Melatonin alleviates high temperature exposure induced fetal growth restriction via the gut-placenta-fetus axis in pregnant mice

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 1, 2024

Global warming augments the risk of adverse pregnancy outcomes in vulnerable expectant mothers. Pioneering investigations into heat stress (HS) have predominantly centered on its direct impact reproductive functions, while potential roles gut microbiota, despite significant influence distant tissues, remain largely unexplored. Our understanding deleterious mechanisms HS and development effective intervention strategies to mitigate detrimental impacts are still limited.

Language: Английский

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Current landscape of fecal microbiota transplantation in treating depression

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 25, 2024

Depression, projected to be the predominant contributor global disease burden, is a complex condition with diverse symptoms including mood disturbances and cognitive impairments. Traditional treatments such as medication psychotherapy often fall short, prompting pursuit of alternative interventions. Recent research has highlighted significant role gut microbiota in mental health, influencing emotional neural regulation. Fecal transplantation (FMT), infusion fecal matter from healthy donor into patient, emerges promising strategy ameliorate depressive by restoring microbial balance. The microbial-gut-brain (MGB) axis represents critical pathway through which potentially rectify dysbiosis modulate neuropsychiatric outcomes. Preclinical studies reveal that FMT can enhance neurochemicals reduce inflammatory markers, thereby alleviating behaviors. Moreover, shown promise clinical settings, improving gastrointestinal overall quality life patients depression. review highlights gut-brain depression need for further validate long-term safety efficacy FMT, identify specific therapeutic strains, develop targeted modulation strategies. Advancing our understanding could revolutionize treatment, shifting paradigm toward microbiome-targeting therapies.

Language: Английский

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Fecal microbiota transplantation alleviates experimental colitis through the Toll-like receptor 4 signaling pathway

World Journal of Gastroenterology, Journal Year: 2023, Volume and Issue: 29(30), P. 4657 - 4670

Published: Aug. 9, 2023

Fecal microbiota transplantation (FMT) has shown promising therapeutic effects on mice with experimental colitis and patients ulcerative (UC). FMT modulates the Toll-like receptor 4 (TLR4) signaling pathway to treat some other diseases. However, it remains unknown whether this modulation is also involved in treatment of UC.To clarify necessity TLR4 dextran sodium sulphate (DSS)-induced explain mechanism UC, through association analysis gut colon transcriptome mice.A mouse model was constructed wild-type (WT) TLR4-knockout (KO) mice. transplanted by gavage. Colon inflammation severity measured disease activity index (DAI) scoring hematoxylin eosin staining. Gut structure analyzed 16S ribosomal RNA sequencing. Gene expression obtained sequencing.The KO (DSS + Water) FMT) groups displayed indistinguishable body weight loss, length, DAI score, histology which showed that could not inhibit In treated FMT, relative abundance Akkermansia decreased, Lactobacillus became dominant. particular, compared those WT mice, scores were clearly decreased KO-DSS group. Microbiota a significant difference between dominant genus healthy The ineffectiveness related Akkermansia. Ontology enrichment differentially expressed genes each group mainly cytoplasmic translation cellular response DNA damage stimulus. top nine correlating included Aqp4, Clca4a, Dpm3, Fau, Mcrip1, Meis3, Nupr1 L, Pank3, Rps13 (|R| > 0.9, P < 0.01).FMT may ameliorate DSS-induced regulating pathway. composition maintain stability intestinal environment. bear great potential for colitis.

Language: Английский

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The Interplay between Medical Plants and Gut Microbiota in Cancer

Nutrients, Journal Year: 2023, Volume and Issue: 15(15), P. 3327 - 3327

Published: July 26, 2023

The gut microbiota is a dynamic community of bacteria distributed in the gastroenteric tract and changes response to diseases, diet, use antibiotics probiotics, hygiene status, other environmental factors. Dysbiosis, disruption normal crosstalk between host microbes, associated with obesity, diabetes, cancer, cardiovascular linked reduction anti-inflammatory like Lactobacillus Roseburia, an increase growth proinflammatory species Ruminococcus gnavus Bacteroidetes. Some plants possess anticancer properties various studies have reported that some these are also able modulate microbiota. aim this work evaluate crucial relationship medical consequences on onset progression cancer. In vivo about hematological malignancies showed beta-glucans tie endogenous antibeta glucan antibodies iC3b, opsonic fragment central complement protein C3, leading phagocytosis antibody-targeted neoplastic cells potentiation cytotoxic activity innate immune system if administered together monoclonal antibodies. conclusion, review suggests potential improve dysbiosis assist treatment

Language: Английский

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Modulation of gut microbiota with probiotics as a strategy to counteract endogenous and exogenous neurotoxicity

Advances in neurotoxicology, Journal Year: 2024, Volume and Issue: unknown, P. 133 - 176

Published: Jan. 1, 2024

Language: Английский

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A comprehensive review of arsenic-induced neurotoxicity: Exploring the role of glial cell pathways and mechanisms

Chemosphere, Journal Year: 2025, Volume and Issue: 372, P. 144046 - 144046

Published: Jan. 22, 2025

Language: Английский

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Chronic Arsenic Exposure Causes Alzheimer's Disease Characteristic Effects and the Intervention of Fecal Microbiota Transplantation in Rats

Journal of Applied Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

ABSTRACT Arsenic exposure and intestinal microbiota disorders may be related with Alzheimer's disease ( AD ), but the mechanism has not been elucidated. This study conducted chronic arsenic from rat's maternal body to adult offspring investigate mechanisms of characteristic effects on AD, further explored intervention effect fecal transplantation (FMT) arsenic‐mediated neurotoxicity. Transmission electron microscopy, HE staining, indicators were measured in control group, exposed FMT group. Western blot was used determine microtubule‐associated proteins Tau p‐Tau 396 , intestinal–brain barrier–related Claudin‐1 Occludin, ELISA detect content Aβ 1–42 16S rRNA sequencing flora feces. Results showed that could lead neurobehavioral defects rats, increase expression levels Tau, hippocampus p < 0.05), abundance Clostridium _ UCG‐014, decrease Roseburia Occludin colon 0.05). After intervention, decreased increased. In summary, caused disorder by changing inflammation‐related flora, thereby destroying gut–brain barrier causing rats. Although bacterial specific genus improved ‐related reduced after transplantation, it alleviate neurotoxicity exposure.

Language: Английский

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Could the gut microbiota be capable of making individuals more or less susceptible to environmental toxicants?

Toxicology, Journal Year: 2024, Volume and Issue: 503, P. 153751 - 153751

Published: Feb. 13, 2024

Language: Английский

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Prevalence of perturbed gut microbiota in pathophysiology of arsenic-induced anxiety- and depression-like behaviour in mice

Chemosphere, Journal Year: 2024, Volume and Issue: 364, P. 143293 - 143293

Published: Sept. 1, 2024

Language: Английский

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Associations of Microbiome Pathophysiology with Social Activity and Behavior are Mediated by Epigenetic Modulations: Avenues for Designing Innovative Therapeutic Strategies

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 106208 - 106208

Published: May 1, 2025

Language: Английский

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