Cellular and Molecular Immunology,
Journal Year:
2022,
Volume and Issue:
19(3), P. 432 - 444
Published: Jan. 5, 2022
Tumour
growth
and
dissemination
is
largely
dependent
on
nutrient
availability.
It
has
recently
emerged
that
the
tumour
microenvironment
rich
in
a
diverse
array
of
lipids
increase
abundance
with
progression
play
role
promoting
metastasis.
Here,
we
describe
pro-tumorigenic
roles
lipid
uptake,
metabolism
synthesis
detail
therapeutic
potential
targeting
cancer.
Additionally,
highlight
new
insights
into
distinct
immunosuppressive
effects
microenvironment.
Lipids
threaten
an
anti-tumour
environment
whereby
metabolic
adaptation
to
linked
immune
dysfunction.
Finally,
differential
commondietary
cancer
which
may
uncover
for
specific
dietary
regimens
association
traditional
therapies.
Understanding
relationship
between
lipids,
tumour,
cells
important
context
obesity
reveal
possibility
harness
diet
treatment
cancers.
Cellular and Molecular Life Sciences,
Journal Year:
2018,
Volume and Issue:
75(18), P. 3313 - 3327
Published: June 23, 2018
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
currently
the
world's
most
common
disease,
estimated
to
affect
up
one-fourth
of
population.
Hallmarked
by
hepatic
steatosis,
NAFLD
associated
with
a
multitude
detrimental
effects
and
increased
mortality.
This
narrative
review
investigates
molecular
mechanisms
steatosis
in
NAFLD,
focusing
on
four
major
pathways
contributing
lipid
homeostasis
liver.
Hepatic
consequence
acquisition
exceeding
disposal,
i.e.,
uptake
acids
de
novo
lipogenesis
surpassing
acid
oxidation
export.
In
are
increased,
while
compensatory
enhancement
insufficient
normalizing
levels
may
even
promote
cellular
damage
progression
inducing
oxidative
stress,
especially
compromised
mitochondrial
function
peroxisomes
cytochromes.
While
export
initially
increases,
it
plateaus
decrease
progression,
sustaining
accumulation
lipids.
Fueled
lipo-apoptosis,
leads
systemic
metabolic
disarray
that
adversely
affects
multiple
organs,
placing
abnormal
metabolism
close
relation
many
current
life-style-related
diseases.
World Journal of Gastroenterology,
Journal Year:
2014,
Volume and Issue:
20(28), P. 9330 - 9337
Published: July 28, 2014
Laparoscopic
surgery
is
the
main
treatment
method
for
patients
with
gastrointestinal
malignant
tumors.
Although
laparoscopic
minimally
invasive,
its
tool
stimulation
and
pneumoperitoneum
pressure
often
cause
strong
stress
reactions
in
patients.
On
other
hand,
can
stronger
pain
patients,
compared
to
surgeries.
Transversus
abdominis
plane
block
(TAPB)
effectively
inhibit
transmission
of
nerve
impulses
caused
by
surgical
stimulation,
alleviate
patient
pain,
thus
reactions.
Remazolam
an
acting,
safe,
effective
sedative,
which
has
little
effect
on
hemodynamics
suitable
most
TAPB
combined
remazolam
reduce
dosage
total
anesthetic
drugs,
adverse
reactions,
facilitate
rapid
postoperative
recovery
Nutrients,
Journal Year:
2015,
Volume and Issue:
7(11), P. 9453 - 9474
Published: Nov. 13, 2015
Excessive
accumulation
of
lipids
can
lead
to
lipotoxicity,
cell
dysfunction
and
alteration
in
metabolic
pathways,
both
adipose
tissue
peripheral
organs,
like
liver,
heart,
pancreas
muscle.
This
is
now
a
recognized
risk
factor
for
the
development
disorders,
such
as
obesity,
diabetes,
fatty
liver
disease
(NAFLD),
cardiovascular
diseases
(CVD)
hepatocellular
carcinoma
(HCC).
The
causes
lipotoxicity
are
not
only
high
fat
diet
but
also
excessive
lipolysis,
adipogenesis
insulin
resistance.
aims
this
review
investigate
subtle
balances
that
underlie
lipolytic,
lipogenic
oxidative
evaluate
critical
points
complexities
these
processes
better
understand
which
derangements
resulting
from
their
imbalance,
type
2
diabetes
non
alcoholic
disease.
Clinical and Experimental Gastroenterology,
Journal Year:
2014,
Volume and Issue:
unknown, P. 221 - 221
Published: July 1, 2014
Abstract:
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
a
clinicopathological
change
characterized
by
the
accumulation
of
triglycerides
in
hepatocytes
and
has
frequently
been
associated
with
obesity,
type
2
diabetes
mellitus,
hyperlipidemia,
insulin
resistance.
It
an
increasingly
recognized
condition
that
become
most
common
disorder
developed
countries,
affecting
over
one-third
population
increased
cardiovascular-
liver-related
mortality.
NAFLD
spectrum
disorders,
beginning
as
simple
steatosis.
In
about
15%
all
cases,
steatosis
can
evolve
into
non-alcoholic
steatohepatitis,
medley
inflammation,
hepatocellular
injury,
fibrosis,
often
resulting
cirrhosis
even
cancer.
However,
molecular
mechanism
underlying
progression
not
completely
understood.
Its
pathogenesis
interpreted
"double-hit"
hypothesis.
The
primary
insult
or
"first
hit"
includes
lipid
liver,
followed
"second
which
proinflammatory
mediators
induce
fibrosis.
Nowadays,
more
complex
model
suggests
acids
(FAs)
their
metabolites
may
be
true
lipotoxic
agents
contribute
to
progression;
multiple
parallel
hits
hypothesis
also
suggested.
patients,
resistance
leads
hepatic
via
mechanisms.
Despite
excess
FAs
NAFLD,
it
described
only
de
novo
FA
synthesis
increased,
but
are
taken
up
from
serum.
Furthermore,
decrease
mitochondrial
oxidation
secretion
very-low-density
lipoproteins
reported.
This
review
discusses
mechanisms
underlie
pathophysiological
changes
metabolism
NAFLD.
Keywords:
disease,
pathways,
resistance,
acid
AJP Gastrointestinal and Liver Physiology,
Journal Year:
2020,
Volume and Issue:
318(3), P. G554 - G573
Published: Jan. 27, 2020
Bile
acid
synthesis
is
the
most
significant
pathway
for
catabolism
of
cholesterol
and
maintenance
whole
body
homeostasis.
acids
are
physiological
detergents
that
absorb,
distribute,
metabolize,
excrete
nutrients,
drugs,
xenobiotics.
also
signal
molecules
metabolic
integrators
activate
nuclear
farnesoid
X
receptor
(FXR)
membrane
Takeda
G
protein-coupled
5
(TGR5;
i.e.,
bile
1)
to
regulate
glucose,
lipid,
energy
metabolism.
The
gut-to-liver
axis
plays
a
critical
role
in
transformation
primary
secondary
acids,
regulation
maintain
composition
within
pool,
homeostasis
prevent
hyperglycemia,
dyslipidemia,
obesity,
diabetes.
High-fat
high-calorie
diets,
dysbiosis,
alcohol,
disruption
sleep
circadian
rhythms
cause
diseases,
including
alcoholic
nonalcoholic
fatty
liver
diabetes,
cardiovascular
disease.
acid-based
drugs
target
receptors
being
developed
treatment
diseases
liver.
