A comprehensive review of Sjögren's syndrome: classification criteria, risk factors, and signaling pathways DOI Creative Commons

Ting Zhao,

Runrun Zhang, Zhaofu Li

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(17), P. e36220 - e36220

Published: Aug. 15, 2024

Sjögren's syndrome (SS) is a chronic autoimmune disease that affects the exocrine glands and may lead to range of systemic symptoms impact various organs. Both innate adaptive immune pathways might trigger disease. Studying signaling underlying SS crucial for enhancing diagnostic therapeutic effectiveness. poses an ongoing challenge medical professionals owing limited options available. This review offers comprehensive understanding intricate nature SS, encompassing classification criteria, risk factors, in immunity inflammation. The advancements summarized herein have potential spark new avenues research into SS.

Language: Английский

Weighted Gene Co-expression Network Analysis and Machine Learning Validation for Identifying Major Genes Related to Sjogren’s Syndrome DOI
Qiang Luo, Kaiwen Wu, He Li

et al.

Biochemical Genetics, Journal Year: 2024, Volume and Issue: unknown

Published: April 28, 2024

Language: Английский

Citations

1
Multi-omics analysis uncovered systemic lupus erythematosus and COVID-19 crosstalk DOI Creative Commons

Zekai Nian,

Yicheng Mao,

Zexia Xu

et al.

Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(1)

Published: June 11, 2024

Abstract Background Studies have highlighted a possible crosstalk between the pathogeneses of COVID-19 and systemic lupus erythematosus (SLE); however, interactive mechanisms remain unclear. We aimed to elucidate impact on SLE using clinical information underlying both diseases. Methods RNA-seq datasets were used identify shared hub gene signatures SLE, while genome-wide association study delineate interaction key signaling pathways. Finally, single-cell determine primary target cells expressing genes Results may affect patients with through hematologic involvement exacerbated inflammatory responses. identified 14 that significantly associated interferon (IFN)-I/II. also screened obtained four core transcription factors related these genes, confirming regulatory role IFN-I/II-mediated Janus kinase/signal transducers activators (JAK-STAT) pathway genes. Further, can interact via IFN-I/II receptors, promoting levels monokines, including interleukin (IL)-6/10, tumor necrosis factor-α, IFN-γ, elevating incidence rate risk cytokine release syndrome. Therefore, in COVID-19, TFs are enriched within monocytes/macrophages. Conclusions The promotes activation IFN-I/II-triggered JAK-STAT These findings provide new direction rationale for diagnosing treating SLE–COVID-19 comorbidity.

Language: Английский

Citations

1
Toll-like Receptor Homologue CD180 Ligation of B Cells Upregulates Type I IFN Signature in Diffuse Cutaneous Systemic Sclerosis DOI Open Access
Szabina Erdő-Bonyár,

Judit Rapp,

Rovéna Subicz

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7933 - 7933

Published: July 20, 2024

Type I interferon (IFN-I) signaling has been shown to be upregulated in systemic sclerosis (SSc). Dysregulated B-cell functions, including antigen presentation, as well antibody and cytokine production, all of which may affected by IFN-I signaling, play an important role the pathogenesis disease. We investigated signature 71 patients with more severe form disease, diffuse cutaneous SSc (dcSSc), 33 healthy controls (HCs). Activation via Toll-like receptors (TLRs) can influence cascade; thus, we analyzed effects TLR homologue CD180 ligation on B cells. stimulation augmented phosphorylation signal transducer activator transcription 1 (STAT1) dcSSc cells (

Language: Английский

Citations

1
Type I Interferons in Systemic Autoimmune Rheumatic Diseases: Pathogenesis, Clinical Features and Treatment Options DOI Open Access
Konstantinos Drougkas, Charalampos Skarlis, Clio P. Mavragani

et al.

Mediterranean Journal of Rheumatology, Journal Year: 2024, Volume and Issue: 35(Suppl 2), P. 365 - 365

Published: June 1, 2024

Type I interferon (IFN) pathway dysregulation plays a crucial role in the pathogenesis of several systemic autoimmune rheumatic diseases (SARDs), including lupus erythematosus (SLE), Sjögren's disease (SjD), sclerosis (SSc), dermatomyositis (DM) and rheumatoid arthritis (RA). Genetic epigenetic alterations have been involved dysregulated type IFN responses disorders. Aberrant production secretion associated with distinct clinical phenotypes, activity, severity as well differentiated treatment among SARDs. In this review, we provide an overview IFNs SLE, RA, SjD, SSc, DM focusing on pathophysiological, clinical, therapeutical aspects.

Language: Английский

Citations

1
A comprehensive review of Sjögren's syndrome: classification criteria, risk factors, and signaling pathways DOI Creative Commons

Ting Zhao,

Runrun Zhang, Zhaofu Li

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(17), P. e36220 - e36220

Published: Aug. 15, 2024

Sjögren's syndrome (SS) is a chronic autoimmune disease that affects the exocrine glands and may lead to range of systemic symptoms impact various organs. Both innate adaptive immune pathways might trigger disease. Studying signaling underlying SS crucial for enhancing diagnostic therapeutic effectiveness. poses an ongoing challenge medical professionals owing limited options available. This review offers comprehensive understanding intricate nature SS, encompassing classification criteria, risk factors, in immunity inflammation. The advancements summarized herein have potential spark new avenues research into SS.

Language: Английский

Citations

1