Exploring the Potential of PEG-Based Deep Eutectic Solvents as a Sustainable Alternative for Extraction of Biological Macromolecules Bovine Serum Hemoglobin DOI Creative Commons
M. S. Siddiqui, Md. Sayem Alam, Maroof Ali

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: 10(7), P. 6839 - 6856

Published: Feb. 14, 2025

In recent years, deep eutectic solvents (DESs) have garnered significant attention as promising green alternatives to conventional organic for a wide range of applications. this study, four novel polyethylene glycol (PEG)-based DESs were prepared and evaluated their physicochemical properties, including density, dynamic viscosity, kinematic viscosity. Fourier transform infrared spectroscopy (FT-IR) NMR analyses revealed substantial intermolecular interactions between the hydrogen bond donor acceptor components, confirming formation stable DES systems. The application was tested in biological separation, specifically selective extraction bovine serum hemoglobin (BHb). This study demonstrates efficacy PEG-based selectively extracting BHb. Among studied, DES-4 (PEG-600) achieved highest efficiency 88%, while maintaining protein stability. Spectroscopic techniques, UV–visible, fluorescence, light scattering, circular dichroism, FT-IR, employed investigate mechanism, conformational changes structure, DES-protein interactions. These methods provided insights into structural stability functionality BHb during process. characterizations confirmed unique properties DESs, making them viable candidates sustainable extraction. Their compatibility, excellent efficiency, short separation times underscore potential environmentally friendly long-lasting substitutes techniques. highlights advancement chemistry biotechnological applications, offering an efficient platform integrity.

Language: Английский

Liquid-liquid microextraction techniques based on in-situ formation/decomposition of deep eutectic solvents DOI

Raheleh Ahmadi,

Ebaa Adnan Azooz, Yadollah Yamini

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 161, P. 117019 - 117019

Published: March 11, 2023

Language: Английский

Citations

58
Research progress in the use of liquid-liquid extraction for food flavour analysis DOI

Haijuan Jiang,

Shaoxiang Yang,

Hongyu Tian

et al.

Trends in Food Science & Technology, Journal Year: 2023, Volume and Issue: 132, P. 138 - 149

Published: Jan. 18, 2023

Language: Английский

Citations

56
Applications of (natural) deep eutectic solvents in liquid phase microextraction: A review DOI Creative Commons
Fotouh R. Mansour, Alaa Bedair, Mahmoud Hamed

et al.

Microchemical Journal, Journal Year: 2024, Volume and Issue: 198, P. 110178 - 110178

Published: Feb. 17, 2024

Natural deep eutectic solvents (NADES) have gained significant attention as green due to their unique properties, such high solubility, low volatility, toxicity, and tunability. Liquid phase microextraction (LPME) is a sample preparation technique that plays crucial role in analytical chemistry, the use of NADES extraction LPME offers numerous benefits compared traditional solvents. can effectively extract bioactive compounds from natural sources without damaging structure activity. They also serve catalysts organic reactions, enhancing bioavailability compounds. In addition, be utilized mobile or stationary phases chromatographic techniques for separating analyzing The review highlights efficiency terms ability, analyte stabilization capacity, detection compatibility. Moreover, availability components, ease preparation, cost-effectiveness, biodegradability make attractive researchers field chemistry. applications contribute principles chemistry by providing sustainable environmentally friendly approach preparation. A comprehensive overview liquid provided, emphasizing potential advancing practices

Language: Английский

Citations

43
Rapid synergistic cloud point extraction based on hydrophobic deep eutectic solvent combined with hydride generation atomic absorption spectrometry for determination of selenium in tea samples DOI
Rana Kadhim Ridha,

Doaa H. Alasady,

Ebaa Adnan Azooz

et al.

