Associations of systemic inflammation and systemic immune inflammation with serum uric acid concentration and hyperuricemia risk: the mediating effect of body mass index DOI Creative Commons

Yueyue Zhang,

Shichao Han, Zhizhou Duan

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 9, 2024

With the development of lifestyle, elevated uric acid and hyperuricemia have become important factors affecting human health, but biological mechanism risk are still unclear.

Language: Английский

Pioneering Sensing Technologies Using Borophene‐Based Composite/Hybrid Electrochemical Biosensors for Health Monitoring: A Perspective DOI Open Access
Shahzad Ahmed, Arshiya Ansari,

Syed Kashif Ali

et al.

Analysis & Sensing, Journal Year: 2024, Volume and Issue: 4(5)

Published: Aug. 7, 2024

Abstract Biosensors are analytical tools that integrate a biological element with physicochemical detector in order to quantify the existence or concentration of chemicals, biomolecules, other elements for human health monitoring purposes. Electrochemical techniques analyte detection include use electrochemical sensors identify and molecules. These often used because their high sensitivity, specificity, quick reaction time, possibility being made smaller size, but still, research problem electrochemical‐based biosensing largely revolves around improving biosensors′ selectivity, stability, response time. Borophene, an intriguing novel substance within domain two‐dimensional (2D) materials, emerges as highly promising protagonist continuous dynamic history nanoscience nanotechnology. characterized by its distinctive electronic, mechanical, thermal properties, enthralls scientists due atomic structure consisting exclusively boron atoms organized honeycomb lattice. In recent years, borophene hybrids composites have emerged potentially fruitful avenues expanding utility numerous fields properties. addition, hybrid systems hold significant potential overcome limitations current biosensors. By leveraging unique properties—such surface area, chemical versatility, mechanical strength—these materials can improve limitations. Moreover, integration further optimize performance, paving way advanced practical solutions. This perspective presents synopsis developments based on borophene, including polymers nanomaterials. we emphasized remarkable characteristics hybrids, which permit analytes such proteins, nucleic acids, small molecules sensitive selective manner. Additionally, summary computational investigations into utilizing borophene‐based has been provided. nutshell, discussed challenges future directions field, outlining opportunities innovation optimization platforms.

Language: Английский

Citations

11
Kidney function mediates the association of per- and poly-fluoroalkyl substances (PFAS) and heavy metals with hepatic fibrosis risk DOI
Zhengqi Wei,

Jincheng Liu,

Na Wang

et al.

Environmental Research, Journal Year: 2024, Volume and Issue: unknown, P. 120092 - 120092

Published: Sept. 1, 2024

Language: Английский

Citations

6
Epidemiological perspectives on emerging contaminants and gout or hyperuricemia DOI Creative Commons

Weiwen Fu,

Yangyi Guang,

Zixing Zhang

et al.

Emerging contaminants, Journal Year: 2025, Volume and Issue: unknown, P. 100485 - 100485

Published: Feb. 1, 2025

Language: Английский

Citations

0
Gene-Environment Interactions Between Per- and Polyfluoroalkyl Substances (PFAS) and Folate-Related SNPs on Birth Weight and Head Circumference: Findings from the Taiwan Birth Panel Study DOI
Pau‐Chung Chen, Chih‐Fu Wei, Mei‐Huei Chen

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Abstract Background Folate metabolism is crucial for fetal development, while per- and polyfluoroalkyl substances (PFAS) are associated with adverse birth outcomes lower folate levels. However, no study tested the interaction between PFAS exposure genetic variations in pathway on outcomes. The investigated whether variants modify association prenatal Methods We analyzed data from 338 mother-infant pairs Taiwan Birth Panel Study. Cord blood concentrations of four were measured using ultra-performance liquid chromatography–tandem mass spectrometry. Infant genotypes assessed Biobank Array, we focused three previously identified single nucleotide polymorphisms (SNPs) related to five SNPs metabolism. Gene-environment interactions evaluated generalized linear regression two mixture models (quantile g-computation Bayesian kernel machine regression). Results Prenatal PFOS, PFUA, weight, associations weight head circumference varied by variants. found PFNA MTNR1B rs10830963, a weight-related SNP. Also, MTR rs1805087 AG/GG carriers had greater PFOS mixture-related reductions. Meanwhile, there stronger evidence mixture-birth HMGA2 rs1351394 CC rs1042725 TT carriers. Conclusion Genotypes size modified circumference.

