Understanding the bidirectional interactions between two-dimensional materials, microorganisms, and the immune system

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 188, P. 114422 - 114422

Published: July 8, 2022

Two-dimensional (2D) materials such as the graphene-based materials, transition metal dichalcogenides, carbides and nitrides (MXenes), black phosphorus, hexagonal boron nitride, others have attracted considerable attention due to their unique physicochemical properties. This is true not least in field of medicine. Understanding interactions between 2D immune system therefore paramount importance. Furthermore, emerging evidence suggests that may interact with microorganisms - pathogens well commensal bacteria dwell on our body. We discuss interplay system, microbial world order bring a systems perspective bear biological materials. The use vectors for drug delivery adjuvants tumor vaccines, counteract inflammation promote tissue regeneration, are explored. bio-corona formation biodegradation reciprocal microorganisms, also highlighted. Finally, we consider future challenges pertaining biomedical applications various classes

Language: Английский

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Disturbing ion regulation and excretion in medaka (Oryzias melastigma) gills by microplastics: Insights from the gut-gill axis

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 857, P. 159353 - 159353

Published: Oct. 15, 2022

Language: Английский

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Polystyrene nanoparticles enhance the adverse effects of di-(2-ethylhexyl) phthalate on male reproductive system in mice

Ecotoxicology and Environmental Safety, Journal Year: 2022, Volume and Issue: 245, P. 114104 - 114104

Published: Sept. 26, 2022

Coexposure of nanoplastics (NPs) with other pollutants adsorbed from the surroundings has received extensive attention. Currently, combined effects NPs and plasticizers remain unclear. Di-(2-ethylhexyl) phthalate (DEHP) is a commonly used plasticizer that raised much concern owing to its ubiquitous pollution endocrine-disrupting potential. This study aimed investigate toxic on male reproductive system upon coexposure DEHP. The C57BL/6J mice were orally administrated polystyrene nanoparticles (PSNPs), DEHP or both for 35 days evaluate their sperm quality, histology testes epididymides, testicular transcriptomic characteristics as well expression some important genes in epididymides. low-dose PSNPs here did not induce significant changes while alone cotreatment caused notable impairment, mainly manifesting decreased quality aberrant structure testis epididymis. Moreover, enhanced found group when compared individual treatment group, manifested by more obvious alterations parameters histological Testicular analysis revealed differential regulation involved immune response, cytoplasmic pattern recognition receptor signaling pathways, protein ubiquitination, oxidative stress, necrotic cell death, ATP synthesis cellular respiratory chain. RT-qPCR verified patterns Cenpb, Crisp1 Mars changed testes, relevant epididymal function including Aqp9 Octn2 downregulated particularly group. Collectively, our results emphasize at an environmentally dose can toxicity, may aggravate effects.

Language: Английский

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The importance of multi-omics approaches for the health assessment of freshwater ecosystems

Molecular & Cellular Toxicology, Journal Year: 2022, Volume and Issue: 19(1), P. 3 - 11

Published: Sept. 6, 2022

Language: Английский

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Multiomics analysis reveals the molecular basis for increased body weight in silkworms (Bombyx mori) exposed to environmental concentrations of polystyrene micro- and nanoplastics

Journal of Advanced Research, Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 1, 2023

Micro- and nanoplastics (MNPs) are emerging environmental pollutants that have raised serious concerns about their potential impact on ecosystem organism health. Despite increasing efforts to investigate the impacts of micro- biota little is known terrestrial organisms, especially insects, at concentrations. To address this gap, we used an insect model, silkworm Bombyx mori examine long-term different sizes polystyrene (PS) MNPs environmentally realistic concentrations (0.25 1.0 μg/mL). After exposure PS-MNPs over most larval lifetime (from second last instar), endpoints were examined by integrated physiological (growth survival) multiomics approach (metabolomics, 16S rRNA, transcriptomics). Our results indicated dietary exposures had no lethal effect survivorship, but interestingly, increased host body weight. Multiomics analysis revealed significantly altered multiple pathways, particularly lipid metabolism, leading enriched energy reserves. Furthermore, changed structure composition gut microbiome abundance bacteria Acinetobacter Enterococcus. Notably, predicted functional profiles metabolite expressions correlated with bacterial abundance. Importantly, these observed effects particle size-dependent ranked as PS-S (91.92 nm) > PS-M (5.69 µm) PS-L (9.7 µm). Overall, exerted stimulatory metabolism subsequently enhanced weight in silkworms, suggesting chronic might trigger gain animals humans influencing microbiota homeostasis.

Language: Английский

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Unraveling the threat: Microplastics and nano-plastics' impact on reproductive viability across ecosystems

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 913, P. 169525 - 169525

Published: Dec. 22, 2023

Language: Английский

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Size-dependent effects of polystyrene microplastics on gut metagenome and antibiotic resistance in C57BL/6 mice

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 254, P. 114737 - 114737

Published: March 10, 2023

Microplastic pollution is an emerging threat for marine and terrestrial ecosystems, which has raised global concerns about its implications human health. Mounting evidence shown that the gut microbiota plays a key role in health diseases. The bacteria could be disturbed by many environmental factors, including microplastic particles. However, size effect of polystyrene microplastics on mycobiome, as well functional metagenome not been studied. In this study, we performed ITS sequencing to explore fungal composition, combination with shotgun metagenomics reveal effects metagenome. We found particles 0.05-0.1 µm diameter showed greater impact bacterial composition metabolic pathways than 9-10 diameter. Our results suggested size-depended should ignored risk assessment microplastics.

Language: Английский

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The measurement of food safety and security risks associated with micro- and nanoplastic pollution

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 161, P. 116993 - 116993

Published: Feb. 24, 2023

Agricultural systems are increasingly impacted by micro- and nanoplastic (MNP) pollution raising concerns for food safety security. To understand the scale of problem develop mitigation strategies, there is a need to characterise effects impacts MNP. Here, we discuss main MNP entry pathways into human chain their effects/impact on feed sources, identifying major research gaps hindering robust risk assessments pollution. We identified emerging current analytical methods facilitate closing those gaps. An interdisciplinary approach combining omics strategies with novel fast reliable measurement plastic additive leaching characterisation across multiple dynamic environments can accurately quantify risks. Data this type essential support policy development legislation prevent further from causing security problems worldwide.

Language: Английский

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Microplastics separation using stainless steel mini-hydrocyclones fabricated with additive manufacturing

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 840, P. 156697 - 156697

Published: June 14, 2022

Language: Английский

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Zebrafish: A trending model for gut-brain axis investigation

Aquatic Toxicology, Journal Year: 2024, Volume and Issue: 270, P. 106902 - 106902

Published: March 17, 2024

Language: Английский

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