Microplastics: an often-overlooked issue in the transition from chronic inflammation to cancer

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 22, 2024

The presence of microplastics within the human body has raised significant concerns about their potential health implications. Numerous studies have supported hypothesis that accumulation can trigger inflammatory responses, disrupt microbiome, and provoke immune reactions due to physicochemical properties. Chronic inflammation, characterized by tissue damage, angiogenesis, fibrosis, plays a crucial role in cancer development. It influences progression altering tumor microenvironment impairing surveillance, thus promoting tumorigenesis metastasis. This review explores fundamental properties bioaccumulation microplastics, as well transition from chronic inflammation carcinogenesis. Additionally, it provides comprehensive overview associated alterations signaling pathways, microbiota disturbances, responses. Despite this, current understanding toxicity biological impacts remains limited. To mitigate harmful effects on health, there is an urgent need improve detection removal methods for necessitating further research elucidation.

Language: Английский

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Nanoplastic-Induced Antibody Liquid-liquid Phase Separation: Insights into Potential Immunotoxic Implications

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 487, P. 137170 - 137170

Published: Jan. 9, 2025

Language: Английский

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Plastic nanoparticle toxicity is accentuated in the immune-competent inflamed intestinal tri-culture cell model

Nanotoxicology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15

Published: Jan. 22, 2025

Introduction: Important cell-based models of intestinal inflammation have been advanced in hopes predicting the impact nanoparticles on disease. We sought to determine whether a high level and extended exposure nanoplastic might result added caused by reported mouse model irritable bowel Methods: The cell consist Transwell©-type insert with filter membrane upon which lies biculture monolayer Caco-2 HT29-MTX-E12 made up barrier cells (apical compartment). This was exposed digested 40 nm diameter polymethacrylate (PMA) surface-functionalized COOH (PMA-) or NH2 (PMA+) at 'low level' (143 µg/cm2 surface area) 'high (571 µg/cm2) for 24 48 h. Beyond apical compartment well tissue culture plate, macrophages, previously differentiated from THP-1 (basolateral Thus, immune competent tri-cultures were examined as two models: healthy inflamed. inflamed model, having activated IFN-γ macrophages LPS expressed greater secretion pro-inflammation cytokines. Results: Sedimentation, Diffusion Dosimetry (ISDD) simulated that 8%-12% PMA deposited onto 24-48-h. structure disorganized both PMA, level, 48-h experiments. While neither amount nor duration influenced lactate dehydrogenase (LDH) only levels PMA- PMA+ experiments resulted significantly increased LDH secreted compared control. study is first show an additive intestine.

Language: Английский

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Studying mercury and polymethyl methacrylate joint effects on endogenous hydrogen polysulfides via fluorescence imaging

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 489, P. 137643 - 137643

Published: Feb. 17, 2025

Language: Английский

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Biological Effects of Micro-/Nano-Plastics in Macrophages

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(5), P. 394 - 394

Published: March 4, 2025

The environmental impact of plastics is worsened by their inadequate end-of-life disposal, leading to the ubiquitous presence micro- (MPs) and nanosized (NPs) plastic particles. MPs NPs are thus widely present in water air inevitably enter food chain, with inhalation ingestion as main exposure routes for humans. Many recent studies have demonstrated that gain access several body compartments, where they taken up cells, increase production reactive oxygen species, lead inflammatory changes. In most tissues, resident macrophages engage first approach foreign materials, this interaction largely affects subsequent fate material possible pathological outcomes. On other hand, organizers controllers both responses tissue repair. Here, we aim summarize available information on NPs. Particular attention will be devoted consequences macrophage viability functions, well implications pathology.

Language: Английский

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Bridging relevance between microplastics, human health and bone metabolism: Emerging threats and research directions

Environmental Chemistry and Ecotoxicology, Journal Year: 2024, Volume and Issue: 6, P. 422 - 435

Published: Jan. 1, 2024

Language: Английский

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Short-term oral exposure to nanoplastics does not significantly impact the antiviral immune response of the mouse

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 488, P. 137316 - 137316

Published: Jan. 21, 2025

Language: Английский

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Effects of microplastics on the immune system: How much should we worry?

Immunology Letters, Journal Year: 2025, Volume and Issue: 272, P. 106976 - 106976

Published: Feb. 1, 2025

Plastics are everywhere. It is widely recognized that they represent a global problem, the extent of which yet to be defined. Humans broadly exposed plastics, whose effects and consequences poorly characterized so far. The main route exposure via alimentary respiratory intake. pollutions may come from both: water food contamination itself, their packaging. smaller sizes (i.e. microplastics <150 µm - MPs) considered most pervasive living organisms and, therefore, potentially harmful. As humans occupy one apex positions chain, we bioaccumulation biomagnification MPs. In fact, MPs commonly found in human stools blood. However, there no data available on ability accumulate produce detrimental biological systems. Even though plastics pollution studied mammals, including humans, appear have inflammatory effects, rather concerning as many etiologies disease based pro-inflammatory status.

Language: Английский

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Role of microplastics in the tumor microenvironment (Review)

Oncology Letters, Journal Year: 2025, Volume and Issue: 29(4), P. 1 - 14

Published: Feb. 21, 2025

Microplastics (MPs) are pervasive in several ecosystems and have the potential to infiltrate multiple aspects of human life through ingestion, inhalation dermal exposure, thus eliciting substantial concerns regarding their implications for health. Whilst initial research has documented effects MPs on disease development across physiological systems, may also facilitate tumor progression by influencing microenvironment (TME). This evolving focus underscores growing interest role tumorigenesis interactions within TME. In present review, relationship between TME is comprehensively assessed, providing a detailed analysis with cells, stromal cells (including macrophages, fibroblasts endothelial cells), extracellular matrix inflammatory processes. Recommendations future directions strategies address reduce microplastic pollution proposed.

Language: Английский

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Microplastics and potential damage to human cells

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 405 - 416

Published: Jan. 1, 2025

Language: Английский

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