Brain and Behavior,
Journal Year:
2023,
Volume and Issue:
13(7)
Published: May 8, 2023
Introduction
Mesenteric
lymph
nodes
(MLNs)
are
central
in
immune
anatomy.
MLNs
associated
with
the
composition
of
gut
microbiota,
affecting
system
and
system.
Gut
microbiota
was
found
to
differ
among
individuals
different
social
hierarchies.
Nowadays,
excision
is
more
frequently
involved
gastrointestinal
surgery;
however,
potential
side
effects
on
dominance
still
unknown.
Methods
were
removed
from
male
mice
(7–8
weeks
old).
Four
after
MLN
removal,
test
performed
investigate
dominance;
hippocampal
serum
interleukin
(IL)‐1β,
IL‐10,
tumor
necrosis
factor‐alpha
(TNF‐α)
investigated;
histopathology
used
evaluate
local
inflammation
ileum.
The
then
examined
understand
possible
mechanism,
finally
intraperitoneal
injection
IL‐10
validate
effect
dominance.
Results
There
a
decrease
operation
group
compared
control
group,
as
well
levels,
but
no
difference
IL‐1β
TNF‐α
ileum
removal.
16S
rRNA
sequencing
analysis
showed
that
relative
abundance
class
Clostridia
decreased
group.
This
positively
levels.
Furthermore,
subset
increased
Conclusions
Our
findings
suggested
contributed
maintaining
dominance,
which
might
be
reduced
imbalance
specific
flora
microbiota.
Antibiotics,
Journal Year:
2022,
Volume and Issue:
11(6), P. 735 - 735
Published: May 30, 2022
Triclosan
(TCS),
a
broad-spectrum
antimicrobial
agent,
has
been
widely
used
in
personal
care
products,
medical
plastic
cutting
boards,
and
food
storage
containers.
Colgate
Total®
toothpaste,
containing
10
mM
TCS,
is
effective
controlling
biofilm
formation
maintaining
gingival
health.
Given
its
broad
usage,
TCS
present
ubiquitously
the
environment.
strong
lipophilicity
accumulation
ability
organisms,
it
potentially
harmful
to
biohealth.
Several
reports
suggest
toxicity
of
this
compound,
which
inserted
class
endocrine
disrupting
chemicals
(EDCs).
In
September
2016,
was
banned
by
U.S.
Food
Drug
Administration
(FDA)
European
Union
soap
products.
Despite
these
problems,
application
products
within
certain
limits
still
allowed.
Today,
unclear
whether
truly
toxic
mammals
adverse
effects
continuous,
long-term,
low
concentration
exposure
remain
unknown.
Indeed,
some
recent
use
as
repositioned
drug
for
cancer
treatment
cutaneous
leishmaniasis.
scenario
necessary
investigate
advantages
disadvantages
understand
advisable
or
not.
This
review
intends
highlight
pros
cons
that
are
associated
with
humans.
Military Medical Research,
Journal Year:
2023,
Volume and Issue:
10(1)
Published: Feb. 22, 2023
Abstract
Background
Triclosan
[5-chloro-2-(2,4-dichlorophenoxy)
phenol,
TCS],
a
common
antimicrobial
additive
in
many
personal
care
and
health
products,
is
frequently
detected
human
blood
urine.
Therefore,
it
has
been
considered
an
emerging
potentially
toxic
pollutant
recent
years.
Long-term
exposure
to
TCS
suggested
exert
endocrine
disruption
effects,
promote
liver
fibrogenesis
tumorigenesis.
This
study
was
aimed
at
clarifying
the
underlying
cellular
molecular
mechanisms
of
hepatotoxicity
effect
initiation
stage.
Methods
C57BL/6
mice
were
exposed
different
dosages
for
2
weeks
organ
toxicity
evaluated
by
various
measurements
including
complete
count,
histological
analysis
quantification.
Single
cell
RNA
sequencing
(scRNA-seq)
then
carried
out
on
TCS-
or
mock-treated
mouse
livers
delineate
TCS-induced
hepatotoxicity.
The
acquired
single-cell
transcriptomic
data
analyzed
from
aspects
differential
gene
expression,
transcription
factor
(TF)
regulatory
network,
pseudotime
trajectory,
communication,
systematically
dissect
events
after
exposure.
To
verify
fibrosis,
expression
levels
key
fibrogenic
proteins
examined
Western
blotting,
immunofluorescence,
Masson’s
trichrome
Sirius
red
staining.
In
addition,
normal
hepatocyte
MIHA
hepatic
stellate
LX-2
used
as
vitro
models
experimentally
validate
effects
immunological,
proteomic
metabolomic
technologies.
Results
We
established
relatively
short
term
murine
model
found
mainly
accumulated
liver.
scRNA-seq
performed
TCS-treated
control
group
profiled
expressions
>
76,000
cells
belonging
13
major
types.
Among
these
types,
hepatocytes
(HSCs)
significantly
increased
group.
that
promoted
fibrosis-associated
proliferation
hepatocytes,
which
Gata2
Mef2c
are
driving
TFs.
