Exploring the synthesis, molecular structure and biological activities of novel Bis-Schiff base derivatives: A combined theoretical and experimental approach

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1306, P. 137828 - 137828

Published: Feb. 17, 2024

Language: Английский

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Regulation of ferroptosis by PI3K/Akt signaling pathway: a promising therapeutic axis in cancer

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: March 18, 2024

The global challenge posed by cancer, marked rising incidence and mortality rates, underscores the urgency for innovative therapeutic approaches. PI3K/Akt signaling pathway, frequently amplified in various cancers, is central regulating essential cellular processes. Its dysregulation, often stemming from genetic mutations, significantly contributes to cancer initiation, progression, resistance therapy. Concurrently, ferroptosis, a recently discovered form of regulated cell death characterized iron-dependent processes lipid reactive oxygen species buildup, holds implications diseases, including cancer. Exploring interplay between dysregulated pathway ferroptosis unveils potential insights into molecular mechanisms driving or inhibiting ferroptotic cells. Evidence suggests that may sensitize cells induction, offering promising strategy overcome drug resistance. This review aims provide comprehensive exploration this interplay, shedding light on disrupting enhance as an alternative route inducing improving treatment outcomes.

Language: Английский

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Non-coding RNA mediated regulation of PI3K/Akt pathway in hepatocellular carcinoma: Therapeutic perspectives

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 258, P. 155303 - 155303

Published: April 28, 2024

Language: Английский

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From nature to nanomedicine: bioengineered metallic nanoparticles bridge the gap for medical applications

Discover Nano, Journal Year: 2024, Volume and Issue: 19(1)

Published: May 9, 2024

Abstract The escalating global challenge of antimicrobial resistance demands innovative approaches. This review delves into the current status and future prospects bioengineered metallic nanoparticles derived from natural sources as potent agents. unique attributes abundance resources have sparked a burgeoning field research in combating microbial infections. A systematic literature was conducted, encompassing wide range studies investigating synthesis, characterization, mechanisms nanoparticles. Databases such PubMed, Scopus, Web Science, ScienceDirect, Springer, Taylor & Francis online OpenAthen were extensively searched to compile comprehensive overview topic. synthesis methods, including green sustainable approaches, examined, diverse biological used nanoparticle fabrication. amalgamation products has yielded promising Their multifaceted mechanisms, membrane disruption, oxidative stress induction, enzyme inhibition, render them effective against various pathogens, drug-resistant strains. Moreover, potential for targeted drug delivery systems using these opened new avenues personalized medicine. Bioengineered represent dynamic frontier battle underscores their remarkable efficacy action. Future are bright, with opportunities scalability cost-effectiveness through methods. However, addressing toxicity, regulatory hurdles, environmental considerations remains crucial. In conclusion, this highlights evolving landscape nanoparticles, offering valuable insights revolutionize therapy future. Graphical

Language: Английский

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Preliminary Data on Silybum marianum Metabolites: Comprehensive Characterization, Antioxidant, Antidiabetic, Antimicrobial Activities, LC-MS/MS Profiling, and Predicted ADMET Analysis

Metabolites, Journal Year: 2025, Volume and Issue: 15(1), P. 13 - 13

Published: Jan. 3, 2025

Silybum marianum extract, obtained via microwave-enhanced extraction, was evaluated for its antioxidant, antidiabetic, and antimicrobial activities to explore therapeutic potential. The extraction performed using techniques, LC-MS/MS employed profile the metabolites in extract. Total phenolic flavonoid contents were quantified spectrophotometric methods. Antioxidant activity assessed DPPH, ABTS, CUPRAC, Phenanthroline, FRAP assays. Enzyme inhibition assays conducted evaluate antidiabetic against α-glucosidase α-amylase. Antimicrobial determined disc diffusion method, silico ADMET drug-likeness analyses key metabolites. extract contained 251.2 ± 1.2 mg GAE/g of total phenolics 125.1 1.6 QE/g flavonoids, with 33 identified, including acids, tannins, flavolignans. Strong antioxidant observed, IC50 values 19.2 2.3 μg/mL (DPPH), 7.2 1.7 (ABTS), 22.2 (CUPRAC), 35.2 1.8 (Phenanthroline), 24.1 (FRAP). Antidiabetic effects significant, 18.1 (α-glucosidase) 26.5 1.3 (α-amylase). demonstrated zones 8.9 1.1 mm (Bacillus subtilis), 12.6 (Escherichia coli), 8.2 (Fusarium oxysporum), 9.2 (Aspergillus niger). In showed high absorption, favorable metabolism excretion, minimal toxicity, no hERG channel or hepatotoxicity. comprehensive results highlight significant S. suggesting potential preventive applications.

