Efficient photodegradation of perfluoroalkyl substances under visible light by hexagonal ZnIn2S4 nanosheets

Journal of Environmental Sciences, Journal Year: 2024, Volume and Issue: 148, P. 116 - 125

Published: Jan. 17, 2024

Language: Английский

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Hepatic injury and ileitis associated with gut microbiota dysbiosis in mice upon F–53B exposure

Environmental Research, Journal Year: 2024, Volume and Issue: 248, P. 118305 - 118305

Published: Feb. 1, 2024

Language: Английский

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Associations of per- and polyfluoroalkyl substances (PFAS) and their mixture with risk of rheumatoid arthritis in the U.S. adult population

Environmental Health, Journal Year: 2024, Volume and Issue: 23(1)

Published: April 13, 2024

Abstract Background Per- and polyfluoroalkyl substances (PFAS) are known environmental contaminants with immunosuppressive properties. Their connection to rheumatoid arthritis (RA), a condition influenced by the immune system, is not well studied. This research explores association between PFAS exposure RA prevalence. Methods utilized data from NHANES, encompassing sample of 10,496 adults 2003–2018 cycles, focusing on serum levels several PFAS. The presence was determined based self-reports. study used multivariable logistic regression assess relationship individual risk, adjusting for covariates calculate odds ratios (ORs). combined effects mixtures were evaluated using BKMR, WQS regression, quantile g-computation. Additionally, sex-specific associations explored through stratified analysis. Results Higher PFOA (OR = 0.88, 95% CI: 0.79, 0.98), PFHxS 0.91, 0.83, 1.00), PFNA 0.87, 0.77, PFDA 0.89, 0.81, 0.99) concentration related lower RA. Sex-specific analysis in single chemical models indicated significant inverse only evident females. BKMR did show an obvious pattern estimates across mixture. outcomes sex-stratified g-computation demonstrated that increase mixture associated decreased females (OR: 0.76, 0.62, 0.92). We identified interaction term WQS*sex 100 repeated hold out Notably, higher significantly reduced (mean OR 0.93, 0.98). Conclusions indicates potential various their observed relationships statistically but males. These findings contribute growing body evidence indicating may have effects.

Language: Английский

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Electrochemical-based approaches for the treatment of forever chemicals: Removal of perfluoroalkyl and polyfluoroalkyl substances (PFAS) from wastewater

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 861, P. 160440 - 160440

Published: Nov. 25, 2022

Language: Английский

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Per- and polyfluoroalkyl substances exposure and its influence on the intestinal barrier: An overview on the advances

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 852, P. 158362 - 158362

Published: Aug. 30, 2022

Language: Английский

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Association between a Mixture of Per- and Polyfluoroalkyl Substances (PFAS) and Inflammatory Biomarkers in the Atlanta African American Maternal–Child Cohort

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(36), P. 13419 - 13428

Published: Aug. 31, 2023

Per- and polyfluoroalkyl substances (PFAS) have been identified as environmental contributors to adverse birth outcomes. One potential mechanistic pathway could be through PFAS-related inflammation cytokine production. Here, we examined associations between a PFAS mixture inflammatory biomarkers during early late pregnancy from participants enrolled in the Atlanta African American Maternal–Child Cohort (N = 425). Serum concentrations of multiple were detected >90% samples at 8–14 weeks gestation. interferon-γ (IFN-γ), interleukin 6 (IL-6), 10 (IL-10), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP) measured up two time points (8–14 24–30 gestation). The effect on each biomarker was using quantile g-computation, Bayesian kernel machine regression (BKMR), Weighted Sums (BWS), weighted sum (WQS) regression. Across all models, associated with increased IFN-γ, IL-10, TNF-α both points, strongest effects being observed weeks. Using increasing 29% (95% confidence interval 18.0%, 40.7%) increase Similarly, BWS, (summed 0.29, 95% highest posterior density 0.17, 0.41). also positively BKMR [75th vs 50th percentile: 17.1% credible 7.7%, 27.4%)]. Meanwhile, PFOS consistently main drivers overall across four methods. Our findings indicated an prenatal exposure is pro-inflammatory cytokines, potentially contributing

Language: Английский

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Combined exposure with microplastics increases the toxic effects of PFOS and its alternative F-53B in adult zebrafish

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 920, P. 170948 - 170948

Published: Feb. 15, 2024

Language: Английский

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Chlorinated Polyfluoroalkyl Ether Sulfonic Acids (Cl-PFESAs) Are Associated with Eye Diseases in Humans and Eye Toxicity in Zebrafish

Environment & Health, Journal Year: 2024, Volume and Issue: 2(6), P. 390 - 400

Published: March 28, 2024

Evidence from animal experiments has shown that chlorinated polyfluoroalkyl ether sulfonic acids (Cl-PFESAs) can induce vision dysfunction in zebrafish. However, environmental epidemiological evidence supporting this hypothesis remains limited. In our case–control study, samples collected 270 individuals (135 controls and 135 cases) the Isomers of C8 Health Project data were analyzed for Cl-PFESAs. We also repeated analysis on zebrafish to support findings humans decipher mechanism underlying Cl-PFESA eye toxicity. The serum levels per- substances (PFASs) alternatives significantly higher cases than controls. Higher associated with greater odds diseases, trend showed a statistically significant dose-dependent relationship. Shapley additive explanations (SHAP) value indicated 8:2 was dominant disease risk factor among 13 studied PFASs. experiments, Cl-PFESAs induced toxicity adult by oxidative damage cell apoptosis. Compared control group, there reduced thicknesses inner plexiform layer (IPL), outer (OPL), retinal tissue exposed Our study provides human clinical experimental data, showing exposure PFASs increases development

Language: Английский

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Prenatal PFAS exposure, gut microbiota dysbiosis, and neurobehavioral development in childhood

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 469, P. 133920 - 133920

Published: March 3, 2024

Language: Английский

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Integrated physiological, intestinal microbiota, and metabolomic responses of adult zebrafish (Danio rerio) to subacute exposure to antimony at environmentally relevant concentrations

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 277, P. 116326 - 116326

Published: April 18, 2024

The available information regarding the impact of antimony (Sb), a novel environmental pollutant, on intestinal microbiota and host health is limited. In this study, we conducted physiological characterizations to investigate response adult zebrafish different concentrations (0, 30, 300, 3000 µg/L) Sb over period 14 days. Biochemical pathological changes demonstrated that effectively compromised integrity physical barrier induced inflammatory responses as well oxidative stress. Analysis both microbial community metabolome revealed exposure 0 30 µg/L resulted in similar structures; however, 300 altered communities' composition (e.g., decline genus Cetobacterium an increase Vibrio). Furthermore, significantly decreased levels bile acids glycerophospholipids while triggering inflammation but activating self-protective mechanisms such antibiotic presence. Notably, even can trigger dysbiosis metabolites, potentially impacting fish through "microbiota-intestine-brain axis" contributing disease initiation. This study provides valuable insights into toxicity-related concerning impacts aquatic organisms with significant implications for developing management strategies.

Language: Английский

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