Global Trends and Burden of Malignant Neoplasm of Bone and Articular Cartilage in Adolescents: A Comprehensive Epidemiological Analysis from 1990 to 2021 with Future Projections to 2030

Published: Jan. 1, 2025

Language: Английский

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Global burden of Alzheimer’s disease and other dementias in adults aged 65 years and over, and health inequality related to SDI, 1990–2021: analysis of data from GBD 2021

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 3, 2025

Language: Английский

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Global burden trends and forecasts for MAFLD in adolescents and young adults from 1990 to 2021

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 19, 2025

Language: Английский

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Trends in burden and mortality of congenital birth defects in G20 countries (1990–2021) and predictions for 2022–2040

BMC Pregnancy and Childbirth, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 25, 2025

Congenital birth defects (CBDs) rank among the top five causes of death in children under age five. Despite their significant impact, studies on burden CBDs G20 countries remain limited. This study sought to examine temporal trends disease and mortality rates across from 1990 2021, identify potential risk factors contributing these trends, project for period 2022-2040. Data this were obtained Global Burden Disease (GBD) 2021 GBD 2019 databases. We analyzed disability-adjusted life years (DALYs) using absolute numbers, all-age rates, age-standardized (ASR), annual percent change (APC), average (AAPC). Joinpoint regression analysis was conducted periods ASR. Spearman correlation with locally weighted regression, supplemented by 10,000 bootstrap iterations robustness validation used associations between socio-demographic index (SDI), healthcare access quality (HAQ) index, Summary exposure value (SEV) factor exposure, Decomposition performed investigate driving behind changes CBDs. Finally, a Bayesian age-period-cohort (BAPC) model applied DALYs From total number deaths decreased 59.77% (95% UI: 68.14-35.22%) 63.81% 38.72-71.64%), respectively, more pronounced reduction observed males compared females. In India recorded highest deaths, followed China Indonesia. Mexico reported DALY rate (ASDR) (ASMR), Turkey, Argentina ranking third ASDR Brazil ASMR. heart anomalies (CHAs) remained leading cause ASMR digestive congenital (DCAs) second. indicated that most occurred 1995 (APC = -2.58, 95% CI: -2.61 -2.55), while -3.75, -4.75 -2.86). The ASR varied countries. revealed higher SDI HAQ exhibited lower (p < 0.01, BCa CI excluded zero). Eleven level-3 showed positive 0.05, zero), coefficients occupational noise, unsafe sanitation, vitamin A deficiency. aging epidemiological patterns contributed reductions -26.19% - 54.21% DALYs, population growth led 20.64% increase DALYs. BAPC predicted declining trend all future. Although has declined countries, disparities persist nations. To effectively reduce gaps, enhanced international cooperation, increased investment resources, implementation robust preventive measures are essential gap CBD

Language: Английский

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Global, regional, and national burden of cardiovascular disease attributable to high body mass index from 1990 to 2021 and projection to 2045

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: April 28, 2025

High body mass index (HBMI) is strongly associated with cardiovascular disease (CVD), but the global burden of CVD attributable to HBMI remains poorly defined. This study aims elucidate current and temporal trends HBMI. We used data from Global Burden Disease Study (GBD) 2021 estimate deaths disability-adjusted life years (DALYs) Our analysis examines in DALYs by age, gender, Socio-demographic Index (SDI) across global, regional, national levels 1990 2021. health inequality decomposition analyses quantify influencing factors a Bayesian age-period-cohort (BAPC) model predict potential trend on burden. In 2021, HBMI-related resulted approximately 1.9 million 45.43 among urban rural populations, an age-standardized mortality rate (ASMR) 22.77 (95% UI, 12.87-34.24) disability (ASDR) 529.00 277.28-808.64) per 100,000 people. Over period, overall decreased significantly, while atrial fibrillation flutter increased. The was closely tied socioeconomic development unevenly distributed, middle SDI regions experiencing heavier highest observed individuals aged 84 older, significant increase 20-44 age group. Decomposition revealed that driven population growth. Projections BAPC suggest 2045, may continue increase. provides comprehensive epidemiological assessment various offering valuable insights for guiding policy research efforts.