Language: Английский

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Targeted modulation of gut microbiota by traditional Chinese medicine and natural products for liver disease therapy

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 2, 2023

The gut microbiota not only constitutes intestinal microenvironment homeostasis and human health but also exerts indispensable roles in the occurrence progression of multiple liver diseases, including alcohol-related disease, nonalcoholic fatty autoimmune disease cancer. Given therapeutic status these their prevention early therapy are crucial, detailed mechanism urgently needs to be explored. Meanwhile, studies have shown that various traditional Chinese medicines, such as Si Miao Formula, Jiangzhi Granules, Liushen Capsules, Chaihu-Shugan Power, Cassiae Semen Gynostemma, well some natural products, Costunolide, Coprinus comatus polysaccharide, Antarctic krill oil, Oridonin Berberine, can repair injury, improve liver, regulate immunity, even inhibit cancer through targets, links, pathways. Intriguingly, aforementioned effects demonstrated by medicines products been closely related microbiota, directly driving strategy one breakthroughs treatment diseases. Based on this, this review comprehensively summarizes discusses characteristics, functions potential mechanisms targeting during treatment. Research regulatory medicine provides novel insights significant references for developing strategies. In parallel, explorations will enhance comprehension modulating treatment, thus facilitating clinical investigation application.

Language: Английский

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Potential roles and molecular mechanisms of bioactive ingredients in Curcumae Rhizoma against breast cancer

Phytomedicine, Journal Year: 2023, Volume and Issue: 114, P. 154810 - 154810

Published: April 6, 2023

Language: Английский

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Phlorizin, an Important Glucoside: Research Progress on Its Biological Activity and Mechanism

Molecules, Journal Year: 2024, Volume and Issue: 29(3), P. 741 - 741

Published: Feb. 5, 2024

Phlorizin, as a flavonoid from wide range of sources, is gradually becoming known for its biological activity. Phlorizin can exert antioxidant effects by regulating the IL-1β/IKB-α/NF-KB signaling pathway. At same time, it exerts antibacterial activity reducing intracellular DNA agglutination, protein and energy synthesis, destroying metabolism. In addition, phlorizin also has various pharmacological such antiviral, antidiabetic, antitumor, hepatoprotective effects. Based on domestic foreign research reports, this article reviews plant extraction, activities phlorizin, providing reference improving clinical application phlorizin.

Language: Английский

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Recent advances in natural nanoclay for diagnosis and therapy of cancer: A review

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 235, P. 113768 - 113768

Published: Jan. 26, 2024

Language: Английский

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Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches

Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 2485 - 2529

Published: June 1, 2024

Abstract: Ferroptosis, a unique form of programmed cell death, is initiated by an excess iron accumulation and lipid peroxidation-induced damage. There growing body evidence indicating that ferroptosis plays critical role in the advancement tumors. The increased metabolic activity higher levels tumor cells make them particularly vulnerable to ferroptosis. As result, targeted induction becoming increasingly promising approach for cancer treatment. This review offers overview regulatory mechanisms ferroptosis, delves into mechanism action traditional small molecule inducers their effects on various In addition, latest progress inducing using new means such as proteolysis-targeting chimeras (PROTACs), photodynamic therapy (PDT), sonodynamic (SDT) nanomaterials summarized. Finally, this discusses challenges opportunities development ferroptosis-inducing agents, focusing discovering targets, improving selectivity, reducing toxic side effects. Keywords: inducers, molecules, PROTACs, PDT, SDT,

Language: Английский

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