Current Opinion in Gastroenterology, Journal Year: 2023, Volume and Issue: 39(3), P. 169 - 174
Published: March 28, 2023
Infection with hepatitis E virus (HEV) is a global health concern, yet clinically underdiagnosed cause of acute and chronic hepatitis. The WHO estimates that 20 million people are infected HEV annually, the epidemiology, diagnosis prevention remain elusive in many clinical settings.
Language: Английский
Hepatology Research, Journal Year: 2025, Volume and Issue: unknown
Published: March 12, 2025
Abstract Aim To estimate the weighted prevalence of hepatitis E virus (HEV) antibodies and risk factors among pregnant women in Burkina Faso to evaluate efficiency dried blood spots (DBS) detecting HEV antibodies. Methods We first evaluated DBS by comparing 62 with matched serum samples using recomWell IgG IgM kits (Mikrogen Diagnostik). Anti‐HEV immunoglobulin G (IgG) M (IgM) were identified 491 collected from kits. RNA was tested nested polymerase chain reaction HEV‐antibodies positive. The survey‐weighted method applied for calculations analysis. Results detection anti‐HEV revealed a sensitivity 96.7% 76.7% specificity 100% 93.8% compared samples, respectively. Among tested, 18.6%, 2.5%, no detected. A significant age‐related increase observed ( p < 0.001), while found IgM‐positivity = 0.1451). Multiparity significantly associated IgG‐positivity, aged 25–34 years at higher IgM‐positivity. Conclusion This study that is reliable alternative seroepidemiological studies, especially resource‐limited settings, although further investigation needed detection. 18.6% highlighting ongoing burden infection, particularly high‐risk groups like rural Faso.
Language: Английский
Citations
0
Frontiers in Public Health, Journal Year: 2023, Volume and Issue: 11
Published: Sept. 7, 2023
Several studies have reported on hepatitis E virus (HEV) prevalence in various regions of China, but the results vary widely. Herein, we conducted a systematic review and meta-analysis to assess seroprevalence, RNA-positive rate, genotype distribution HEV its risk factors.We included 208 related involving 1,785,569 participants published between 1997 2022. Random-effects models were used pool prevalence, subgroup analyses by population, gender, age, study period, regions, rural-urban distribution. The meta regression pooled odds ratios (OR) performed identify factors for infections.The anti-HEV IgG, IgM, Ag RNA detection rates China from 2022 23.17% [95% confidence interval (CI): 20.23-26.25], 0.73% (95% CI: 0.55-0.93), 0.12% 0.01-0.32), 6.55% 3.46-12.05), respectively. IgG seropositivity was higher occupational population (48.41%; 95% 40.02-56.85) older adult aged 50-59 years (40.87%; 31.95-50.11). dominant (GT) GT4. Notably, drinking non-tap water (OR = 1.82; 1.50-2.20), consumption raw or undercooked meat 1.47; 1.17-1.84), ethnic minorities 1.50; 1.29-1.73) seroprevalence.Overall, relatively high especially among adults, minorities, humans with exposure pigs. Thus, there is need preventive measures, including infection screening surveillance, health education, vaccine intervention high-risk areas populations.https://www.crd.york.ac.uk/prospero/, identifier CRD42023397036.
Language: Английский
Citations
11
WIREs Mechanisms of Disease, Journal Year: 2024, Volume and Issue: 16(3)
Published: Jan. 22, 2024
Abstract Liver disease represents a significant global burden, placing individuals at heightened risk of developing cirrhosis and liver cancer. Viral infections act as primary cause diseases on worldwide scale. Infections involving hepatitis viruses, notably B, C, E stand out the most prevalent contributors to acute chronic intrahepatic adverse outcome, although C virus (HCV) can be effectively cured with antiviral drugs, but no preventative vaccination developed. Hepatitis B (HBV) HCV lead both diseases, including hepatocellular carcinoma (HCC), which are principal causes morbidity mortality. Other such Epstein–Barr (EBV) cytomegalovirus (CMV), capable causing damage. Therefore, it is essential recognize that intricate interconnected processes. A profound understanding underlying relationship between proves pivotal in effective prevention, diagnosis, treatment these conditions. In this review, we delve into mechanisms by induce well explore pathogenesis, diseases. This article categorized under: Infectious Diseases > Biomedical Engineering
Language: Английский
Citations
4
Journal of Medical Virology, Journal Year: 2024, Volume and Issue: 96(6)
Published: June 1, 2024
Abstract Recently, hepatitis E virus (HEV, Paslahepevirus balayani ) particles were detected for the first time in ejaculate of two chronically infected patients. Since then, we have been able to detect HEV five further patients, and thus a total seven out nine (78%) men (age 36–67 years, median 56 years). In RNA concentration was more than 100‐fold higher compared serum, while viral load 10‐fold lower. However, it has remained unclear whether shed infectious, as previous cell culture model had failed demonstrate infectivity. current study, employed an optimized system based on overconfluent PLC/PRF/5 cells investigate infectivity from other body fluids. With this approach, show that several patients infectious. replicated high loads 1e9 copies per ml. This indicates HEV‐positive could bear risk infection sexual partners.
