A review of recent studies on toxicity, sequestration, and degradation of per- and polyfluoroalkyl substances (PFAS)

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 436, P. 129120 - 129120

Published: May 11, 2022

The fate, effects, and treatment of per- polyfluoroalkyl substances (PFAS), an anthropogenic class chemicals used in industrial commercial production, are topics great interest recent research news cycles. This stems from the ubiquity PFAS global environment as well their significant toxicological effects humans wildlife. Research on toxicity, sequestration, removal, degradation has grown rapidly, leading to a flood valuable knowledge that can get swamped out perpetual rise number publications. Selected papers Journal Hazardous Materials between January 2018 May 2022 reviewed this article made available open-access publications for one year, order facilitate distribution critical surrounding PFAS. review discusses routes toxicity observed mammalian cellular models, human health exposed communities. Studies evaluate through in-silico approaches highlighted paper. Removal modified carbon sorbents, nanoparticles, anion exchange materials discussed while comparing efficiencies different classes Finally, various biotic abiotic techniques, pathways mechanisms involved provide better understanding removal cost effectiveness existing strategies.

Language: Английский

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The uses of zebrafish (Danio rerio) as an in vivo model for toxicological studies: A review based on bibliometrics

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 272, P. 116023 - 116023

Published: Jan. 30, 2024

An in vivo model is necessary for toxicology. This review analyzed the uses of zebrafish (Danio rerio) toxicology based on bibliometrics. Totally 56,816 publications about from 2002 to 2023 were found Web Science Core Collection, with Toxicology as top 6 among all disciplines. Accordingly, bibliometric map reveals that "toxicity" has become a hot keyword. It further most common exposure types include acute, chronic, and combined exposure. The toxicological effects behavioral, intestinal, cardiovascular, hepatic, endocrine toxicity, neurotoxicity, immunotoxicity, genotoxicity, reproductive transgenerational toxicity. mechanisms oxidative stress, inflammation, autophagy, dysbiosis gut microbiota. toxicants commonly evaluated by using nanomaterials, arsenic, metals, bisphenol, dioxin. Overall, provide unique well-accepted investigate mechanisms. We also discussed possible ways address some limitations model, such combination human organoids avoid species differences.

Language: Английский

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Adverse Effects of Perfluorooctane Sulfonate on the Liver and Relevant Mechanisms

Toxics, Journal Year: 2022, Volume and Issue: 10(5), P. 265 - 265

Published: May 19, 2022

Perfluorooctane sulfonate (PFOS) is a persistent, widely present organic pollutant. PFOS can enter the human body through drinking water, ingestion of food, contact with utensils containing PFOS, and occupational exposure to have adverse effects on health. Increasing research shows that liver major target damage tissue disrupt its function; however, exact mechanisms remain unclear. In this study, we reviewed cells, as well function, provide reference for subsequent studies related toxicity injury caused by PFOS.

Language: Английский

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Poly- and Perfluoroalkyl Substances Induce Immunotoxicity via the TLR Pathway in Zebrafish: Links to Carbon Chain Length

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(15), P. 6139 - 6149

Published: April 5, 2023

Previous studies have reported the immunotoxicity of per- and polyfluoroalkyl substances (PFASs), but it remains a significant challenge to assess over 10,000 distinct PFASs registered in distributed structure-searchable toxicity (DSSTox) database. We aim reveal mechanisms different hypothesize that PFAS is dependent on carbon chain length. Perfluorobutanesulfonic acid (PFBA), perfluorooctanoic (PFOA), perfluorononanoic (PFNA) representing lengths (4-9) at environmentally relevant levels strongly reduced host's antibacterial ability during zebrafish's early-life stage. Innate adaptive immunities were both suppressed after exposures, exhibiting induction macrophages neutrophils expression immune-related genes indicators. Interestingly, PFAS-induced immunotoxic responses positively correlated Moreover, activated downstream toll-like receptor (TLR), uncovering seminal role TLR immunomodulatory effects. Myeloid differentiation factor 88 (MyD88) morpholino knock-down experiments MyD88 inhibitors alleviated PFASs. Overall, comparative results demonstrate differences due length zebrafish, providing new insights into prediction classification mode toxic action based

Language: Английский

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Cannabidiol alleviates perfluorooctane sulfonate-induced macrophage extracellular trap mediate inflammation and fibrosis in mice liver

