Bisphenol A and human health: A review of the literature

Reproductive Toxicology, Journal Year: 2013, Volume and Issue: 42, P. 132 - 155

Published: Aug. 30, 2013

Language: Английский

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Human exposure to endocrine disrupting chemicals: effects on the male and female reproductive systems

Environmental Toxicology and Pharmacology, Journal Year: 2017, Volume and Issue: 51, P. 56 - 70

Published: March 7, 2017

Language: Английский

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Urinary Bisphenol A Levels in Young Men: Association with Reproductive Hormones and Semen Quality

Environmental Health Perspectives, Journal Year: 2014, Volume and Issue: 122(5), P. 478 - 484

Published: May 1, 2014

Background: Few human studies have examined bisphenol A (BPA) exposure in relation to semen quality and reproductive hormones men, results are divergent.Objectives: We associations between urinary BPA concentration hormones, as well quality, young men from the general population.Methods: Our study population consisted of 308 population. Urinary was measured by isotope dilution TurboFlow-liquid chromatography–tandem mass spectrometry. used multiple linear regression analysis estimate adjusting for confounding factors.Results: found that 98% had detectable levels BPA. Median (5th–95th percentiles) 3.25 ng/mL (0.59–14.89 ng/mL). Men with concentrations above lowest quartile higher serum testosterone, luteinizing hormone (LH), estradiol, free testosterone compared (ptrend ≤ 0.02). highest excretion on average 18% total (95% CI: 8, 28%), 22% LH 6, 39%), 13% estradiol 4, 24%) quartile. also significantly lower percentage progressive motile spermatozoa (–6.7 points, 95% –11.76, –1.63). not associated other parameters. Adjusting dietary patterns did influence results.Conclusions: The pattern could indicate an antiandrogenic or antiestrogenic effect, both, hypothalamic–pituitary–gonadal feedback system, possibly through a competitive inhibition at receptor level. However, additional research is needed confirm our findings further test suggested potential mechanisms.Citation: Lassen TH, Frederiksen H, Jensen TK, Petersen JH, Joensen UN, Main KM, Skakkebaek NE, Juul A, Jørgensen N, Andersson AM. 2014. men: association quality. Environ Health Perspect 122:478–484; http://dx.doi.org/10.1289/ehp.1307309

Language: Английский

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Reproductive endocrine-disrupting effects of triclosan: Population exposure, present evidence and potential mechanisms

Environmental Pollution, Journal Year: 2015, Volume and Issue: 206, P. 195 - 201

Published: July 13, 2015

Language: Английский

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The Impact of Bisphenol A on Fertility, Reproductive System, and Development: A Review of the Literature

International Journal of Endocrinology, Journal Year: 2019, Volume and Issue: 2019, P. 1 - 8

Published: April 10, 2019

Bisphenol A (BPA) has been used since the 1950s, in food packaging, industrial materials, dental sealants, and personal hygiene products. Everyone is exposed to BPA through skin, inhalation, digestive system. disrupts endocrine pathways, because it weak estrogenic, antiandrogenic, antithyroid activities. Despite rapid metabolism, can accumulate different tissues. Many researchers proved impact of on human development, finally reproductive There increasing evidence that fertility responsible for pathologies, e.g., testicular dysgenesis syndrome, cryptorchidism, cancers, decreased male follicle loss female.

Language: Английский

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Benzophenone-3: Comprehensive review of the toxicological and human evidence with meta-analysis of human biomonitoring studies

Environment International, Journal Year: 2023, Volume and Issue: 173, P. 107739 - 107739

Published: Jan. 6, 2023

Benzophenone-3 (BP-3) and its major metabolite benzophenone-1 (BP-1) are widely used as UV filters in sunscreens cosmetics to prevent sunburn skin damage, or stabilizers photodegradation many commercial products. As a result, their presence is ubiquitous the environment, wildlife humans. Based on endocrine disruption concerns, international regulatory agencies performing closer evaluation. This work aimed comprehensively review available human relevant evidence for safety issues MEDLINE/PubMed order create structured database of studies, well conduct an integrative analysis part Human Biomonitoring Europe (HBM4EU) Initiative. A total 1,635 titles abstracts were screened 254 references evaluated tabulated detail, classified different categories: i) exposure sources predictors; ii) biomonitoring (HBM) levels perform meta-analysis; iii) toxicokinetic data both experimental animals humans; iv) vitro vivo rodent toxicity studies; v) effect biomarkers health outcomes. Our showed that internal peak BP-3 concentrations achieved after single whole-body application commercially sunscreen (4% w/w) may overlap with eliciting disrupting effects vitro, causing adverse female reproductive rodents supported by still limited data. The included prolonged estrous cycle, altered uterine estrogen receptor gene expression, endometrium hyperplasia proliferation histology mammary gland, while indicated menstrual cycle hormonal alterations increased risk fibroids endometriosis. Among modes action reported (estrogenic, anti-androgenic, thyroid, etc.), especially BP-1 estrogenic activity at human-relevant concentrations, agreement observed endpoints. meta-analysis HBM studies identified higher concern North Americans, showing urinary average 10 20 times than European Asian populations, respectively. supports these benzophenones present properties, endorsing recent efforts limit exposure. reproducible comprehensive generated constitute point departure future assessments support initiatives. Meanwhile, individuals should not refrain from use. Commercially formulations using inorganic practically absorbed into systemic circulation be recommended susceptible populations.

