6‐Chloronicotinic Acid Induces Toxicity in Mouse Neural Stem Cells via the C3ar1 Signaling DOI Open Access
Min He,

Yahang Lin,

Xiaojing Zhang

et al.

Journal of Applied Toxicology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 29, 2024

ABSTRACT Neural stem cells (NSCs) are essential for brain development due to their ability proliferate and differentiate into various neural cell types. Neonicotinoid insecticides (NNIs), which have replaced traditional pesticides, now widely used frequently detected in environmental biological samples. Prenatal exposure NNIs has been associated with an increased risk of neurodevelopmental disorders offspring, yet the causal relationship underpinning mechanism remain be clarified. As one primary metabolites chloropyridinyl neonicotinoids, 6‐chloronicotinic acid (6‐ClNA) identified as a potential neurotoxin, though its effects on NSCs not fully explored. Here, we demonstrate that 6‐ClNA significantly disrupted NSC proliferation differentiation vitro. Transcriptomic analyses revealed altered expression pathways related proliferation, apoptosis, inflammation, notable activation C3ar1/C1qa signaling axis. Genetic ablation C3ar1 using siRNA markedly restored neurosphere formation, well reduced suggesting central role mediating 6‐ClNA's neurotoxic effects. These findings imply early‐life may affect fitness function NSCs, wherein pathway plays indispensable role.

Language: Английский

SIRIUS-assisted elucidation of global impurities in high purity acetamiprid DOI
Mengling Tu, Wen Ma, Yunxiao Zhu

et al.

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113060 - 113060

Published: Feb. 1, 2025

Language: Английский

Citations

1
Insight of neonicotinoid insecticides: Exploring Exposure, Mechanisms in Non-Target Organisms, and Removal Technologies DOI Creative Commons
Yuanyuan Zhang,

Wanxuan Zhu,

Ying Wang

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 209, P. 107415 - 107415

Published: Sept. 19, 2024

Language: Английский

Citations

5
Impact de l’exposition prénatale et postnatale aux pesticides sur les nouveau-nés et nourrissons DOI Creative Commons

Zeina Halbouty,

Pierre Tourneux, Élodie Haraux

et al.

Perfectionnement en Pédiatrie, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Citations

0
Enhanced detection of acetamiprid via a gold nanoparticle-based colorimetric aptasensor integrated with a hybridization chain reaction DOI
Xingyi Liu, Mingming Li, Hao Wang

et al.

Analytical Methods, Journal Year: 2024, Volume and Issue: 16(26), P. 4301 - 4309

Published: Jan. 1, 2024

A novel colorimetric and fluorescent aptasensor integrating gold nanoparticles a hybridization chain reaction for enhanced detection of acetamiprid in food safety applications.

Language: Английский

Citations

0
6‐Chloronicotinic Acid Induces Toxicity in Mouse Neural Stem Cells via the C3ar1 Signaling DOI Open Access
Min He,

Yahang Lin,

Xiaojing Zhang

et al.

Journal of Applied Toxicology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 29, 2024

ABSTRACT Neural stem cells (NSCs) are essential for brain development due to their ability proliferate and differentiate into various neural cell types. Neonicotinoid insecticides (NNIs), which have replaced traditional pesticides, now widely used frequently detected in environmental biological samples. Prenatal exposure NNIs has been associated with an increased risk of neurodevelopmental disorders offspring, yet the causal relationship underpinning mechanism remain be clarified. As one primary metabolites chloropyridinyl neonicotinoids, 6‐chloronicotinic acid (6‐ClNA) identified as a potential neurotoxin, though its effects on NSCs not fully explored. Here, we demonstrate that 6‐ClNA significantly disrupted NSC proliferation differentiation vitro. Transcriptomic analyses revealed altered expression pathways related proliferation, apoptosis, inflammation, notable activation C3ar1/C1qa signaling axis. Genetic ablation C3ar1 using siRNA markedly restored neurosphere formation, well reduced suggesting central role mediating 6‐ClNA's neurotoxic effects. These findings imply early‐life may affect fitness function NSCs, wherein pathway plays indispensable role.

Language: Английский

Citations

0