Journal of Food Composition and Analysis, Journal Year: 2024, Volume and Issue: 132, P. 106286 - 106286

Published: May 6, 2024

Language: Английский

Citations

21
Deep eutectic solvents in analysis, delivery and chemistry of pharmaceuticals DOI
Saurabh B. Ganorkar,

Pranay M. Hadole,

Mangesh R. Patil

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125278 - 125278

Published: Jan. 1, 2025

Language: Английский

Citations

2
Green microextraction methodologies for sample preparations DOI

John M. Kokosa,

Andrzej Przyjazny

Green Analytical Chemistry, Journal Year: 2022, Volume and Issue: 3, P. 100023 - 100023

Published: July 26, 2022

Language: Английский

Citations

55
Current understanding and insights towards protein stabilization and activation in deep eutectic solvents as sustainable solvent media DOI
Niketa Yadav,

Pannuru Venkatesu

Physical Chemistry Chemical Physics, Journal Year: 2022, Volume and Issue: 24(22), P. 13474 - 13509

Published: Jan. 1, 2022

Deep eutectic solvents (DESs) have emerged as a new class of green, designer and biocompatible solvents, an alternative to conventional organic ionic liquids (ILs) which are comparatively toxic non-biodegradable.

Language: Английский

Citations

53
A Critical Review of Emerging Hydrophobic Deep Eutectic Solvents’ Applications in Food Chemistry: Trends and Opportunities DOI
Isaac Duah Boateng

Journal of Agricultural and Food Chemistry, Journal Year: 2022, Volume and Issue: 70(38), P. 11860 - 11879

Published: Sept. 13, 2022

Due to their low cost, biodegradability, and ease of preparation, deep eutectic solvents (DESs) are considered promising green alternatives conventional solvents, as exploiting has been a research focus for achieving sustainable development goals. Most DESs in published studies hydrophilic. On the other hand, DES's hydrophilicity restricts its practical applicability just polar molecules, which is vital disadvantage this extractant. Hydrophobic DES (HDES) developed new extractant adept at extracting nonpolar inorganic organic compounds from aqueous systems. Although there little on HDESs (HDES publications account <10% DES), specific intriguing applications have discovered, requiring investigation comparisons. As result, review covers emerging HDES detecting pesticide residues, food additives, contaminants packaging, heavy metals, separation extraction processes food. According available literature, potential overcome limitations hydrophilic be used broader range with greater efficiency, received attention. expected substitute lot harmful extractants analytical reasons (food chemistry) future. Besides, were reviewed, future provided. This will serve reference chemistry advocates practitioners science who want minimize pollution improve efficiency benefit further HDESs.

Language: Английский

Citations

39
Design Strategy and Application of Deep Eutectic Solvents for Green Synthesis of Nanomaterials DOI Creative Commons
Nguyễn Nhật Nam, Hoang Dang Khoa, Kieu The Loan Trinh

et al.

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(7), P. 1164 - 1164

Published: March 24, 2023

The first report of deep eutectic solvents (DESs) was released in 2003 and identified as a new member ionic liquid (IL), involving innovative chemical physical characteristics. Using green solvent technology concerning economical, practical, environmental aspects, DESs open the window for sustainable development nanomaterial fabrication. assist different fabrication processes design nanostructures with specific morphology properties by tunable reaction conditions. synthesis reactions can reduce required high temperature pressure conditions decreasing energy consumption risk contamination. This review paper provides recent applications advances strategy nanomaterials. application wet-chemical processes, nanosize reticular material fabrication, electrodeposition/electrochemical nanostructures, electroless deposition, based nano-catalytic nanofluidic systems are discussed highlighted this review.

Language: Английский

Citations

38
Extraction of Bioactive Compounds from C. vulgaris Biomass Using Deep Eutectic Solvents DOI Creative Commons
Maria Myrto Dardavila, Sofia Pappou, Maria G. Savvidou

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(1), P. 415 - 415

Published: Jan. 3, 2023

C. vulgaris microalgae biomass was employed for the extraction of valuable bioactive compounds with deep eutectic-based solvents (DESs). Particularly, Choline Chloride (ChCl) based DESs, ChCl:1,2 butanediol (1:4), ChCl:ethylene glycol (1:2), and ChCl:glycerol (1:2) mixed water at 70/30 w/w ratio were used that purpose. The extracts’ total carotenoid (TCC) phenolic contents (TPC), as well their antioxidant activity (IC50), determined within process identification most efficient solvent. This screening procedure revealed (1:4)/H2O compelling solvent; thus, it thereafter optimization. Three parameters, i.e., solvent-to-biomass ratio, temperature, time studied regarding impact on extract’s TCC, TPC, IC50. For experimental design optimization, statistical tool Response Surface Methodology used. resulting models’ predictive capacity confirmed experimentally by carrying out two additional extractions under conditions different from design.

Language: Английский

Citations

35