Microplastics and nanoplastics induced differential respiratory damages in tilapia fish Oreochromis niloticus

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 465, P. 133181 - 133181

Published: Dec. 6, 2023

Language: Английский

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Environmental toxicology of marine microplastic pollution

Cambridge Prisms Plastics, Journal Year: 2023, Volume and Issue: 1

Published: Jan. 1, 2023

Abstract Over the past decade, there have been increasing recognition and concern of toxicological impacts microplastics (MPs) in environment, which widely found various marine environments from estuary to deep oceans. Numerous studies conducted on MPs organisms, especially phytoplankton, zooplankton, bivalves, fish different trophic levels. These mainly focused measurements bioaccumulation their resulting biological at molecular, metabolic, biochemical, physiological, organismic This review examines over recent years toxicology particularly toxicity MPs. The organisms are diverse, complexity organism physiology as well physical chemical properties need be considered. Future should consider environmental relevance research development quantitative tools model transport, bioaccumulation, important for real risk assessments environments.

Language: Английский

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Near-Infrared-II In Vivo Visualization and Quantitative Tracking of Micro/Nanoplastics in Fish

ACS Nano, Journal Year: 2023, Volume and Issue: 17(19), P. 19410 - 19420

Published: Oct. 2, 2023

As emerging contaminants, micro/nanoplastics (MNPs) are widely present in aquatic environments and often ingested by organisms. However, the vivo trafficking fate of MNPs remain largely unknown. Here, we developed near-infrared (NIR) aggregated-induced emission (AIE) fluorophore-labeled microplastics (2 μm) nanoplastics (100 nm) as models MNPs. This model was based on NIR-AIE technique with strong at second (NIR-IIII) window, which overcomes interference autofluorescence observation artifacts detection commercial fluorescent-labeled particles. Due to its deep tissue penetration noninvasiveness, dynamic process accumulation transport individuals can be tracked NIR imaging. We then directly visualized quantified uptake depuration processes MPs NPs zebrafish. The results showed that were mainly accumulated fish gut, distribution heterogeneous. tended accumulate more fore mid areas gut compared NPs. Besides, both could large quantities locally might cause intestinal obstruction. slowly during initial exposure followed rapid sustained gut. Based these kinetic depuration, a refined toxicokinetic (TK) describe changes Overall, this study proposed MNP technique, provided reliable tracer technology for visualization, tracking quantification vivo.

Language: Английский

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Single-Cell RNA Sequencing Profiling Cellular Heterogeneity and Specific Responses of Fish Gills to Microplastics and Nanoplastics

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(13), P. 5974 - 5986

Published: March 21, 2024

Fish gills are highly sensitive organs for microplastic (MP) and nanoplastic (NP) invasions, but the cellular heterogeneity of fish to MPs NPs remains largely unknown. We employed single-cell RNA sequencing investigate responses individual cell populations in tilapia Oreochromis niloticus MP NP exposure at an environmentally relevant concentration. Based on detected differentially expressed gene (DEG) numbers, most affected immune cells by were macrophages, while stimulus primarily targeted T cells. In response NPs, H+-ATPase-rich exhibited distinct changes as compared with Na+/K+-ATPase-rich pavement Fibroblasts identified a potential cell-type biomarker interaction O. gills, evidenced reduced counts mostly DEGs among 12 populations. The MP-sensitive fibroblast subpopulation was lipofibroblasts. Cell–cell communications between fibroblasts cells, neurons, neuroepithelial significantly inhibited exposure. Collectively, our study demonstrated provided markers their toxicological mechanisms resolution.

Language: Английский

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The effects of microplastics on ionoregulatory processes in the gills of freshwater fish and invertebrates: A prospective review

Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology, Journal Year: 2024, Volume and Issue: 295, P. 111669 - 111669

Published: May 26, 2024

From review of the very few topical studies to date, we conclude that while effects are variable, microplastics can induce direct ionoregulatory disturbances in freshwater fish and invertebrates. However, intensity depends on microplastic type, size, concentration, exposure regime. More numerous where indirect inferences about possible be drawn; these indicate increased mucus production, altered breathing, histopathological gill structure, oxidative stress, alterations molecular pathways. All could have negative homeostasis. previous research has suffered from a lack standardized reporting characteristics conditions. Often overlooked is fact dynamic contaminants, changing over time through degradation fragmentation subsequently exhibiting surface chemistry, notably an presence diversity functional groups. The same groups characterized also present dissolved organic matter, often termed carbon (DOC), class substances for which far greater understanding their actions. We highlight instances resemble those DOC exposure. propose future investigations, vivo techniques proven useful should used including measurements transepithelial potential, net unidirectional radio-isotopic ion flux rates, concentration kinetic analyses uptake transport. sophisticated vitro approaches using cultured epithelia, Ussing chamber experiments surrogate membranes, scanning selective electrode (SIET) may prove useful. Finally, advocate minimum requirements properties experimental conditions help advance this important emerging field.

Language: Английский

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Fish Physiologically Based Toxicokinetic Modeling Approach for In Vitro–In Vivo and Cross-Species Extrapolation of Endocrine-Disrupting Chemicals in Risk Assessment

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(8), P. 3677 - 3689

Published: Feb. 14, 2024

High-throughput in vitro assays combined with vitro–in vivo extrapolation (IVIVE) leverage responses to predict the corresponding exposures and thresholds of concern. The integrated approach is also expected offer potential for efficient tools provide estimates chemical toxicity various wildlife species instead animal testing. However, developing fish physiologically based toxicokinetic (PBTK) models IVIVE ecological applications challenging, especially plausible estimation an internal effective dose, such as equivalent concentration (FEC). Here, a PBTK model linked was established, parameter optimization unbound fraction, pH-dependent ionization hepatic clearance, integration temperature effect growth dilution. PBTK–IVIVE provides not only more precise tissue-specific concentrations but reasonable approximation FEC targeting estrogenic potency endocrine-disrupting chemicals. Both predictions were compared data accurate most indissociable/dissociable Furthermore, can help determine cross-species variability sensitivity among five species. Using available IVIVE-derived target pathways helpful develop predicted no-effect chemicals similar mode action support screening-level risk assessment.

Language: Английский

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First report on the toxicity of SARS-CoV-2, alone and in combination with polyethylene microplastics in neotropical fish

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 882, P. 163617 - 163617

Published: April 22, 2023

Language: Английский

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Impacts of Nile Tilapia (Oreochromis niloticus) exposed to microplastics in bioflocs system

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 901, P. 165921 - 165921

Published: July 30, 2023

Language: Английский

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Norfloxacin affects inorganic nitrogen compound transformation in tailwater containing Corbicula fluminea

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 476, P. 135116 - 135116

Published: July 6, 2024

Language: Английский

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In Vivo Visualization of Microplastic Degradability and Intestinal Functional Responses in a Plastivore Insect

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 486, P. 137109 - 137109

Published: Jan. 5, 2025

Language: Английский

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