Deep Eutectic Solvent as Green Solvent in Extraction of Biological Macromolecules: A Review

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(6), P. 3381 - 3381

Published: March 21, 2022

Greater awareness of environmental sustainability has driven many industries to transition from using synthetic organic solvents greener in their manufacturing. Deep eutectic (DESs) have emerged as a highly promising category green with well-demonstrated and wide-ranging applications, including use solvent extraction small-molecule bioactive compounds for food pharmaceutical applications. The DES an biological macromolecules, on the other hand, not been extensively studied. Thereby, feasibility employing biomacromolecule well elucidated. To bridge this gap, review provides overview emphasis its unique physicochemical properties that make it attractive (e.g., non-toxicity, biodegradability, ease preparation, renewable, tailorable properties). Recent advances three classes biomacromolecules-i.e., proteins, carbohydrates, lipids-were discussed future research needs were identified. importance DES's properties-particularly viscosity, polarity, molar ratio components, water addition-on extraction's performance discussed. Not unlike findings small molecules, biomacromolecules was concluded be generally superior solvents.

Language: Английский

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A Comprehensive Review on Deep Eutectic Solvents and Its Use to Extract Bioactive Compounds of Pharmaceutical Interest

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(1), P. 124 - 124

Published: Jan. 18, 2024

The extraction of bioactive compounds pharmaceutical interest from natural sources has been significantly explored in recent decades. However, the techniques used were not very efficient terms time and energy consumption; additionally, solvents for harmful environment. To improve environmental impact extractions at same increase yields, several new developed. Among most ones are ultrasound-assisted microwave-assisted extraction. These increased yield selectivity a smaller amount with decrease consumption. Nevertheless, high volume organic was still extraction, causing subsequent problem. Neoteric appeared as green alternatives to solvents. neoteric solvents, deep eutectic evidenced be one best due their intrinsic characteristics. considered because they made up such sugars, amino acids, carboxylic acids having low toxicity degradability. In addition, simple prepare, an atomic economy 100%, attractive physicochemical properties. Furthermore, huge number that can synthesize these make them useful since tailored selective towards specific component or class components. main aim this paper is give comprehensive review which describes properties, characteristics, production methods well its application extract interest. Additionally, overview more sustainable also given.

Language: Английский

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Toxicity test profile for deep eutectic solvents: A detailed review and future prospects

Chemosphere, Journal Year: 2024, Volume and Issue: 350, P. 141097 - 141097

Published: Jan. 1, 2024

Language: Английский

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Biocatalysis for the Synthesis of Active Pharmaceutical Ingredients in Deep Eutectic Solvents: State-of-the-Art and Prospects

Catalysts, Journal Year: 2024, Volume and Issue: 14(1), P. 84 - 84

Published: Jan. 19, 2024

Biocatalysis holds immense potential for pharmaceutical development as it enables synthetic routes to various chiral building blocks with unparalleled selectivity. Therein, solvent and water use account a large contribution the environmental impact of reactions. In spirit Green Chemistry, transition from traditional highly diluted aqueous systems intensified non-aqueous media overcome limitations (e.g., shortages, recalcitrant wastewater treatments, low substrate loadings) has been observed. Benefiting spectacular advances in enzyme stabilization techniques, plethora biotransformations non-conventional have established. Deep eutectic solvents (DESs) emerge sort (potentially) greener medium increasing biocatalysis. This review discusses state-of-the-art DESs focus on biocatalytic pathways synthesis active ingredients (APIs). Representative examples different classes are discussed, together critical vision discussing prospects using

Language: Английский

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Cobalt Recovery from Li-Ion Battery Recycling: A Critical Review

Metals, Journal Year: 2021, Volume and Issue: 11(12), P. 1999 - 1999

Published: Dec. 10, 2021

The increasing demand for Li-ion batteries electric vehicles sheds light upon the Co supply chain. metal is crucial to cathode of these batteries, and leading global producer D.R. Congo (70%). For this reason, it considered critical/strategic due risk interruption in short medium term. Due consumption transportation market, might be a secondary source Co. outstanding amount spent makes them core urban mining warranting special attention. Greener technologies recovery are necessary achieve sustainable development. As result sourcing challenges, study devoted reviewing techniques recovery, such as acid leaching (inorganic organic), separation (solvent extraction, ion exchange resins, precipitation), emerging technologies—ionic liquids, deep eutectic solvent, supercritical fluids, nanotechnology, biohydrometallurgy. A dearth research from discussed throughout manuscript within broader overview. strictly connected Sustainability Development Goals (SDG) number 7, 8, 9, 12.

