Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Journal of Hepatology, Journal Year: 2023, Volume and Issue: 79(2), P. 552 - 566
Published: April 14, 2023
Language: Английский
Citations
158
Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)
Published: Dec. 6, 2023
Gut-liver-brain axis is a three-way highway of information interaction system among the gastrointestinal tract, liver, and nervous systems. In past few decades, breakthrough progress has been made in gut liver brain axis, mainly through understanding its formation mechanism increasing treatment strategies. this review, we discuss various complex networks including barrier permeability, hormones, microbial metabolites, vagus nerve, neurotransmitters, immunity, toxic β-amyloid (Aβ) metabolism, epigenetic regulation gut-liver-brain axis. Some therapies containing antibiotics, probiotics, prebiotics, synbiotics, fecal microbiota transplantation (FMT), polyphenols, low FODMAP diet nanotechnology application regulate Besides, some special treatments targeting gut-liver include farnesoid X receptor (FXR) agonists, takeda G protein-coupled 5 (TGR5) glucagon-like peptide-1 (GLP-1) antagonists fibroblast growth factor 19 (FGF19) analogs. Targeting gut-brain embraces cognitive behavioral therapy (CBT), antidepressants tryptophan metabolism-related therapies. liver-brain contains Aβ future, better interactions will promote development novel preventative strategies discovery precise therapeutic targets multiple diseases.
Language: Английский
Citations
86
Seminars in Immunology, Journal Year: 2024, Volume and Issue: 71, P. 101859 - 101859
Published: Jan. 21, 2024
Language: Английский
Citations
19
Gastroenterology, Journal Year: 2020, Volume and Issue: 165(1), P. 5 - 10
Published: May 18, 2020
Language: Английский
Citations
71
Gut Microbes, Journal Year: 2023, Volume and Issue: 15(2)
Published: Aug. 24, 2023
Hepatocellular carcinoma (HCC) has been linked to the gut microbiota, with recent studies revealing potential of gut-generated responses influence several arms immune relevant HCC formation. The pro- or anti-tumor effects specific bacterial strains microbiota-related metabolites, such as bile acids and short-chain fatty acids, have highlighted in many human animal studies. critical role microbiota development spurred interest modulating through dietary interventions, probiotics, fecal transplantation a strategy improve liver cancer outcomes. Encouragingly, preclinical clinical demonstrated that modulation can ameliorate function, reduce inflammation, inhibit tumor growth, underscoring this approach As research continues unravel complex dynamic mechanisms underlying gut-liver axis, safe effective interventions target pathway for prevention treatment appears be on horizon, heralding significant advance our ongoing efforts combat devastating disease.
Language: Английский
Citations
35
Gut Microbes, Journal Year: 2023, Volume and Issue: 15(1)
Published: June 26, 2023
Humans possess abundant amounts of microorganisms, including bacteria, fungi, viruses, and archaea, in their gut. Patients with nonalcoholic fatty liver disease (NAFLD) exhibit alterations gut microbiome an impaired barrier function. Preclinical studies emphasize the significance pathogenesis NAFLD. In this overview, we explore how adjusting could serve as innovative therapeutic strategy for We provide a summary current information on untargeted techniques such probiotics fecal microbiota transplantation, well targeted microbiome-focused therapies engineered prebiotics, postbiotics, phages treatment
Language: Английский
Citations
31
Research, Journal Year: 2023, Volume and Issue: 6
Published: Jan. 1, 2023
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Citations
24
Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)
Published: Feb. 27, 2024
The gut microbiome is known as the tenth system of human body that plays a vital role in intersection between health and disease. considerable inter-individual variability microbiota poses both challenges great prospects promoting precision medicine cardiovascular diseases (CVDs). In this review, based on development, evolution, influencing factors full life circle, we summarized recent advances characteristic alteration CVDs throughout different stages, depicted their pathological links mechanism, well highlight achievements targeting prevention, diagnosis treatment. Personalized strategies could be tailored according to characteristics including microbiota-blood metabolites combined prediction diagnosis, dietary interventions, lifestyle improvements, probiotic or prebiotic supplements. However, fulfill promise lifelong health, more mechanism studies should progress from correlation causality decipher novel mechanisms linking specific microbes CVDs. It also promising use burgeoning artificial intelligence machine learning target for developing screening new therapeutic interventions.
Language: Английский
Citations
10
Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15
Published: March 14, 2024
The gut-liver axis has emerged as a focal point in chronic liver disorders, prompting more research into the role of gut microbiota cirrhosis. In individuals with cirrhosis, changes structure and function are closely tied to clinical prognosis. However, there is scarcity bibliometric evaluations conducted this particular field.
Language: Английский
Citations
9
Nano Today, Journal Year: 2023, Volume and Issue: 50, P. 101876 - 101876
Published: May 24, 2023
Language: Английский
Citations
22