Cylindrospermopsin enhances the conjugative transfer of plasmid-mediated multi-antibiotic resistance genes through glutathione biosynthesis inhibition DOI Creative Commons
Shuran Yang,

Jinrui Cao,

Zhao Chen

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 276, P. 116288 - 116288

Published: April 5, 2024

Cylindrospermopsin (CYN), a cyanobacterial toxin, has been detected in the global water environment. However, information concerning potential environmental risk of CYN is limited, since majority previous studies have mainly focused on adverse health effects through contaminated drinking water. The present study reported that at environmentally relevant levels (0.1-100 μg/L) can significantly enhance conjugative transfer RP4 plasmid Escherichia coli genera, wherein application 10 μg/L led to maximum fold change ∼6.5- 16 h exposure. Meanwhile, evaluation underlying mechanisms revealed concentration exposure could increase oxidative stress bacterial cells, resulting ROS overproduction. In turn, this an upregulation antioxidant enzyme-related genes avoid attack. Further, inhibition synthesis glutathione (GSH) was also detected, which rapid depletion GSH cells and thus triggered SOS response promoted process. Increase cell membrane permeability, expression related pilus generation, ATP synthesis, gene were observed. These results highlight impact spread antimicrobial resistance environments.

Language: Английский

Integrated transcriptomic and metabolomic analysis of the hepatotoxicity of dichloroacetonitrile DOI
Jinfeng He, Hongyan Liu,

Zemeng Li

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 927, P. 172237 - 172237

Published: April 4, 2024

Language: Английский

Citations

2
Tebuconazole promotes spread of a multidrug-resistant plasmid into soil bacteria to form new resistant bacterial strains DOI
Yingnan Wang,

Conglai Zheng,

Mengting Qiu

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 928, P. 172444 - 172444

Published: April 16, 2024

Language: Английский

Citations

2
Effect of non-antibiotic factors on conjugative transfer of antibiotic resistance genes in aquaculture water DOI

Chendong Zhao,

Bongkotrat Suyamud, Yue Yuan

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 483, P. 136701 - 136701

Published: Nov. 28, 2024

Language: Английский

Citations

2
Analytical method for the determination of usually prescribed antibiotics in human nails using UHPLC-MS/MS. Comparison of the efficiency of two extraction techniques DOI

María del Carmen Gómez-Regalado,

Lydia Espín-Moreno, Laura Martín-Pozo

et al.

Talanta, Journal Year: 2023, Volume and Issue: 262, P. 124687 - 124687

Published: May 18, 2023

Language: Английский

Citations

4
Cylindrospermopsin enhances the conjugative transfer of plasmid-mediated multi-antibiotic resistance genes through glutathione biosynthesis inhibition DOI Creative Commons
Shuran Yang,

Jinrui Cao,

Zhao Chen

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 276, P. 116288 - 116288

Published: April 5, 2024

Cylindrospermopsin (CYN), a cyanobacterial toxin, has been detected in the global water environment. However, information concerning potential environmental risk of CYN is limited, since majority previous studies have mainly focused on adverse health effects through contaminated drinking water. The present study reported that at environmentally relevant levels (0.1-100 μg/L) can significantly enhance conjugative transfer RP4 plasmid Escherichia coli genera, wherein application 10 μg/L led to maximum fold change ∼6.5- 16 h exposure. Meanwhile, evaluation underlying mechanisms revealed concentration exposure could increase oxidative stress bacterial cells, resulting ROS overproduction. In turn, this an upregulation antioxidant enzyme-related genes avoid attack. Further, inhibition synthesis glutathione (GSH) was also detected, which rapid depletion GSH cells and thus triggered SOS response promoted process. Increase cell membrane permeability, expression related pilus generation, ATP synthesis, gene were observed. These results highlight impact spread antimicrobial resistance environments.

Language: Английский

Citations

1