Language: Английский

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Human Fetal Exposure to Triclosan and Triclocarban in an Urban Population from Brooklyn, New York

Environmental Science & Technology, Journal Year: 2014, Volume and Issue: 48(15), P. 8831 - 8838

Published: June 27, 2014

Triclosan (TCS) and triclocarban (TCC) are antimicrobial agents formulated in a wide variety of consumer products (including soaps, toothpaste, medical devices, plastics, fabrics) that regulated by the U.S. Food Drug Administration (FDA) Environmental Protection Agency. In late 2014, FDA will consider regulating use both chemicals, which under scrutiny regarding lack effectiveness, potential for endocrine disruption, contribution to bacterial resistance antibiotics. Here, we report on body burdens TCS TCC resulting from real-world exposures during pregnancy. Using liquid chromatography tandem mass spectrometry, determined concentrations TCS, TCC, its human metabolites (2'-hydroxy-TCC 3'-hydroxy-TCC) as well manufacturing byproduct (3'-chloro-TCC) total (Σ-) after conjugate hydrolysis maternal urine cord blood plasma cohort 181 expecting mother/infant pairs an urban multiethnic population Brooklyn, NY recruited 2007-09. was detected 100% 51% samples hydrolysis. The interquartile range (IQR) highly similar IQR reported previously age-matched National Health Nutrition Examination Survey (NHANES) 2003 2004, but typically higher than general (detection frequency = 74.6%). Urinary levels here first time pregnancy, showing median concentration 0.21 μg/L. correlated with phase-I metabolite ∑-2'-hydroxy-TCC (r 0.49) ∑-3'-chloro-TCC C 0.79), strongly ∑-3'-hydroxy-TCC 0.99). This biomonitoring study presents burden data occurring pregnancy provides additional composite exposure (i.e., consumer-product environmental sources) maternal-fetal unit United States.

Language: Английский

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Urinary bisphenol A concentrations are associated with reproductive parameters in young men

Environmental Research, Journal Year: 2017, Volume and Issue: 161, P. 122 - 128

Published: Nov. 21, 2017

Language: Английский

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Phthalate exposure and human semen quality: Results from an infertility clinic in China

Environmental Research, Journal Year: 2015, Volume and Issue: 142, P. 1 - 9

Published: June 15, 2015

Language: Английский

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Seminal and molecular evidence that sauna exposure affects human spermatogenesis

Human Reproduction, Journal Year: 2013, Volume and Issue: 28(4), P. 877 - 885

Published: Feb. 14, 2013

What are the effects of continuous sauna exposure on seminal parameters, sperm chromatin, apoptosis and expression genes involved in heat stress hypoxia?Scrotal hyperthermia by to can induce a significant alteration spermatogenesis.Several authors have evidenced that high temperature has dramatic spermatogenesis.A longitudinal time-course study. Data from 10 subjects exposed Finnish were collected before (T0), after 3 months sessions (T1) (T2) 6 (T3) end exposure.Ten normozoospermic volunteers underwent two per week for months, at 80-90°C, each lasting 15 min. Sex hormones, chromatin structure, hypoxia evaluated start, discontinuation. Student's t-test paired data was used statistical analysis.At exposure, we found strong impairment count motility (P < 0.001), while no change sex hormones present. Decreases percentage with normal histone-protamine substitution (78.7 ± 4.5 versus 69.0 4.1), condensation (70.7 4.7 63.6 3.3) mitochondrial function (76.8 4.9 54.0 6.1) also evident T1, parallel up-regulation response found. All these completely reversed T3.Absence abnormal parameters major limitation this study.Our demonstrated first time subjects, induces but reversible spermatogenesis, including DNA packaging. The large use Nordic countries its growing other parts world make it important consider impact lifestyle choice men's fertility.No external funding sought study conflict interest declare.

Language: Английский

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