Mechanistic insights regarding neuropsychiatric and neuropathologic impacts of air pollution DOI
Katherine M. Rentschler, Urmila P. Kodavanti

Critical Reviews in Toxicology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 28

Published: Dec. 10, 2024

Air pollution is a significant environmental health risk for urban areas and developing countries. may contribute to the incidence of cardiopulmonary metabolic diseases. Evidence also points role air in worsening or neurological neuropsychiatric conditions. Inhaled pollutants include compositionally differing mixtures respirable gaseous particulate components varied sizes, solubilities, chemistry. Inhalation combustibles volatile organic compounds (VOCs) other irritant matter (PM) trigger lung sensory afferents which initiate sympathetic stress response via activation hypothalamic-pituitary-adrenal (HPA) sympathetic-adrenal-medullary (SAM) axes. Activation SAM HPA axes are associated with selective inhibition hypothalamic-pituitary-gonadal (HPG) hypothalamic-pituitary-thyroid (HPT) following exposure. Regarding chronic exposure susceptible hosts, these changes become pathological by causing neuroinflammation, neurotransmitter, neuroendocrine imbalances. Soluble PM, such as metals nano-size particles translocate across olfactory, trigeminal, vagal nerves through retrograde axonal transport, systemic circulation disrupt blood-brain barrier (BBB) deposit neural tissue. Neuronal deposition metallic can have negative impact multiple molecular mechanisms. In addition translocation, release pituitary hormones, altered hormonal status resultant circulating milieu, sympathetically HPA-mediated immune markers, secondarily brain variety regulatory adrenal hormone-dependent Several reviews covering factor disorders been published, but no discuss in-depth intersection between stress-related mechanisms, thereby addressing adaptation susceptibility variations link peripheral tissue effects. The purpose this review evidence regarding neurochemical, neuroendocrine, mechanisms neuropathology from This covers bi-directional interactions raise pollution-related illness.

Language: Английский

Crosstalk between gut microbiotas and fatty acid metabolism in colorectal cancer DOI Creative Commons
Hao Zhang, Yuan Tian, Chunjie Xu

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Feb. 26, 2025

Abstract Colorectal cancer (CRC) is the third most common malignancy globally and second leading cause of cancer-related mortality. Its development a multifactorial multistage process influenced by dynamic interplay between gut microbiota, environmental factors, fatty acid metabolism. Dysbiosis intestinal microbiota abnormalities in microbiota-associated metabolites have been implicated colorectal carcinogenesis, highlighting pivotal role microbial metabolic interactions. Fatty metabolism serves as critical nexus linking dietary patterns with activity, significantly impacting health. In CRC patients, reduced levels short-chain acids (SCFAs) SCFA-producing bacteria consistently observed. Supplementation probiotics has demonstrated tumor-suppressive effects, while therapeutic strategies aimed at modulating SCFA shown potential enhancing efficacy radiation therapy immunotherapy both preclinical clinical settings. This review explores intricate relationship metabolism, CRC, offering insights into underlying mechanisms their translational applications. Understanding this could pave way for novel diagnostic, therapeutic, preventive management CRC.

Language: Английский

Citations

2
Pollutants, microbiota and immune system: frenemies within the gut DOI Creative Commons
Pierluigi Rio, Antonio Gasbarrini,

Giovanni Gambassi

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: May 10, 2024

Pollution is a critical concern of modern society for its heterogeneous effects on human health, despite widespread lack awareness. Environmental pollutants promote several pathologies through different molecular mechanisms. Pollutants can affect the immune system and related pathways, perturbing regulation triggering pro-inflammatory responses. The exposure to also leads alterations in gut microbiota with decreasing abundance beneficial microbes, such as short-chain fatty acid-producing bacteria, an overgrowth species. subsequent intestinal barrier dysfunction, together oxidative stress increased inflammatory responses, plays role pathogenesis gastrointestinal diseases. Moreover, encourage inflammation-dysplasia-carcinoma sequence various mechanisms, stress, dysregulation cellular signalling cell cycle impairment genomic instability. In this narrative review, we will describe interplay between pollutants, microbiota, system, focusing their relationship bowel diseases colorectal cancer. Understanding biological mechanisms underlying health-to-disease transition may allow design public health policies aimed at reducing burden disease pollutants.