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 263, P. 115374 - 115374

Published: Aug. 14, 2023

As a new type of persistent organic pollutant, perfluorooctane sulphonate (PFOS) has received extensive attention worldwide. Cannabidiol (CBD) is non-psychoactive natural cannabinoid extract that been proved to have antioxidation, regulation inflammation and other functions. However, the effects PFOS on liver injury whether CBD can alleviate PFOS-induced are still unclear. Therefore, in this study, we used (10 mg/kg) and/or (5 intraperitoneally inject mice for 30 days. We found exposure led inflammatory infiltration mice, increased formation macrophage extracellular trap (MET), promoted fibrosis. In vitro, established coculture system RAW264.7, AML12 LX-2 cells, treated them with μM) (200 μM). The results showed could also induce expression MET, fibrosis marker genes vitro. Coiled-coil domain containing protein 25 (CCD25), as MET-DNA sensor, was investigate its ability regulate fibrosis, knocked down CCDC25 downstream proteins (integrin-linked kinase, ILK) by siRNA technology, QNZ inhibit NF-κB pathway. knockdown ILK inhibition pathway MET-induced gene expression. summary, MET promote through CCDC25-ILK-NF-κB signaling axis, while treatment protective effect, it Macromolecular docking effect achieved combining peptidylarginine deiminase 4 (PAD4) release MET. regulating axis an innovative option effectively reduce hepatotoxicity. Our study reveals mechanism hepatotoxicity provides promising insights into role process.

Language: Английский

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Interactive effects of polystyrene nanoplastics and 6:2 chlorinated polyfluorinated ether sulfonates on the histomorphology, oxidative stress and gut microbiota in Hainan Medaka (Oryzias curvinotus)

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 880, P. 163307 - 163307

Published: April 6, 2023

Language: Английский

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Review of the zebrafish as a model to investigate per- and polyfluoroalkyl substance toxicity

Toxicological Sciences, Journal Year: 2023, Volume and Issue: 194(2), P. 138 - 152

Published: May 23, 2023

Abstract The existence of thousands per- and polyfluoroalkyl substances (PFAS) evidence that some cause adverse health effects has created immense need to better understand PFAS toxicity move beyond one-chemical-at-a-time approaches hazard assessment for this chemical class. zebrafish model enables rapid large libraries PFAS, powerful comparison compounds in a single vivo system, evaluation across life stages generations, led significant advances research recent years. focus review is assess contemporary findings regarding toxicokinetics, apical outcomes, potential modes action using the model. Much peer-reviewed literature focused on small subset structural subclasses, such as perfluoroalkyl sulfonic acids carboxylic acids. However, data more diverse structures are enabling prioritization concern. Structure-activity comparisons utilization modeling ‘omics technologies have greatly contributed our understanding growing number will surely inform predictive capabilities many future.

Language: Английский

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Assessing the hepatotoxicity of phosphogypsum leachate in zebrafish (Danio rerio)

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 926, P. 172018 - 172018

Published: March 27, 2024

Language: Английский

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Forever Chemicals, Per-and Polyfluoroalkyl Substances (PFAS), in Lubrication

Lubricants, Journal Year: 2024, Volume and Issue: 12(4), P. 114 - 114

Published: March 29, 2024

Per- and polyfluoroalkyl substances (PFAS), also known as forever chemicals, exhibit exceptional chemical stability resistance to environmental degradation thanks their strong C-F bonds nonpolar nature. However, widespread use persistence have a devastating impact on the environment. This review examines roles of PFAS in tribological applications, specifically lubricants lubricating systems. article focuses conventional advanced lubricants, including ionic liquids (ILs) modern automotive vehicles. The objective this paper is provide comprehensive overview adverse impacts whilst acknowledging outstanding performance surface coatings, composite materials, additives oils greases. pathways through which are introduced into environment via systems such seals O-rings identified, alongside subsequent dispersion routes interfaces across they interact. Furthermore, we examine toxicological implications exposure terrestrial aquatic life forms, plants, animals, humans, along with ecological consequences bioaccumulation biomagnification trophic levels ecosystems. ends potential remediation strategies for use, treatment technologies, biodegradation, recovery recycling methods, search more environmentally benign alternatives.

Language: Английский

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Evidence of promoting effects of 6:2 Cl-PFESA on hepatocellular carcinoma proliferation in humans: An ideal alternative for PFOS in terms of environmental health?

Environment International, Journal Year: 2024, Volume and Issue: 186, P. 108582 - 108582

Published: March 16, 2024

Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are synthetic chemicals, encompassing compounds like perfluorooctane sulfonate (PFOS), which have widespread applications across various industries, including food packaging firefighting. In recent years, China has increasingly employed 6:2 Cl-PFESA as an alternative to PFOS. Although the association between PFAS exposure hepatocellular carcinoma (HCC) been demonstrated, underlying mechanisms that promote HCC proliferation uncleared. Therefore, we aimed investigate effects differences of PFOS on through in vivo vitro tumor models. Our results reveal both significantly contribute vivo. Exposure led reduced population doubling times, enlarged cell colony sizes, enhanced DNA synthesis efficiency, a higher proportion cells undergoing mitosis. Furthermore, Cl-PFES) shown activate PI3K/AKT/mTOR signaling pathway inhibit necroptosis. This action consequently enhances cells. phenotypic assay findings suggest tumorigenic potential surpasses PFOS; subcutaneous model using nude mice, mean weight for Cl-PFESA-treated cohort was 2.33 times observed (p < 0.01). Despite being considered safer substitute PFOS, pronounced this chemical growth warrant thorough assessment hepatotoxicity risks linked its usage.

Language: Английский

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