Regulating the N Coordination Environment of Co Single-Atom Nanozymes for Highly Efficient Oxidase Mimics

Nano Letters, Journal Year: 2023, Volume and Issue: 23(4), P. 1505 - 1513

Published: Feb. 3, 2023

Single-atom catalysts with well-defined atomic structures and precisely regulated coordination environments have been recognized as potential substitutes for natural metalloenzymes. Inspired by the metal structure of enzymes, we show here that oxidase-like activity single-atom Co greatly depends on their local N around catalytic sites. We synthesized a series different nitrogen numbers (Co–Nx(C), x = 2, 3, 4) demonstrated could be effectively tailored fine-tuning coordination. Among studied catalysts, Co–N3(C) three-coordinate atoms shows optimum oxygen adsorption robust reactive species (ROS) generation, thus presenting preferable activity. This work facilitates future development rational nanozyme designs targeting reactions at level.

Language: Английский

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Fe-N-C single-atom nanozyme for ultrasensitive, on-site and multiplex detection of mycotoxins using lateral flow immunoassay

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 441, P. 129853 - 129853

Published: Sept. 1, 2022

Language: Английский

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Nanozyme-based biosensor for organophosphorus pesticide monitoring: Functional design, biosensing strategy, and detection application

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 165, P. 117152 - 117152

Published: June 20, 2023

Language: Английский

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A Cardiac‐Targeted Nanozyme Interrupts the Inflammation‐Free Radical Cycle in Myocardial Infarction

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(2)

Published: Nov. 21, 2023

Abstract Severe systemic inflammation following myocardial infarction (MI) is a major cause of patient mortality. MI‐induced can trigger the production free radicals, which in turn ultimately leads to increased cardiac lesions (i.e., inflammation‐free radicals cycle), resulting heart failure and death. However, currently available anti‐inflammatory drugs have limited efficacy due their weak effect poor accumulation at site. Herein, novel Fe‐Cur@TA nanozyme developed for targeted therapy MI, generated by coordinating Fe 3+ drug curcumin (Cur) with further modification tannic acid (TA). Such exhibits excellent scavenging properties reducing immune cell infiltration, promoting macrophage polarization toward M2‐like phenotype, suppressing inflammatory cytokine secretion, blocking cycle. Furthermore, high affinity TA tissue, shows an almost tenfold greater retention uptake than Fe‐Cur. In mouse preclinical beagle dog MI models, preserves function reduces scar size, suggesting promising potential clinical translation cardiovascular disease.

Language: Английский

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Research progress of nanozymes in colorimetric biosensing: Classification, activity and application

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 487, P. 150612 - 150612

Published: March 21, 2024

Language: Английский

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Application of Nanozymes in Environmental Monitoring, Management, and Protection

Biosensors, Journal Year: 2023, Volume and Issue: 13(3), P. 314 - 314

Published: Feb. 24, 2023

Nanozymes are nanomaterials with enzyme-like activity, possessing the unique properties of and natural catalytic functions. catalytically active, stable, tunable, recyclable, versatile. Therefore, increasing attention has been paid in fields environmental science life sciences. In this review, we focused on most recent applications nanozymes for monitoring, management, protection. We firstly introduce tuning activity according to some crucial factors such as size shape, composition doping, surface coating. Then, application introduced detail. can not only be used detect inorganic ions, molecules, organics, foodborne pathogenic bacteria but also involved degradation phenolic compounds, dyes, antibiotics. The capability was reported assisting air purification, constructing biofuel cells, marine antibacterial fouling removal. Finally, current challenges future trends toward proposed discussed.

Language: Английский

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Enzyme Core Spherical Nucleic Acid That Enables Enhanced Cuproptosis and Antitumor Immune Response through Alleviating Tumor Hypoxia

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(20), P. 13805 - 13816

Published: March 29, 2024

Cuproptosis, a copper-dependent cell death process, has been confirmed to further activate the immune response and mediate resistance. However, hypoxic tumor microenvironment hampers cuproptosis sensitivity suppresses body's antitumor response. Herein, we have successfully immobilized functionalized catalase (CAT) with long single-stranded DNA containing polyvalent CpG sequences through rolling circle amplification (RCA) techniques, obtaining an enzyme-cored spherical nucleic acid nanoplatform (CAT-ecSNA-Cu) deliver copper ions for cuproptosis. The presence of long-stranded DNA-protected CAT enhances mitochondrial respiration by catalyzing conversion H2O2 O2, thereby sensitizing Meanwhile, increased oxygenation expression hypoxia-inducible factor-1 (HIF-1) protein, resulting in alleviation immunosuppressive microenvironment. Of note, induces immunogenic (ICD), which facilitates dendritic (DC) maturation antigen presentation polyCpG-supported Toll-like receptor 9 (TLR9) activation. Furthermore, cuproptosis-induced PD-L1 upregulation cells complements checkpoint blockers (αPD-L1), enhancing immunity. strategy cuproptosis-mediated responses alleviating hypoxia effectively promotes activation proliferation effector T cells, ultimately leading long-term immunity against cancer.

Language: Английский

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Digitalization of Colorimetric Sensor Technologies for Food Safety

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: June 25, 2024

Abstract Colorimetric sensors play a crucial role in promoting on‐site testing, enabling the detection and/or quantification of various analytes based on changes color. These offer several advantages, such as simplicity, cost‐effectiveness, and visual readouts, making them suitable for wide range applications, including food safety monitoring. A critical component portable colorimetric involves their integration with color models effective analysis interpretation output signals. The most commonly used include CIELAB (Commission Internationale de l'Eclairage), RGB (Red, Green, Blue), HSV (Hue, Saturation, Value). This review outlines use via digitalization sensing applications within monitoring field. Additionally, challenges, future directions, considerations are discussed, highlighting significant gap integrating comparative toward determining model that results highest sensor performance. aim this is to underline potential mitigating global impact spoilage contamination health economy, proposing multidisciplinary approach harness full capabilities ensuring safety.

Language: Английский

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Self-assembled C-Ag hybrid nanoparticle on nanoporous GaN enabled ultra-high enhancement factor SERS sensor for sensitive thiram detection

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 469, P. 133868 - 133868

Published: Feb. 24, 2024

Language: Английский

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Biomimetic cascade intelligent paper chip sensor based on bimetallic porphyrin-based covalent organic framework with triple-enzyme mimetic activities

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 490, P. 151628 - 151628

Published: April 25, 2024

Language: Английский

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