Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
JHEP Reports, Journal Year: 2023, Volume and Issue: 5(12), P. 100909 - 100909
Published: Sept. 23, 2023
Phage therapy has been overshadowed by antibiotics for decades. However, it is being revisited as a powerful approach against antimicrobial-resistant bacteria. As bacterial microbiota have mechanistically linked to gastrointestinal and liver diseases, precise editing of the gut via selective bactericidal action phages prompted renewed interest in phage therapy. In this review, we summarise basic virological properties latest findings on composition intestinal phageome changes associated with diseases. We also review preclinical clinical studies assessing treatment well future prospects challenges.
Language: Английский
Citations
19
Microorganisms, Journal Year: 2024, Volume and Issue: 12(8), P. 1627 - 1627
Published: Aug. 9, 2024
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Citations
5
Journal of Hepatology, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 1, 2024
Language: Английский
Citations
5
Cells, Journal Year: 2022, Volume and Issue: 11(17), P. 2718 - 2718
Published: Aug. 31, 2022
Numerous studies show a modification of the gut microbiota in patients with obesity or diabetes. Animal have also shown causal role liver metabolic disorders including steatosis whereas human situation is less clear. Patients dysfunction associated fatty disease (MAFLD) their composition but changes are not fully characterized. The absence consensus on precise signature probably due to heterogeneity, possible concomitant medications and different selection evaluation criteria. most consistent were increased relative abundance Proteobacteria, Enterobacteriaceae Escherichia species decreased Coprococcus Eubacterium. Possible mechanisms linking MAFLD intestinal permeability translocation microbial products into portal circulation, bile acids production metabolites such as ethanol, short chain amino acid derivatives able modulate metabolism inflammation. Several interventional exist that attempt by administering antibiotics, probiotics, prebiotics, synbiotics, postbiotics fecal transplantation. In conclusion, there both gaps hopes concerning interest microbiome for diagnosis purposes new therapeutic developments often tested small size cohorts.
Language: Английский
Citations
20
Frontiers in Medicine, Journal Year: 2022, Volume and Issue: 9
Published: July 22, 2022
Alcoholic liver disease (ALD) involves a wide spectrum of diseases, including asymptomatic hepatic steatosis, alcoholic hepatitis, fibrosis, and cirrhosis, which leads to morbidity mortality is responsible for 0.9% global deaths. Alcohol consumption induces bacterial translocation alteration the gut microbiota composition. These changes in aggravate inflammation fibrosis. Alteration weakened barrier host immunity metabolic function, especially related bile acid metabolism. Modulation treatment ALD has been studied using probiotics, prebiotics, synbiotics, fecal microbial transplantation with meaningful results. In this review, we focused on interaction between alcohol dysbiosis ALD. Additionally, approaches dysbiosis, such as abstinence, diet, pro-, pre-, antibiotics, transplantation, are covered here under However, further research through human clinical trials warranted evaluate appropriate microbiota-modulating agents each condition
Language: Английский
Citations
19
Clinics in Liver Disease, Journal Year: 2023, Volume and Issue: 27(2), P. 535 - 551
Published: Feb. 26, 2023
Language: Английский
Citations
12
Liver International, Journal Year: 2023, Volume and Issue: unknown
Published: Feb. 17, 2023
Abstract Acute‐on‐chronic liver failure (ACLF) is a syndrome that develops in approximately 30% of patients hospitalised with cirrhosis and characterised by an acute decompensation function associated extra‐hepatic organ failures high short‐term mortality. At present, no specific therapies are available for ACLF, current management limited to treatment the precipitating event support. Given prevalence mortality this severe disease, there urgent need targeted treatments. There increasing evidence important role played systemic inflammation immune dysfunction pathophysiology ACLF better understanding these processes resulting new therapeutic targets. The aim review present overview ongoing studies potentially promising how they could be utilised ACLF.
Language: Английский
Citations
11
Biomedicines, Journal Year: 2024, Volume and Issue: 12(3), P. 550 - 550
Published: Feb. 29, 2024
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are closely related conditions that have become more prevalent globally. This review examines the intricate interplay between microbiome dysbiosis mitochondrial dysfunction in development of NAFLD NASH. The combination these two factors creates a synergistic situation referred to as “double trouble”, which promotes accumulation lipids subsequent progression from simple steatosis inflammation (NASH). Microbiome dysbiosis, characterized by changes composition gut microbes increased intestinal permeability, contributes movement bacterial products into liver. It triggers metabolic disturbances has anti-inflammatory effects. Understanding complex relationship NASH is crucial for advancing innovative therapeutic approaches target underlying mechanisms.
Language: Английский
Citations
4
Updates in Surgery, Journal Year: 2024, Volume and Issue: unknown
Published: June 25, 2024
Abstract Bacterial infections pose a life-threatening complication in patients with decompensated liver cirrhosis and acute-on-chronic failure. An increasing prevalence of caused by multidrug-resistant organisms (MDROs) has been observed these patients, significantly impacting prognosis. A growing body evidence identified the most common risk factors for such infections, enabling development preventive strategies therapeutic interventions. MDRO may also occur after transplantation (most commonly early post-operative phase), affecting both graft patient survival. This review provides an overview before transplantation, discussing epidemiological aspects, factors, prevention strategies, novel approaches. Furthermore, it examines implications context prioritizing severe as those
Language: Английский
Citations
4
Accounts of Chemical Research, Journal Year: 2024, Volume and Issue: 57(16), P. 2358 - 2371
Published: Aug. 2, 2024
ConspectusCells, particularly living cells, serve as natural carriers of bioactive substances. Their inherent low immunogenicity and multifunctionality have garnered significant attention in the realm disease treatment applications, specifically within domains cancer immunotherapy regenerative tissue repair. Nevertheless, several prominent challenges impede their swift translation into clinical including obstacles related to large-scale production feasibility high utilization costs. To address these issues comprehensively, researchers proposed notion bionic cells that are synthetically generated through chemical or biosynthetic means emulate cellular functions behaviors. However, artificial cell strategies encounter difficulties fully replicating intricate functionalities exhibited by while also grappling with complexities associated design implementation for purposes. The convergence disciplines has facilitated reform a range approaches, chemical-, biological-, genetic-, materials-based methods. These techniques can be employed impart specific enhance efficacy therapy. For example, engineered gene transduction, surface modifications, endocytosis drugs delivery systems, membrane fusion. concept presents promising avenue enhancing control over thereby therapeutic concurrently mitigating toxic side effects ultimately facilitating realization precision medicine.In this Account, we present comprehensive overview our recent research advancements field cells. Our work involves application biological engineering manipulate endogenous therapeutics drug instance, avoid laborious process isolating, modifying, expanding
Language: Английский
Citations
4