Language: Английский
Citations
4
Journal of General Virology, Journal Year: 2025, Volume and Issue: 106(2)
Published: Feb. 12, 2025
Clinical and experimental studies have advanced our understanding of hepatitis E virus (HEV) infection; however, translating the findings to improve prevention clinical outcomes remains challenging. Phylogenetic analyses HEV show inconsistencies due variations in nucleotide regions studied. This study examined specific facilitate comprehensive molecular phylogenetic by examining complete genome commonly studied partial regions. We compared topological similarities between trees evaluated evolutionary divergence using base substitutions pairwise distances. The hypervariable region (HVR) showed closest topology (Robinson–Foulds, Jaccard Robinson–Foulds clustering information) a higher mutation rate, resulting longer branch lengths clearer genotypic distinctions. Pairwise analysis revealed greater intra- intergenotypic diversity HVR than other substitution rate suggest its key role genotype evolution. Classifying instead genomic can reveal subtypes that more accurately reflect genetic characteristics HEV. Future research could focus on HVRs better compare symptoms features
Language: Английский
Citations
0
Microorganisms, Journal Year: 2025, Volume and Issue: 13(2), P. 412 - 412
Published: Feb. 13, 2025
Background: Swine hepatitis E (HEV) is a zoonotic infectious disease caused by the swine virus (SHEV). Open reading frame 3 (ORF3) key virulence factor in HEV, playing crucial role release of viral particles, modulation host innate immune response, and regulation autophagy apoptosis, etc. However, its main function pathogenic mechanism remain incompletely understood. Results: In our study, adenoviruses ADV4-ORF3 ADV4-GFP were successfully constructed mediated overexpression enhanced green fluorescent protein (EGFP)-ORF3 EGFP HepG2 cells. A total 217 differentially expressed messenger RNAs (mRNAs) screened high-throughput sequencing, 27 statistically significant genes for further quantitative real-time reverse transcription (qRT-PCR) verification functional enrichment (Gene Ontology [GO] Kyoto Encyclopedia Genes Genomes [KEGG]). They are mainly involved six pathways: cellular response to unfolded protein, inflammatory cytokine activity, TNF signaling pathway, influenza A, pathways cancer. comparative analysis transcriptome mRNA expression profiles lncRNA results showed that mRNAs GPX1, MDM4, CLDN 39 transcripts overlapped have been identified. Conclusions: Eight differential genes, HSPA1A, HSPA1B, PLD3, RELA, GPI, SAMHD1, RPS6KA4, PIK3CB, verified. Comparing analyzing two sequencing methods indicated identified SHEV ORF3-expressing cells, which has laid genetic foundation physiological ORF3.
Language: Английский
Citations
0
Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: Feb. 17, 2025
The effectiveness of the hepatitis E vaccine in high-risk groups, such as chronic B (CHB) patients, remains understudied. A key clinical manifestation CHB is persistent positivity surface antigen (HBsAg). We conducted a test-negative design study involving 2,926 HBsAg-positive individuals (born 1941-1991; median age 49.0; male-to-female ratio 1.4), identified through surveillance system, part phase 3 trial (NCT01014845) recombinant HEV 239 (Hecolin). This system monitored suspected cases and performed diagnoses across 11 townships Dongtai, Jiangsu, China, from 2007 to 2017. Vaccine was assessed by comparing vaccination status between confirmed 96 2830 controls, using logistic regression adjusted for sex age. found that associated with reduced risk among individuals, an estimated 72.1% [95% confidence interval (CI) 11.2-91.2], 81.5% (95% CI 35.9-94.6) participants. Our findings show highly effective adults, supporting its future recommended use this population.
Language: Английский
Citations
0
Viruses, Journal Year: 2025, Volume and Issue: 17(3), P. 339 - 339
Published: Feb. 28, 2025
Hepatitis E virus (HEV) is a major zoonotic pathogen causing hepatitis E, with strains identified in various animal species, including pigs, wild boar, rabbits, deer, camels, and rats. These variants are capable of crossing species barriers infecting humans. HEV belongs to the family Hepeviridae, which has recently divided into two subfamilies: Orthohepevirinae Parahepevirinae, five genera: Paslahepevirus, Avihepevirus, Rocahepevirus, Chirohepevirus, Piscihepevirus. Recent advances high-throughput sequencing, particularly bat viromes, have revealed numerous HEV-related viruses, raising concerns about their potential. Bat-derived HEVs been classified genus includes three distinct species. In this study, we analyzed 64 chirohepevirus sequences from 22 across six families collected nine countries. Twelve represent complete or nearly viral genomes (>6410 nucleotides) containing characteristic open reading frames (ORFs). exhibited high sequence divergence (>25%) within respective host genera Phylogenetic analyses maximum likelihood methods at least seven subclades each potentially representing an independent Additionally, close phylogenetic relationship between hosts indicates pattern virus–host co-speciation. Our findings expand known diversity Hepeviridae provide new insights evolution bat-associated HEV. Continued surveillance will be essential for understanding its potential transmission public health risks.
Language: Английский
Citations
0
Infectious Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11
Published: Feb. 27, 2025
Background Hepatitis E virus (HEV) infection is endemic in China. However, there are scarce data of HEV among hospital attendees seeking medical treatment or examination for various reasons.
Language: Английский
Citations
0
Clinical Microbiology and Infection, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
0