Language: Английский

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Chemical Characterization and Oxidative Potential of Persistent Organic Pollutants (POPs) in Size-Resolved Particulate Matter Across Industrial and Traffic Stations

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121747 - 121747

Published: May 1, 2025

Language: Английский

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Global Cancer Burden Attributable to Dietary Risks: Trends, Regional Disparities, and Future Projections (1990-2050)

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Background Cancer remains a leading global cause of death, with its burden increasingly influenced by demographic changes and dietary factors.Method This study utilized the Global Burden Disease (GBD) 2021 database to evaluate cancer burdens attributable risks from 1990 2021, accounting for variations age, gender, region, socioeconomic status. Trends through 2050 were projected using Bayesian Age-Period-Cohort model.Result Here we show that disability-adjusted life years (DALYs) declined 302.48 189.62 per 100,000 population (AAPC: -1.49%) over three decades, yet disparities remain prominent across Socio-Demographic Index (SDI) regions. High-SDI countries, such as Luxembourg, achieved substantial reductions, while low-SDI nations like Lesotho Zimbabwe experienced rising burdens, driven inadequate quality limited health resources. Key risks, including low intake whole grains, milk, red meat, demonstrated improvement in high-income countries but worsening trends many low- middle-income Projections suggest continued decline factors 2050, regions benefiting most, Latin America, Caribbean, North Africa, Middle East may experience slower progress or transient increases. Additionally, poor practices is expected rise sharply among individuals aged 75 older, underscoring compounding effects aging populations.Conclusion These findings highlight urgent need culturally tailored interventions evidence-based policies address disparities, reduce improve outcomes vulnerable populations globally.

Language: Английский

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Global Burden of type 2 diabetes in non-elderly individuals 1990 to 2021 and projections for 2050: a systematic analysis of the 2021 Global Burden of Disease

Diabetes & Metabolism, Journal Year: 2025, Volume and Issue: unknown, P. 101660 - 101660

Published: May 1, 2025

Language: Английский

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Global burden of lung cancer in women of childbearing age attributable to ambient particulate matter pollution: 1990–2021

Cancer Medicine, Journal Year: 2024, Volume and Issue: 13(18)

Published: Sept. 1, 2024

Abstract Background This study aimed to evaluate the global burden of lung cancer due ambient particulate matter (PM) pollution in women childbearing age from 1990 2021. Methods was a secondary analysis utilizing data Global Burden Disease (GBD) 2021, with focus on temporal trends attributable PM2.5 among age. Results In mortality and disability‐adjusted life years (DALYs) number were approximately 5205 247,211, respectively. The rate increased between age‐standardized (ASMR) increasing 0.22 (95% uncertainty interval [UI]; 0.13 0.33) 0.25 UI; 0.14 0.37; average annual percent change [AAPC] = 0.40) DALYs (ASDR) 10.39 5.96 15.72) 12.06 6.83 17.51; AAPC 0.41). middle sociodemographic index (SDI) region, East Asia, China had heaviest burden, while high SDI region showed highest decrease. ASMR ASDR exhibited an inverted U‐shaped relationship SDI. Conclusions From trend. Furthermore, attention should be paid China, as PM remains critical target for intervention.

Language: Английский

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Global Cancer Burden Attributable to Dietary Risks: Trends, Regional Disparities, and Future Projections (1990-2050)

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Abstract Cancer remains a leading global cause of death, with its burden increasingly shaped by demographic shifts and dietary factors. This study utilized the Global Burden Disease (GBD) 2021 database to evaluate cancer burdens attributable risks from 1990 2021, accounting for differences age, gender, region, socioeconomic level, projected trends through 2050 using Bayesian Age-Period-Cohort model. The disability-adjusted life years (DALYs) declined 302.48 189.62 per 100,000 population (AAPC: −1.49%) over three decades, yet disparities remain prominent across Socio-Demographic Index (SDI) regions. High-SDI countries, such as Luxembourg, achieved substantial reductions, while low-SDI nations like Lesotho Zimbabwe experienced rising burdens, driven inadequate quality limited health resources. Key risks, including low intake whole grains, milk, red meat, demonstrated improvement in high-income countries but worsening many low- middle-income Projections suggest continued decline factors 2050, regions benefiting most, Latin America, Caribbean, North Africa, Middle East may experience slower progress or transient increases. Additionally, poor practices is expected rise sharply among individuals aged 75 older, underscoring compounding effects aging populations. These findings highlight urgent need culturally tailored interventions evidence-based policies address disparities, reduce improve outcomes vulnerable populations globally.

Language: Английский

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