Microbial Cell Factories,
Journal Year:
2024,
Volume and Issue:
23(1)
Published: May 22, 2024
Abstract
Fengycin
is
an
important
member
of
the
lipopeptide
family
with
a
wide
range
applications
in
agricultural,
food,
medical
and
cosmetic
industries.
However,
its
commercial
application
severely
hindered
by
low
productivity
high
cost.
Therefore,
numerous
studies
have
been
devoted
to
improving
production
fengycin.
We
summarize
these
this
review
aim
providing
reference
guidance
for
future
researchers.
This
begins
overview
synthesis
mechanism
fengycin
via
non-ribosomal
peptide
synthetases
(NRPS),
then
delves
into
strategies
recent
years.
These
mainly
include
fermentation
optimization
metabolic
engineering,
engineering
encompasses
enhancement
precursor
supply,
regulatory
factors,
promoter
genome-engineering
(genome
shuffling
genome-scale
network
model).
Finally,
we
conclude
prospect
production.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
34(1)
Published: Sept. 15, 2023
Abstract
Methicillin‐resistant
Staphylococcus
aureus
(MRSA)
is
threatening
human
health
due
to
its
resistance
multiple
antibiotics.
Excessive
copper
(Cu)
ions
target
the
lipoylated
proteins
of
tricarboxylic
acid
cycle
cancer
cells,
inducing
proteotoxic
stress
and
their
cuproptosis
death.
Whether
plays
a
part
in
killing
MRSA
by
low‐dose
supplement
Cu
remains
be
explored.
Herein,
Cu‐doped
hydroxyapatite
nanorods
(PC)
are
prepared
on
polyetheretherketone
(PEEK)
resist
infection
improve
PEEK
performance
tissue
integration
with
assistance
near‐infrared
(NIR)
irradiation,
mechanism
against
elucidated.
Mild
photothermal
stimulation
increases
bacterial
membrane
permeability,
accelerating
ions’
intake
consequently
cuproptosis‐like
death
MRSA.
It
confirmed
aggregation
dihydrolipoamide
S‐acetyltrans‐ferase
(DLAT),
deactivation
glutathione
peroxides
4
(GPX4),
destabilization
Fe─S
cluster
ferredoxin
(FDX1)
lipoyl
synthase
(LIAS).
Fortunately,
fibroblast
behaviors
upregulated
NIR‐irradiated
PC.
In
vivo,
PC
NIR
irradiation
exhibits
outstanding
elimination,
reduced
inflammation
response,
improved
biointegration.
Overall,
it
demonstrated
that
can
induced
at
non‐cytotoxic
dose
when
cooperated
mild
heat
stimulus,
this
strategy
has
greatly
promising
application
improving
clinic.