Language: Английский

Citations

0
Association between organophosphate esters exposure and the prevalence of hyperuricemia in US adults from NHANES 2011–2016 DOI Creative Commons
Qiong Huang,

Wenbin Nan,

Siqi Li

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 6, 2025

Organophosphate esters (OPEs) exposure has potentially harmful effects on human health. However, the evidence between OPEs and hyperuricemia is insufficient. We aimed to assess association metabolites prevalence of hyperuricemia. Multivariable logistic regression, weighted quantile regression (WQS) model, Bayesian kernel machine (BKMR) models were used investigate with risk Mediation analysis was conducted whether inflammation mediated The multivariable logistics indicated that bis (1,3-dichloro-2-propyl) phosphate (BDCPP) bis-2-chloroethyl (BCEP) positively correlated In WQS BKMR analyses, mixtures presented a positive hyperuricemia, BDCPP being primary contributor. C-reactive protein (CRP) monocytes found mediate prevalence, 8.46% 3.97% proportion, respectively. Our study revealed identified as most significant Inflammation potential mechanism mediating effect

Language: Английский

Citations

0
Association between air temperature exposure and childhood rhinitis risk, and the mediating role of ambient O3: A multi-city study of 40,103 Chinese preschool children DOI
Zhiping Niu, Ling Zhang, Xin Zhang

et al.

Sustainable Cities and Society, Journal Year: 2025, Volume and Issue: unknown, P. 106122 - 106122

Published: Jan. 1, 2025

Language: Английский

Citations

0
Association between urinary metal concentrations and hyperuricemia in Chinese community-dwelling elderly: Exploring the mediating role of estimating glomerular filtration rate DOI Creative Commons
Zeyang Bai, Yuqing Dai,

Siyu Duan

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 292, P. 117943 - 117943

Published: Feb. 26, 2025

Language: Английский

Citations

0
α-Ketoglutarate modulates the mechanisms of toxicity in crucian carp kidneys chronically exposed to NaHCO3: Metabolomics insights DOI
Wenzhi Liu,

Lin Han,

Fangying Yuan

et al.

Comparative Biochemistry and Physiology Part D Genomics and Proteomics, Journal Year: 2025, Volume and Issue: 55, P. 101466 - 101466

Published: March 4, 2025

Language: Английский

Citations

0
Desmodium caudatum (Thunb.) DC. Extract Attenuates Hyperuricemia-Induced Renal Fibrosis via Modulating TGF-β1 Pathway and Uric Acid Transporters: Evidence from In Vitro and In Vivo Studies DOI
Hui‐Hsuan Lin,

Yu-Hsuan Liang,

Charng-Cherng Chyau

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119609 - 119609

Published: March 1, 2025

Language: Английский

Citations

0
Oxidative stress and inflammation mediate the adverse effects of cadmium exposure on all-cause and cause-specific mortality in patients with diabetes and prediabetes DOI Creative Commons
Jinlong Liu, Kehan Chen,

Mingyuan Tang

et al.

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 29, 2025

The effect of cadmium exposure on mortality risk among individuals with diabetes and prediabetes remains unclear, particularly regarding potential mediation by oxidative stress inflammation. This study aimed to investigate the associations blood levels all-cause, cardiovascular disease (CVD), cancer mediating effects inflammation biomarkers in patients prediabetes. In this prospective cohort study, we analyzed 17,687 adults from National Health Nutrition Examination Survey (NHANES, 1999-2018). Nine related (gamma-glutamyl transferase [GGT], uric acid [UA], high-density lipoprotein [HDL], UA HDL ratio [UHR]) (neutrophil-lymphocyte [NLR], monocyte-lymphocyte [MLR], neutrophil-monocyte-lymphocyte [NMLR], systemic response index [SIRI], immune-inflammation [SII]) were systematically assessed. Kaplan-Meier survival analysis, Cox proportional hazards models, restricted cubic splines (RCS) applied evaluate association risk. Generalized linear models used assess biomarkers, while regression RCS evaluated their mortality. Causal analysis identified biological pathways mediated Stratified sensitivity analyses further employed confirm robustness results. During 161,047.75 person-years follow-up, 3562 deaths occurred, including 1214 CVD 680 cancer. Higher associated increased risks all-cause (fully adjusted hazard [HR]: 2.17; 95% confidence interval [CI] 1.69-2.79, comparing highest vs. lowest quartile), (HR 2.06; CI 1.41-3.02), 2.38; 1.47-3.85), without evidence nonlinear relationship. Mediation indicated that UA, NLR, MLR, NMLR, SIRI partially mortality, although proportions relatively modest (ranging 1.4 4.8%). Additionally, GGT a small fraction Cadmium increases CVD, Oxidative appear mediate adverse effect. These findings emphasize urgent need for targeted interventions reduce cadmium-related risks. What is currently known about topic? linked are critical development complications. key research question? Does increase prediabetes? Are involved these effects? new? cause-specific associations. How might influence clinical practice? Monitor cadmium, stress,

Language: Английский

Citations

0