Language: Английский

Citations

8
Sleep and Arousal Hubs and Ferromagnetic Ultrafine Particulate Matter and Nanoparticle Motion Under Electromagnetic Fields: Neurodegeneration, Sleep Disorders, Orexinergic Neurons, and Air Pollution in Young Urbanites DOI Creative Commons
Lilian Calderón‐Garcidueñas, Rubén Cejudo, Elijah W. Stommel

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(4), P. 284 - 284

Published: April 8, 2025

Air pollution plays a key role in sleep disorders and neurodegeneration. Alzheimer’s disease (AD), Parkinson’s (PD), and/or transactive response DNA-binding protein TDP-43 neuropathology have been documented children young adult forensic autopsies the metropolitan area of Mexico City (MMC), along with disorders, cognitive deficits, MRI brain atrophy seemingly healthy populations. Ultrafine particulate matter (UFPM) industrial nanoparticles (NPs) reach urbanites’ brains through nasal/olfactory, lung, gastrointestinal tract, placental barriers. We Fe UFPM/NPs neurovascular units, as well lateral hypothalamic nucleus orexinergic neurons, thalamus, medullary, pontine, mesencephalic reticular formation, pinealocytes. quantified ferromagnetic materials arousal hubs examined their motion behavior to low magnetic fields MMC autopsy samples from nine 25 adults AD, PD, neuropathology. Saturated isothermal remanent magnetization curves at 50–300 mT were associated UFPM/NP accumulation sleep/awake 30–50 µT (DC fields) exposure. Brain exposed anthropogenic PM found be sensitive fields, behaviors that potentially linked early development progression fatal neurodegenerative diseases disorders. Single-domain orexin system, arousal, sleep, autonomic regions, are neurodegeneration, behavioral impairment, need identify higher risk monitor environmental UFPM NP emissions exposures fields. Ubiquitous ferrimagnetic particles field threat global health.

Language: Английский

Citations

0
Gut microbiota-derived gamma-aminobutyric acid improves host appetite by inhibiting satiety hormone secretion DOI Creative Commons

Shouren Li,

Mengqi Liu, Han Yao

et al.

mSystems, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 24, 2024

ABSTRACT Globally, appetite disorders have become an increasingly prominent public health issue. While short-term loss may seem relatively harmless, prolonged instances can lead to serious physical and mental damage. In recent years, numerous studies highlighted the significant role of “microbiota-gut-brain” axis in regulation feeding behavior organisms, suggesting that targeting gut microbiota be a novel therapeutic strategy for disorders. However, molecular mechanisms through which mediates increase host causal relationship between two remain unclear. Based on this, we conducted 16S rRNA sequencing analyze rabbits with high low feed intake, followed by fecal transplantation (FMT) metabolite gavage experiments elucidate underlying mechanisms. Our research indicates intake group exhibited enrichment g__Bacteroides gamma-aminobutyric acid (GABA), intragastric administration GABA effectively promoted host’s behavior. The mechanism involves derived from inhibiting secretion satiety hormones enhance Furthermore, results FMT suggest differences composition contributing factor varying levels host. conclusion, these findings emphasize microbiota-derived GABA, increasing offering new target treatment perspective microbiota. IMPORTANCE incidence anorexia is rapidly has global burden. Gut participate behavior, yet them this study, utilized investigate employed gastric infusion (GABA) potential involved. hormones. This discovery underscores pivotal modulating appetite, avenues targets

Language: Английский

Citations

3
Interaction of diesel exhaust particulate matter with mucins in simulated saliva fluids: Bioaccessibility of heavy metals and potential health risks DOI
Jiao Li,

Haorang Song,

Linfeng Zhang

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 135811 - 135811

Published: Sept. 10, 2024

Language: Английский

Citations

2
Mangosteen Extract reduces the bacterial load of eggshell and improves egg quality DOI Creative Commons
Jianfei Zhu, Qing Liu, Yongqiang Wang

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(15), P. e35857 - e35857

Published: Aug. 1, 2024

The increasing emergence and spread of antibiotic resistance accelerate the desire for alternatives. Plant extracts have emerged as a promising relatively unexplored area research potential substitutes. Herein, we investigated prevalence distribution patterns bacteria on egg surfaces evaluated inhibitory effects mangosteen extract these surface bacteria. In addition, examined antioxidant activity quality in improving ability extract. results showed that predominant isolated from eggshells were Gram-positive, with

Language: Английский

Citations

1
Integrated Microbiome and Metabolome Analysis Reveals Hypothalamic‐Comorbidities Related Signatures in Craniopharyngioma DOI Creative Commons
Ben Lin, Zhen Ye, Zhan Yi Cao

