Menstrual Changes Following COVID-19 Vaccination: A Cross-Sectional Study

Medicina, Journal Year: 2024, Volume and Issue: 60(2), P. 206 - 206

Published: Jan. 25, 2024

Background and Objectives: Menstrual changes, including altered cycle length bleeding patterns, have been reported following COVID-19 vaccination. This study aimed to determine the prevalence types of menstrual changes occurring after vaccination among female students staff at a university in Saudi Arabia. Materials Methods: A cross-sectional was conducted women aged 18–39 years who received least one dose vaccine. Eligible participants, staff, were recruited between May 2022 November 2022. Participants completed questionnaire detailing their sociodemographic characteristics, general medical reproductive history, characteristics before The various (cycle length, days, flow, mid-cycle spotting) calculated. demographic factors associated with analyzed using chi-squared tests. Results: 472 included participants had mean age 20.9 years, 95.3% unmarried. Changes by 54.7% respondents overall. most common change followed number menstruation days flow. not age, BMI, occupation, marital status, or history. intermenstrual more frequently third Pfizer vaccine compared Moderna (p = 0.014). Conclusions: More than half vaccination, being common. potential underlying mechanisms implications these alterations require further investigation. These findings provide evidence side effects vaccines

Language: Английский

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Menstrual disorders following COVID-19 vaccination: a review using a systematic search

Frontiers in Drug Safety and Regulation, Journal Year: 2024, Volume and Issue: 4

Published: Jan. 31, 2024

Introduction: Menstrual disorders are commonly reported after COVID-19 vaccination and heavy menstrual bleeding was added to the product information of vaccines Moderna Pfizer. The aim this review, using a systematic search, is provide an overview available literature on risk vaccination. Methods: review conducted according Preferred Reporting Items for Systematic reviews Meta-Analysis (PRISMA) guidelines. A PubMed search performed 15 August 2023, including solely quantitative studies in English Dutch. Results: total 61 were included, which 40 cross-sectional studies, 18 cohort three self-controlled case series. Outcomes included wide variety disorders, changes cycle length ( n = 54), amount 44), menses 30), experience (pre)menstrual pain 21), breakthrough 18). All found higher percentage at least one disorder first different types doses. Discussion: In conclusion, evidence suggests that may cause women reproductive age. However, there need more longitudinal because important limitations study designs many studies. Although short-lived predominantly mild, it healthcare professionals be informed about these potential adverse reactions assess events clinical trials vaccines.

Language: Английский

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Abnormal uterine bleeding diagnoses and care following COVID-19 vaccination

American Journal of Obstetrics and Gynecology, Journal Year: 2024, Volume and Issue: 230(5), P. 540.e1 - 540.e13

Published: Jan. 13, 2024

Language: Английский

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Menstrual disturbance associated with COVID-19 vaccines: A comprehensive systematic review and meta-analysis

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(5), P. e0320162 - e0320162

Published: May 16, 2025

The relationship between COVID-19 vaccines and menstrual disturbance is unclear, in part because researchers have measured different outcomes (e.g., delays vs. changes to cycle length) with various study designs. Menstrual disruption could be a decisive factor people's willingness accept the vaccine. We searched Medline, Embase, Web of Science for studies investigating length, flow volume, post-menopausal bleeding, unexpected or intermenstrual bleeding. Data were analyzed using fixed-effects meta-analysis Shore's adjusted confidence intervals heterogeneity. Seventeen >1·9 million participants analyzed. found 19% greater risk increase length as compared unvaccinated people pre-vaccination time-periods (summary relative (sRR): 1·19; 95% CI: 1·11-1·26; n = 23,718 participants). was same Pfizer-BioNTech (sRR: 1·15; 1·05-1·27; 16,595) Moderna 1·05-1·25; 7,523), similar AstraZeneca 1·27; 1·02-1·59; 532), higher Janssen 1·69; 1·14-2·52; 751) In first after vaccination, increased by

Language: Английский

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Prolongation of the Menstrual Cycle After Receipt of the Primary Series and Booster Doses of mRNA Coronavirus Disease 2019 (COVID-19) Vaccination

Obstetrics and Gynecology, Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 7, 2023

OBJECTIVE: To quantitatively evaluate the effect of a booster vaccination dose against coronavirus disease 2019 (COVID-19) on menstrual cycle in large-scale retrospective cohort study using tracking smartphone application (app). METHODS: Prospectively or retrospectively recorded data, including start and finish dates cycles, were collected with app. Detailed data vaccinations, side effects, participants' characteristics from questionnaire For each COVID-19 shot (first, second, third), within-individual changes length up to fourth postvaccination evaluated. RESULTS: Among 7,376 6,873 participants who had first second vaccine doses different respectively, cycles immediately after (first cycles) an average 0.22 days (95% CI, 0.06–0.39) 0.37 0.20–0.54) longer than prevaccination cycle. In contrast, among 1,672 received same cycle, was 4.21 3.69–4.72) longer. The returned level However, 4,768 third dose, 1.20 1.00–1.40) longer, prolongation 0.27 0.10–0.44) 0.41 0.22–0.59) persisting CONCLUSION: may have greater longer-lasting primary-series shots. Although size small, evidence effects immunization menstruation should be accumulated.

