Journal of the Indian Chemical Society, Journal Year: 2022, Volume and Issue: 100(1), P. 100862 - 100862
Published: Dec. 27, 2022
Language: Английский
Molecules, Journal Year: 2023, Volume and Issue: 28(2), P. 618 - 618
Published: Jan. 7, 2023
Spirooxindoles occupy an important place in heterocyclic chemistry. Many natural spirooxindole-containing compounds have been identified as bio-promising agents. Synthetic analogs also synthesized utilizing different pathways. The present article summarizes the recent development of both and synthetic prepared from isatin or its derivatives reported last five years. spirooxindoles are categorized based on their mentioned biological properties.
Language: Английский
Citations
66
RSC Advances, Journal Year: 2024, Volume and Issue: 14(9), P. 5690 - 5728
Published: Jan. 1, 2024
VEGF, an important category of tyrosine kinases, and its receptors (VEGFR) are hyper-activated in different cancers. The recently reported indolyl analogs with potential antineoplastic VEGFR inhibitory properties highlighted.
Language: Английский
Citations
8
Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 143, P. 107091 - 107091
Published: Jan. 4, 2024
Language: Английский
Citations
6
Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 274 - 274
Published: Feb. 19, 2025
The p53, often referred to as the "guardian of genome", is a well-established tumor-suppressor protein that plays critical role in regulating cell cycle, DNA repair, differentiation, and apoptosis, with its activity primarily modulated by MDM2 (murine double minute 2, also known HDM2 humans). Disrupting protein-protein interaction between p53 represents promising therapeutic strategy for developing anticancer agents. Recent studies have shown several spirooxindole-containing compounds exhibit significant antitumor properties, inhibiting p53-MDM2 interaction. This review provides an overview structure-based spirooxindoles could potential. It highlights findings from past decade concerning their antiproliferative properties implications interfering discussion includes various analogs candidates optimizing leads drug discovery programs aimed at novel clinically effective
Language: Английский
Citations
0
Journal of Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 1011, P. 123127 - 123127
Published: April 3, 2024
Language: Английский
Citations
2
Current Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 31(27), P. 4286 - 4311
Published: Jan. 21, 2024
Abstract: The Knoevenagel condensation is a powerful and primary step for the development of carbon-carbon bond transformations. These condensations offer versatile products/ intermediates diverse uses in polymers, cosmetics, chemical industries, medicinal chemistry. Various homogenous heterogenous catalysts have been found to promote reaction, both environmentally economically. Due their attractive use production pharmaceutical drugs, they are proven be main force that drives synthesis involving numerous multi-component multistep reactions. present study, therefore, aims summarise reported reactions using metal-free resulting pharmaceutically useful compounds with anti-cancer, anti-tumor, anti-oxidant, anti-malarial, anti-diabetic, anti- bacterial activities. By considering factors like structure-activity relationships (SARs), reaction conditions, steps involved, as well advantages limitations particular approach, we also provide general framework direction order achieve superior characteristics catalyst.
Language: Английский
Citations
1
Drug Research, Journal Year: 2023, Volume and Issue: 73(03), P. 164 - 169
Published: Jan. 9, 2023
Abstract Malaria is one of the world’s most devastating diseases, infecting well over 300 million people annually and killing between 2 3 worldwide. Increasing parasite resistance to many existing drugs exacerbating disease. Resistance commonly used malarial increasing need develop new urgently. Due slow pace substantial costs drug development, repurposing old which recently increasingly becoming an attractive proposition highly efficient effective way discovery led us study rifampicin for this purpose. The present paper aims investigate route Plasmodium falciparum apicoplast-targeted proteins that putatively encode β subunits RNA polymerase with objective antimalarial drug. Homology searching conserved binding site functional analysis rpoB gene were done. Multiple Sequence alignment was compared in E.coli – M. tuberculosis rpoB. Docking studies Rifampicin complex also done finding affinity. results computational showed a potential malaria.
Language: Английский
Citations
3
Journal of the Indian Chemical Society, Journal Year: 2022, Volume and Issue: 99(11), P. 100759 - 100759
Published: Oct. 8, 2022
Language: Английский
Citations
4
From Chemistry Towards Technology Step-By-Step, Journal Year: 2024, Volume and Issue: 5(4), P. 58 - 65
Published: Dec. 23, 2024
тетрагидрохромено[2,3d]пиримидин-2-оны, иодистый метил, ангидрид уксусной кислоты, алкилирование, ацилирование Аннотация.В данной работе представлены результаты синтеза и характеристики семи новых производных тетрагидрохромено[2,3-d]пиримидин-2-онов, полученных путем селективной модификации гидроксильной группы в положении С-8.Реакции алкилирования ацетилирования были успешно использованы для введения заместителей молекулу, что позволило получить серию гетероциклических соединений с выходами до 94 %.Характеристика проведена методами ЯМР-спектроскопии (¹H ¹³C), а также масс-спектрометрии.
Language: Русский
Citations
0
From Chemistry Towards Technology Step-By-Step, Journal Year: 2024, Volume and Issue: 5(4), P. 134 - 141
Published: Dec. 23, 2024
The paper presents the results of synthesis and characterisation seven new tetrahydrochromeno[2,3-d]pyrimidin-2-ones derivatives obtained by selective modification hydroxyl group at C-8 position. authors successfully used alkylation acetylation reactions to introduce substituents into molecule. This resulted in a series heterocyclic compounds with yields up 94 %. characterised NMR spectroscopy (¹H ¹³C) mass spectrometry.
Language: Английский
Citations
0