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 3, 2024

Abstract Craniopharyngioma (CP) is an intracranial tumor with high mortality and morbidity. Though biologically benign, CP will damage the hypothalamus, inducing comorbidities such as obesity, metabolic syndrome, cognitive impairments. The roles of gut microbiome serum metabolome in CP‐associated hypothalamic are aimed to be explored. Patients characterized by increased Shannon diversity, Eubacterium , Clostridium Roseburia alongside decreased Alistipes Bacteroides . CP‐enriched taxa positively correlated dyslipidemia decline, while CP‐depleted negatively associated fatty liver. Subsequent metabolomics identified notably up‐regulated purine metabolism, integrative analysis indicated association between altered microbiota elevated hypoxanthine. Phenotypic study multi‐omics Rax‐CreER T2 ::Braf V600E/+ ::Pten Flox/+ mouse model validated potential involvement dysregulated metabolism comorbidities. To further consolidate this, intervention experiments performed it found that hypoxanthine co‐variated severity abundance induced along redox imbalance target organs (liver brain cortex). Overall, demonstrated signatures hypothalamic‐comorbidities, unveiled may mediate development progression hypothalamic‐comorbidities.

Language: Английский

Citations

1
Caveolae with serotonin and NMDA receptors as promising targets for the treatment of Alzheimer’s disease DOI

Moeka Nakashima,

Naoko Suga,

Akari Fukumoto

et al.

International Journal of Physiology Pathophysiology and Pharmacology, Journal Year: 2024, Volume and Issue: 16(5), P. 96 - 110

Published: Jan. 1, 2024

Alzheimer's disease is the most general type of cognitive impairments. Until recently, strategies that prevent its clinical progression have remained more elusive. Consequently, research direction should be for finding effective neuroprotective agents. It has been suggested oxidative stress, mitochondrial injury, and inflammation level might lead to brain cell death in many neurological disorders. Therefore, several autophagy-targeted bioactive compounds may promising candidate therapeutics prevention damage. Interestingly, some risk genes are expressed within cells, which linked cholesterol metabolism, lipid transport, endocytosis, exocytosis and/or caveolae formation, suggesting a fruitful therapeutic target improve This review would highlight latest advances technologies treatment disease. In particular, paradigm serotonin N-methyl-d-aspartate (NMDA) receptors agonist/antagonist structure possibly impairment. cellular membrane biophysics our understanding pathology dysfunction associated with Here, this purpose therapy open potential move care toward disease-modifying certain benefits patients.

Language: Английский

Citations

1
Exposure to Diesel-Related Particulate Matter, Cortisol Stress Responsivity, and Depressive Symptoms in Adolescents DOI
Jessica P. Uy,

K R Shin,

Jessica L. Buthmann

et al.

Psychoneuroendocrinology, Journal Year: 2024, Volume and Issue: 171, P. 107214 - 107214

Published: Oct. 10, 2024

Language: Английский

Citations

0
Mechanistic insights regarding neuropsychiatric and neuropathologic impacts of air pollution DOI
Katherine M. Rentschler, Urmila P. Kodavanti

Critical Reviews in Toxicology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 28

Published: Dec. 10, 2024

Air pollution is a significant environmental health risk for urban areas and developing countries. may contribute to the incidence of cardiopulmonary metabolic diseases. Evidence also points role air in worsening or neurological neuropsychiatric conditions. Inhaled pollutants include compositionally differing mixtures respirable gaseous particulate components varied sizes, solubilities, chemistry. Inhalation combustibles volatile organic compounds (VOCs) other irritant matter (PM) trigger lung sensory afferents which initiate sympathetic stress response via activation hypothalamic-pituitary-adrenal (HPA) sympathetic-adrenal-medullary (SAM) axes. Activation SAM HPA axes are associated with selective inhibition hypothalamic-pituitary-gonadal (HPG) hypothalamic-pituitary-thyroid (HPT) following exposure. Regarding chronic exposure susceptible hosts, these changes become pathological by causing neuroinflammation, neurotransmitter, neuroendocrine imbalances. Soluble PM, such as metals nano-size particles translocate across olfactory, trigeminal, vagal nerves through retrograde axonal transport, systemic circulation disrupt blood-brain barrier (BBB) deposit neural tissue. Neuronal deposition metallic can have negative impact multiple molecular mechanisms. In addition translocation, release pituitary hormones, altered hormonal status resultant circulating milieu, sympathetically HPA-mediated immune markers, secondarily brain variety regulatory adrenal hormone-dependent Several reviews covering factor disorders been published, but no discuss in-depth intersection between stress-related mechanisms, thereby addressing adaptation susceptibility variations link peripheral tissue effects. The purpose this review evidence regarding neurochemical, neuroendocrine, mechanisms neuropathology from This covers bi-directional interactions raise pollution-related illness.

Language: Английский

Citations

0