounds
composition,
such
thymoquinone,
p-cymene,
α-thujene,
longifolene,
β-pinene,
α-pinene,
carvacrol.
These
confer
antioxidant
effect
seeds,
leading
a
significant
decrease
ROS
potent
anti-inflammatory
effect.
Also,
NS
seeds
may
have
synergistic
with
other
drugs,
chemotherapeutic
agents
antibiotics,
lead
reduction
dose,
improved
effect,
could
overcoming
obstacles
drug
resistance.
The
studies
review
showed
potential
be
agent
both
monotherapy
adjuvant.
Although
there
demonstrating
NS,
need
for
much
more
extensive
research
clinical
trials
clearly
established
objectives
so
mechanism
action
active
substances
better
understood.
With
data
far,
can
food
production
small
quantities
administered
short
periods.
Further
investigations
understanding
profile
most
mode
administration,
well
clearer
perspective
on
toxicological
NS.
Frontiers in Oncology,
Journal Year:
2023,
Volume and Issue:
12
Published: Jan. 4, 2023
Pancreatic
cancer
has
one
of
the
worst
prognoses
among
most
common
cancers
in
world.
Its
characteristics
include
a
high
rate
metastasis
and
chemotherapeutic
resistance,
which
present
major
challenges
to
medical
community.
The
potential
anticancer
effects
thymoquinone
(TQ),
is
main
bioactive
compound
black
seeds
Nigella
sativa
plant,
have
recently
received
widespread
attention
for
their
use
treating
pancreatic
cancer.
TQ
can
inhibit
cell
proliferation,
promote
apoptosis,
invasion
metastasis,
enhance
sensitivity,
angiogenesis,
exert
anti-inflammatory
effects.
These
predominantly
involve
nuclear
factor
(NF)-κB,
phosphoinositide
3
kinase
(PI3K)/Akt,
Notch,
transforming
growth
(TGF)-β,
c-Jun
N-terminal
(JNK),
p38
mitogen-activated
protein
(MAPK)
signaling
pathways
as
well
regulation
cycle,
matrix
metallopeptidase
(MMP)-9
expression,
pyruvate
isozyme
type
M2
(PKM2)
activity.
regulates
occurrence
development
at
multiple
levels
through
targets
that
communicate
with
each
other.
In
this
review,
we
summarize
discuss
analogs
carriers
been
developed
recent
years.
Given
its
multilevel
effects,
may
become
new
therapeutic
drug
future.
This
review
presents
brief
introduction
research
conducted
on
relation
provide
theoretical
basis
future
studies
topic.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(24), P. 15904 - 15904
Published: Dec. 14, 2022
Hepatocellular
carcinoma
(HCC)
is
characterized
by
its
high
vascularity
and
metastasis.
Thymoquinone
(TQ),
the
main
bio-active
constituent
of
Nigella
sativa,
has
shown
anticancer
hepatoprotective
effects.
TQ's
effect
mediated
through
miRNA
regulation.
miR-1-3p
plays
a
significant
role
in
various
cancers
but
HCC
invasiveness
remains
poorly
understood.
Bio-informatics
analysis
predicted
that
3'-UTR
TIMP3
target
for
miR-1-3p;
Rats
were
equally
divided
into
four
groups:
Group
1,
negative
control;
2
received
TQ;
3
DEN;
4
DEN
after
pretreatment
with
TQ.
The
expression
TIMP3,
MMP2,
MMP9,
VEGF
rats'
liver
was
determined
immunohistochemically.
RT-qPCR
used
to
measure
level
liver,
HepG2
cells
being
transfected
mimic
or
inhibitor;
In
rats
pretreated
TQ,
decreased
MMP9
VEGF,
increased
levels
detected.
Treating
led
upregulation
downregulation
showed
delay
wound
healing;
These
results
suggested
anti-angiogenic
TQ
may
be
regulation
miR-1-3p.
Phytomedicine Plus,
Journal Year:
2023,
Volume and Issue:
3(4), P. 100488 - 100488
Published: Sept. 27, 2023
:
The
human
body
is
regulated
by
the
controlled
production
and
secretion
of
thousands
chemicals,
including
polypeptides
called
cytokines.
Cytokines
play
crucial
roles
in
immune
system
reaction
following
tissue
injury
and/or
invasion
infectious
or
non-infectious
bodies.
They
are
classified
as
pro
anti-inflammatory
cytokines
depending
on
many
factors
such
structure
function.
Some
mediate
inflammatory
reactions
contribute
to
several
diseases,
Rheumatoid
arthritis.
Very
few
effective
treatment
strategies
exist
tackle
these
diseases
available
for
also
associated
with
severe
side
effects.
Although
we
scientific
innovations
medical
advancements
era,
natural
compounds
still
competing
modern
artificial
drugs
performing
well
effectively
treat
without
causing
main
purpose
this
review
discuss
effect
some
cytokine
elaborate
their
mode
action
further
based
already
recently
published
literature.
have
reviewed
a
selected
number
(Echinacea,
Curcumin,
Genistein,
Eugenol,
6-Gingerol,
Thymoquinone,
Allicin,
Quercetin,
Emodin
Parthenolide)
that
shown
pronounced
effects
physiological
conditions.
Immune
cells
produce
multiple
pro-inflammatory
could
be
accurately
using
can
block
intracellular
machinery
thus
reduce
secretion.
This
offers
an
intriguing
background
grasping
how
products
conduct
activity
at
cellular
level
sheds
light
other
examine
efficiency
same
aspect.