Our
also
induced
activation
HSCs,
verified
both
tissue
model.
other
changes
dysfunction
capillarization
endothelial
cells,
increase
fibrotic
characteristics
B
plasma
M2
phenotype-skewing
macrophage
deduced
analysis,
likely
contribute
progression
fibrosis.
Lastly,
ligand-receptor
pairs
involved
communications
identified
we
confirmed
role
GAS6_AXL
interaction-mediated
communication
promoting
Conclusions
modulates
activities
fates
several
specific
types
(including
Kupffer
capsular
macrophages)
liver,
regulates
interactions
between
thereby
leading
Overall,
provide
first
comprehensive
atlas
response
processes
Environmental Health Perspectives,
Journal Year:
2023,
Volume and Issue:
131(8)
Published: Aug. 1, 2023
Background:
Previous
studies
aiming
at
relating
exposure
to
phenols
and
phthalates
with
child
social
behavior
characterized
using
one
or
a
few
spot
urine
samples,
resulting
in
substantial
misclassification.
Moreover,
early
infancy
was
rarely
studied.
Objectives:
We
aimed
examine
the
associations
of
cohort
improved
assessment
priori
identify
chemicals
supported
by
higher
weight
evidence.
Methods:
Among
406
mother–child
pairs
from
French
Assessment
Air
Pollution
during
Pregnancy
Effect
on
Health
(SEPAGES)
cohort,
25
phenols/phthalate
metabolites
were
measured
within-subject
pools
repeated
samples
collected
second
third
pregnancy
trimesters
(∼21
samples/trimester)
2
months
1-year
age
(∼7
samples/period).
Social
parent-reported
3
years
Responsiveness
Scale
(SRS).
A
structured
literature
review
animal
human
evidence
performed
prioritize
phthalates/phenols
based
their
likelihood
affect
behavior.
Both
adjusted
linear
regression
Bayesian
Weighted
Quantile
Sum
(BWQS)
models
fitted.
False
discovery
rate
(FDR)
correction
applied
only
nonprioritized
chemicals.
Results:
Prioritized
compounds
included
bisphenol
A,
S,
triclosan
(TCS),
diethyl-hexyl
phthalate
(ΣDEHP),
mono-ethyl
(MEP),
mono-n-butyl
(MnBP),
mono-benzyl
(MBzP).
With
exception
bisphenols,
which
showed
mixed
pattern
positive
negative
pregnant
mothers
neonates,
prenatal
observed.
Most
observed
prioritized
1-y-old
infants:
Each
doubling
urinary
TCS
(β=0.78;
95%
CI:
0.00,
1.55)
MEP
(β=0.92;
−0.11,
1.96)
concentrations
associated
worse
total
SRS
scores,
whereas
MnBP
ΣDEHP
Awareness
(β=0.25;
0.01,
0.50)
Communication
(β=0.43;
−0.02,
0.89)
respectively.
BWQS
also
suggested
[Beta
1=1.38;
credible
interval
(CrI):
−0.18,
2.97],
(Beta
1=0.37;
CrI:
0.06,
0.70),
1=0.91;
0.31,
1.53)
scores
per
quartile
increase
mixture
assessed
infants.
The
did
not
remain
after
FDR
correction,
benzophenone-3
infants,
suggestively
(corrected
p=0.07).
Discussion:
search
allowed
us
adapt
our
statistical
analysis
according
create
corpus
experimental
epidemiological
knowledge
better
interpret
findings.
Early
appears
be
sensitive
window
that
should
further
investigated.
https://doi.org/10.1289/EHP11798
Journal of Agricultural and Food Chemistry,
Journal Year:
2023,
Volume and Issue:
71(20), P. 7866 - 7877
Published: May 16, 2023
Perfluorooctane
sulfonate
(PFOS),
a
new
type
of
persistent
organic
pollutant
in
the
environment
water,
has
drawn
significant
attention
recent
years
due
to
its
widespread
prevalence
and
high
toxicity.
Neurotoxicity
is
regarded
as
one
major
toxic
effects
PFOS,
while
research
studies
on
PFOS-induced
depression
underlying
mechanisms
remain
scarce.
In
this
study,
behavioral
tests
revealed
depressive-like
behaviors
PFOS-exposed
male
mice.
Neuron
damages
including
pyknosis
staining
deepening
were
identified
through
hematoxylin
eosin
staining.
Then,
we
noticed
elevation
glutamate
proline
levels
well
decline
glutamine
tryptophan
levels.
Proteomics
analysis
105
differentially
expressed
proteins
that
change
dose-dependent
manner
PFOS
exposure
activated
glutamatergic
synapse
signaling
pathway,
which
further
confirmed
by
Western
blot,
data
consistent
with
findings
proteomics
analysis.
Additionally,
downstream
cyclic
AMP-responsive
element-binding
protein
(CREB)/brain-derived
neurotrophic
factor
(BDNF)
synaptic
plasticity-related
postsynaptic
density
95,
synaptophysin,
downregulated.
Our
results
highlight
may
inhibit
plasticity
hippocampus
via
CREB/BDNF
pathway
cause
