Echinacoside: A promising active natural products and pharmacological agents DOI Creative Commons
Wang Wang, Shujun Jiang, Yang Zhao

et al.

Pharmacological Research, Journal Year: 2023, Volume and Issue: 197, P. 106951 - 106951

Published: Oct. 5, 2023

Echinacoside, a natural phenylethanoid glycoside, was discovered and isolated from the garden plant Echinacea angustifolia DC., belonging to Compositae family, approximately sixty years ago. Extensive investigations have revealed that it possesses wide array of pharmacologically beneficial activities for human health, particularly notable its neuroprotective anticancer activity. Several crucial concerns surfaced, encompassing recognition active metabolites exhibited inadequate bioavailability in their prototype form, establishment precise molecular signal pathways or targets associated with aforementioned effects echinacoside, scarcity dependable clinical trials. Hence, question remains unanswered as whether scientific research can effectively utilize this compound. To support future studies on product, is imperative provide systematic overview insights into potential prospects. The current review provides comprehensive analysis existing knowledge distribution, structural diversity metabolism, diverse therapeutic applications, improvement echinacoside utilization.

Language: Английский

Macrophage Polarization and Its Role in Liver Disease DOI Creative Commons
Cheng Wang, Cheng Ma, Lihong Gong

et al.

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: Dec. 14, 2021

Macrophages are important immune cells in innate immunity, and have remarkable heterogeneity polarization. Under pathological conditions, addition to the resident macrophages, other macrophages also recruited diseased tissues, polarize various phenotypes (mainly M1 M2) under stimulation of factors microenvironment, thus playing different roles functions. Liver diseases hepatic changes caused by a variety pathogenic (viruses, alcohol, drugs, etc.), including acute liver injury, viral hepatitis, alcoholic disease, metabolic-associated fatty fibrosis, hepatocellular carcinoma. Recent studies shown that macrophage polarization plays an role initiation development diseases. However, because both pathogenesis complex, mechanism need be further clarified. Therefore, origin mechanisms reviewed first this paper. It is found involves several molecular mechanisms, mainly TLR4/NF-κB, JAK/STATs, TGF-β/Smads, PPARγ, Notch, miRNA signaling pathways. In addition, paper expounds diseases, which aims provide references for research contributing therapeutic strategy ameliorating modulating

Language: Английский

Citations

364
MAFLD and risk of CKD DOI Open Access
Dan‐Qin Sun, Yan Jin, Ting-Yao Wang

et al.

Metabolism, Journal Year: 2020, Volume and Issue: 115, P. 154433 - 154433

Published: Nov. 16, 2020

Language: Английский

Citations

251
Microbiota and Fatty Liver Disease—the Known, the Unknown, and the Future DOI Creative Commons
Sonja Lang, Bernd Schnabl

Cell Host & Microbe, Journal Year: 2020, Volume and Issue: 28(2), P. 233 - 244

Published: Aug. 1, 2020

Language: Английский

Citations

175
Curcumae rhizoma and its major constituents against hepatobiliary disease: Pharmacotherapeutic properties and potential clinical applications DOI

Tianhui Gao,

Wan Liao,

Li-Ting Lin

et al.

Phytomedicine, Journal Year: 2022, Volume and Issue: 102, P. 154090 - 154090

Published: March 31, 2022

Language: Английский

Citations

110
Prevalence of Liver Steatosis and Fibrosis in the General Population and Various High-Risk Populations: A Nationwide Study With 5.7 Million Adults in China DOI Creative Commons
Sailimai Man, Yuhan Deng, Yuan Ma

et al.

Gastroenterology, Journal Year: 2023, Volume and Issue: 165(4), P. 1025 - 1040

Published: June 26, 2023

This study aimed to estimate the prevalence of liver steatosis and fibrosis in general population populations with potential risk factors China, so as inform policies for screening management fatty disease high-risk populations.

Language: Английский

Citations

89
Liver diseases: epidemiology, causes, trends and predictions DOI Creative Commons

Can Gan,

Yuan Yuan, Haiyuan Shen

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 4, 2025

Abstract As a highly complex organ with digestive, endocrine, and immune-regulatory functions, the liver is pivotal in maintaining physiological homeostasis through its roles metabolism, detoxification, immune response. Various factors including viruses, alcohol, metabolites, toxins, other pathogenic agents can compromise function, leading to acute or chronic injury that may progress end-stage diseases. While sharing common features, diseases exhibit distinct pathophysiological, clinical, therapeutic profiles. Currently, contribute approximately 2 million deaths globally each year, imposing significant economic social burdens worldwide. However, there no cure for many kinds of diseases, partly due lack thorough understanding development these Therefore, this review provides comprehensive examination epidemiology characteristics covering spectrum from conditions manifestations. We also highlight multifaceted mechanisms underlying initiation progression spanning molecular cellular levels networks. Additionally, offers updates on innovative diagnostic techniques, current treatments, potential targets presently under clinical evaluation. Recent advances pathogenesis hold critical implications translational value novel strategies.

