Microorganisms,
Journal Year:
2024,
Volume and Issue:
12(9), P. 1920 - 1920
Published: Sept. 21, 2024
Antimicrobial
resistance
(AMR),
frequently
considered
a
major
global
public
health
threat,
requires
comprehensive
understanding
of
its
emergence,
mechanisms,
advances,
and
implications.
AMR’s
epidemiological
landscape
is
characterized
by
widespread
prevalence
constantly
evolving
patterns,
with
multidrug-resistant
organisms
(MDROs)
creating
new
challenges
every
day.
The
most
common
mechanisms
underlying
AMR
(i.e.,
genetic
mutations,
horizontal
gene
transfer,
selective
pressure)
contribute
to
the
emergence
dissemination
resistant
strains.
Therefore,
mitigation
strategies
(e.g.,
antibiotic
stewardship
programs—ASPs—and
infection
prevention
control
strategies—IPCs)
emphasize
importance
responsible
antimicrobial
use
surveillance.
A
One
Health
approach
interconnectedness
human,
animal,
environmental
health)
highlights
necessity
for
interdisciplinary
collaboration
holistic
in
combating
AMR.
Advancements
novel
therapeutics
alternative
agents
vaccines)
offer
promising
avenues
addressing
challenges.
Policy
interventions
at
international
national
levels
also
promote
ASPs
aiming
regulate
use.
Despite
all
observed
progress,
remains
pressing
concern,
demanding
sustained
efforts
address
emerging
threats
sustainability.
Future
research
must
prioritize
innovative
approaches
complex
socioecological
dynamics
This
manuscript
resource
researchers,
policymakers,
healthcare
professionals
seeking
navigate
develop
effective
mitigation.