Language: Английский

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Adverse Menstrual Events Reported After and Before (or Without) COVID‐19 Vaccination: A Systematic Review and Meta‐Analysis of Comparative Observational Studies

Pharmacoepidemiology and Drug Safety, Journal Year: 2024, Volume and Issue: 33(8)

Published: Aug. 1, 2024

ABSTRACT Background Reports of adverse menstrual events emerged during the COVID‐19 vaccination campaign in multiple countries. This raised question whether these reports were caused by vaccines. The aim this systematic review was to evaluate comparative studies on topic (registered at PROSPERO [CRD42022324973]). Methods We included observational such as cohort and surveys comparing response self‐reported questionnaires between post‐ versus pre‐vaccination data. PubMed Cochrane Library searches conducted 1 September 2023. primary outcome incidence any prespecified event, measure risk ratio. meta‐analysis using Mantel–Haenszel method random effects model. summarized results factors well key findings included. Results retrieved 161 references from electronic databases additional sources lists. Of those, we considered 21 studies. event reported 12 resulted a pooled estimate (risk ratio 1.13; 95% CI, 0.96–1.31) that did not favor group. analysis constrained considerable clinical statistical heterogeneity. Risk for changes history infection, concern about vaccines, smoking, previous cycle irregularities, depression, stress, other issues. Conclusions group heterogeneity prevalent among Most suggested temporary, minor, nonserious.

Language: Английский

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Evaluation of menstrual irregularities following COVID-19 infection or vaccination: The impact of COVID anxiety and associated risk factors

Medicine, Journal Year: 2024, Volume and Issue: 103(26), P. e38771 - e38771

Published: June 28, 2024

There has been significant interest in the changes menstrual cycles following coronavirus disease 2019 (COVID-19) infection or vaccination. This study aimed to investigate evidence for such and their potential risk factors. We used a descriptive design gathered data by sharing an online survey questionnaire on social media platforms. The included questions regarding sociodemographic factors, cycle changes, COVID-19 anxiety. population comprised women aged 18 49 years from Izmir. All analyses were performed using Statistical Package Social Sciences 21.0. factors influencing irregularities determined after COVID binary logistic regression analysis, including univariate multivariate models. Among 465 participants, those with associate's degree had significantly higher of than high school diploma (P = .012). Anxiety scores emerged as factor .026). However, neither nor vaccination resulted characteristics > .05). Other variables, age, body mass index, smoking, not associated changes(P findings suggest that educational level anxiety may play role irregularities, whereas itself directly affect cycle.

Language: Английский

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Prevalence of menstrual alterations following COVID-19 vaccination: systematic review & meta-analysis

BMC Women s Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 19, 2024

Language: Английский

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An investigation into the effects of COVID-19 vaccines on Iranian women’s menstrual cycle

Italian Journal of Gynaecology and Obstetrics, Journal Year: 2023, Volume and Issue: 36(01), P. 82 - 82

Published: March 14, 2023

Objective.The COVID-19 virus disrupts the renin-angiotensin system by reducing expression of angiotensin-2 converting enzyme receptors in host cells, inducing an inflammatory response.This regulates ovarian follicular development and steroid hormone production.So, this study has been conducted to examine possible effects vaccines on menstrual cycle Iranian women. Materials Methods.In retrospective cohort study, online researcher-made questionnaire containing 32 multiple-choice questions was used over one month investigate changes after receiving among 916 eligible women aged 18 45 years.Results.The mean age participants 34.34 ± 8.37 years, 77.79% were married, 61.47% government employees.The highest number (n = 377, 39.68%) had vaccinated with Sinopharm.The most common disorder 189) Menorrhagia.Most disorders due AstraZeneca Sinopharm vaccines.The chance polymenorrhea Sputnik vaccine 1.88 times higher than (OR P 0.04, 95% CI 1.02, 3.46).The hypermenorrhea vaccination 2.77 0.01, 0.18, 0.74). Conclusions.Regardless type vaccine, females subjected may experience self-limiting abnormalities.Awareness before prevents further worries uninformed judgments that negatively impact public attitudes.

Language: Английский

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COVID-19 Vaccines and the Menstrual Cycle: A Cross-Sectional Study

Current Respiratory Medicine Reviews, Journal Year: 2023, Volume and Issue: 20(1), P. 24 - 30

Published: Dec. 1, 2023

Objective: This study aimed to explore the impact of various COVID-19 vaccines on menstrual cycle Jordanian women. Materials and Methods: We conducted a retrospective analysis tracked changes using an anonymous questionnaire written in local language. received 732 responses, after exclusions, 617 responses were analyzed. The covered six sectors: demographics, medical history, infection vaccination status, obstetric gynecological specific questions about length, flow, any symptoms before each vaccine shot. Participants included females who had type vaccine. Results: Among participants analyzed, two-thirds between ages 20-35, majority normal BMI (59.6%). Most single, nulliparous, never used contraception methods (79.3%, 82.0%, 93.8%, respectively). Only small percentage other risk factors influencing changes, such as surgical procedures (10.5%) medications (8.10%). Baseline information was recorded. Forty percent experienced duration, approximately one-fifth reported heavier more severe premenstrual syndrome (PMS) symptoms. Body mass index (BMI) directly correlated with bleeding intensity vaccination. Parity weakly proportional However, parity did not significantly correlate PMS symptoms, or cramps Conclusion: In population young, non-sexually active women BMI, most experience significant their cycles receiving shorter bleeding, frequent, painful, post-vaccination.

Language: Английский

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