Language: Английский

Citations

3
Aldehyde Dehydrogenase, Liver Disease and Cancer DOI Creative Commons
Wenjun Wang,

Chunguang Wang,

Hongxin Xu

et al.

International Journal of Biological Sciences, Journal Year: 2020, Volume and Issue: 16(6), P. 921 - 934

Published: Jan. 1, 2020

Acetaldehyde dehydrogenase 2 (ALDH2) is the key enzyme responsible for metabolism of alcohol metabolite acetaldehyde in liver.In addition to conversion molecule, ALDH also involved other cellular functions.Recently, many studies have investigated involvement expression viral hepatitis, alcoholic liver disease (ALD), non-alcoholic fatty (NAFLD), fibrosis, and cancer.Notably, ALDH2 has been linked with cancer risk, as well pathogenesis prognosis, emerged a promising therapeutic target.Of note, approximately 8% world's population, 30-40% population East Asia carry an inactive gene.This review summarizes new progress understanding tissue-specific by association gene polymorphisms cancer.New research directions emerging field are briefly discussed.

Language: Английский

Citations

105
Current Advances on 3D‐Bioprinted Liver Tissue Models DOI
Liang Ma, Yutong Wu, Yuting Li

et al.

Advanced Healthcare Materials, Journal Year: 2020, Volume and Issue: 9(24)

Published: Oct. 19, 2020

Abstract The liver, the largest gland in human body, plays a key role metabolism, bile production, detoxification, and water electrolyte regulation. toxins or drugs that gastrointestinal system absorbs reach liver first before entering bloodstream. Liver disease is one of leading causes death worldwide. Therefore, an vitro tissue model reproduces main functions can be reliable platform for investigating diseases developing new drugs. In addition, limitations traditional, planar monolayer cell cultures animal tests evaluating toxicity efficacy drug candidates overcome. Currently, newly emerging 3D bioprinting technologies have ability to construct models both static scaffolds dynamic liver‐on‐chip manners. This review mainly focuses on construction applications based bioprinting. Special attention given strategies bioinks constructing including sources hydrogel selection. advantages major challenges future perspectives are discussed, paving way next generation models.

Language: Английский

Citations

99
The Chinese Society of Hepatology position statement on the redefinition of fatty liver disease DOI Open Access
Yuemin Nan, Jihong An, Jianfeng Bao

et al.

Journal of Hepatology, Journal Year: 2021, Volume and Issue: 75(2), P. 454 - 461

Published: May 19, 2021

Language: Английский

Citations

98
Prevalence of comorbidity in Chinese patients with COVID-19: systematic review and meta-analysis of risk factors DOI Creative Commons

Tingxuan Yin,

Yuanjun Li, Ying Ying

et al.

BMC Infectious Diseases, Journal Year: 2021, Volume and Issue: 21(1)

Published: Feb. 22, 2021

Abstract Background Coronavirus disease 2019 (COVID-19) is an infectious characterized by cough, fever, and fatigue 20% of cases will develop into severe conditions resulting from acute lung injury with the manifestation respiratory distress syndrome (ARDS) that accounts for more than 50% mortality. Currently, it has been reported some comorbidities are linked increased rate severity mortality among COVID-19 patients. To assess role comorbidity in progression, we performed a systematic review meta-analysis on relationship 8 different underlying diseases. Methods PubMed, Web Science, CNKI were searched articles investigating prevalence non-severe A total 41 studies comprising 12,526 patients included. Results Prevalence commodities was lower general population such as hypertension (19% vs 23.2%), diabetes (9% 10.9%), chronic kidney (CKD) (2% 9.5%), liver diseases (CLD) (3% 24.8%) obstructive pulmonary (COPD) 8.6%), while others including cancer (1% 0.6%), cardiovascular (6% 1.8%) cerebrovascular 0.9%) exhibited greater percentage COVID-19. Cerebrovascular (OR = 3.70, 95%CI 2.51–5.45) found to be strongest risk factor exacerbation, followed CKD 3.60, 2.18–5.94), COPD 3.14, 95% CI 2.35–4.19), 2.76, 2.18–3.49), malignancy 2.63, 1.75–3.95), 2.49, 2.10–2.96) 2.13, 1.81–2.51). We no correlation between CLD 1.32, 0.96–1.82). Conclusion The impact all eight deterioration seemed higher outside Hubei. Based comorbidities, tend at developing poor outcomes varying degree. Thus, tailored infection prevention monitoring treatment strategies targeting these high-risk subgroups might improve prognosis during pandemic.

Language: Английский

Citations

95