Language: Английский

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A review on recent applications of deep eutectic solvents in microextraction techniques for the analysis of biological matrices

Advances in Sample Preparation, Journal Year: 2022, Volume and Issue: 1, P. 100007 - 100007

Published: Feb. 1, 2022

In general, the analysis of biological matrices is challenging and a sample preparation step employing extraction/cleanup techniques required. Liquid-phase microextraction using deep eutectic solvents has been exploited in numerous applications because these exhibit fascinating physico-chemical properties addition to simple straightforward preparation. Varied configurations strategies have examined for determination different classes analytes, methodologies offer environmentally friendly workflows with low solvent consumption, rapid experimental procedures, satisfactory analytical performance. this review, developments related use approaches are briefly discussed focus on studies reported from 2017 2021.

Language: Английский

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Combined effect of hot water and deep eutectic solvent (DES) pretreatment on a lignocellulosic biomass mixture for improved saccharification efficiency

Bioresource Technology Reports, Journal Year: 2022, Volume and Issue: 17, P. 100986 - 100986

Published: Feb. 1, 2022

Language: Английский

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Are natural deep eutectic solvents always a sustainable option? A bioassay-based study

Environmental Science and Pollution Research, Journal Year: 2022, Volume and Issue: 30(7), P. 17268 - 17279

Published: Oct. 4, 2022

The traditional use of organic solvents in various branches industry is being rethought as these compounds very often display high volatility, toxicity and lipophilicity (related to the ability interact with biological membranes). More recently, developments field Green Chemistry are focusing on design more sustainable cost-effective solvent alternatives like Ionic Liquids (ILs), bio-based natural deep eutectic (NADESs). present study aimed at performing an ecotoxicological screening 15 NADESs using extensive set marine freshwater bioassays, based different endpoints following: immobilization crustacean Daphnia magna, growth inhibition Raphidocelis subcapitata Phaeodactylum tricornutum, larval development alterations serpulid Ficopomatus enigmaticus bioluminescence Aliivibrio fischeri. What emerged was a general absence all samples. However, both algal assays showed certain degree biostimulation, up over 100% increase respect controls 8 out tested subcapitata. Despite NADESs-induced negligible effects invertebrates, encouraging their labelling "sustainable" solvents, liability intentional or accidental release into aquatic systems may represent serious risk terms ecosystem functioning impairments.

Language: Английский

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Challenges and Possibilities of Deep Eutectic Solvent-Based Membranes

Industrial & Engineering Chemistry Research, Journal Year: 2022, Volume and Issue: 61(48), P. 17397 - 17422

Published: Nov. 22, 2022

Deep eutectic solvents (DES) are a category of new class that can overcome some the main drawbacks typical and ionic liquids (ILs). DES have been widely investigated applied by research community in several applications since their invention. Over past years, use has directed to production materials items for products processes. This is case implementation various fields chemical engineering separations. very recently initiated be combined into membranes membrane In this regard, Review timely elucidates current progress utilizing generation preparation. work, different techniques, methods, strategies incorporating polymer concepts according final application reviewed. Particular emphasis devoted most relevant development works results. After literature was analyzed, challenges possibilities were declared.

Language: Английский

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Molecular imprinting with deep eutectic solvents: Synthesis, applications, their significance, and benefits

Journal of Molecular Liquids, Journal Year: 2022, Volume and Issue: 362, P. 119696 - 119696

Published: June 24, 2022

Language: Английский

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