Effects of Huang-Lian-Jie-Du decoction on improving skin barrier function and modulating T helper cell differentiation in 1-chloro-2,4-dinitrobenzene-induced atopic dermatitis mice DOI Creative Commons

H. Zhang,

Q. Li,

Yaxing Li

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 20, 2024

Background: Atopic dermatitis (AD) is among the most frequently encountered skin diseases, bothering a considerable number of patients. Today, corticosteroids and antihistamines are numerous drugs applied for therapy AD. However, lengthy use them contributes to side effects, such as physiological changes in skin. As an alternative supplementary therapy, traditional Chinese medicine has become trend AD treatment. Huang-Lian-Jie-Du decoction (HLJDD), renowned herbal formula been employed treat inflammatory diseases its role regulating immunity remains unclear. The object this study was elucidate efficacy HLJDD reveal implicit mechanism from immunological perspective AD-like mice. Methods: In brief, 1-chloro-2,4-dinitrobenzene (DNCB) sensitization phase (1% DNCB) stimulation (1.5% were BALB/c dexamethasone (DXMS) administered orally Mice spleens collected evaluate HLJDD. 16S rRNA sequencing commensal microbiota fecal. vitro , spleen CD4 + T cells bone marrow-derived mast (BMMCs) co-cultured explore modulation helper (Th) phenotyping. Results: showcased substantial amelioration through upregulation FLG, LOR, AQP3, reducing scratching behaviors mice, Also, quantity infiltrated (MCs), pruritus-related mRNA decreased. addition, expression OX40/OX40L decreased by HLJDD, which critical Th-cell With treatment Th1/Th2 Th17/Treg ratios mice became balanced. structure affected could also improve imbalance . Conclusion: symptoms alleviating via Th2 expression. enhanced relative diversity changed intestinal microbiota. An in-depth found that balance ratio Th1/Th2, signaling pathway.

Language: Английский

Skin Barrier in Normal and Allergic Horses: What Do We Know? DOI Creative Commons
Rosanna Marsella

Veterinary Sciences, Journal Year: 2025, Volume and Issue: 12(2), P. 91 - 91

Published: Jan. 24, 2025

Information on skin barrier in horses is limited. A study the epidermal ultrastructure of normal and allergic documented disorganized amorphous intercellular lipids stratum corneum samples. These findings are similar to atopic canine human skin. Currently, there no published comparing function parameters between horses; thus, functional implications ultrastructural changes unknown. In horses, body location, gender, breed, ambient conditions affect parameters, such as Transepidermal Water Loss. Skin microbiome studies have highlighted importance season environmental conditions, since housed together share microbiomes. dysbiosis predominance staphylococcus been described with pastern dermatitis. Transcriptomic epidermis found that lesional has substantial transcriptomic differences when compared healthy skin, namely downregulation genes tight junctions, keratins, upregulation serine proteases IL-13. Keratinocytes harvested from insect bite hypersensitivity show IL-31 gene expression under stimulation. While more research clearly needed, preliminary results seem support horses.

Language: Английский

Citations

0
Prediction of Skin Irritation by Noninvasive Bioengineering Methods DOI
Razvigor Darlenski, Joachim W. Fluhr

Published: Jan. 1, 2025

Language: Английский

Citations

0
The Origin, Intricate Nature, and Role of the Skin Surface pH (pHSS) in Barrier Integrity, Eczema, and Psoriasis DOI Creative Commons
Dalibor Mijaljica,

Joshua P. Townley,

Daniel J. Klionsky

et al.

Cosmetics, Journal Year: 2025, Volume and Issue: 12(1), P. 24 - 24

Published: Feb. 3, 2025

The inherent acidic nature of the stratum corneum (SC), so-called “acid mantle”, has a multitude effects on skin barrier integrity owing to its (patho)physiological role in homeostasis, antimicrobial defense, and inflammation. Several salient SC acidifying mechanisms, including breakdown FLG (filaggrin) protein, lipid processing, activity sodium proton pump SLC9A1/NHE1, are indispensable for structural functional cohesion as they contribute immensely origin, generation, maintenance, overall acidification surface pH (pHss). As many endogenous exogenous factors can affect pHss, pHss inevitably deviate from optimum. elevation is often accompanied by abnormalities metabolism organization, cohesion, commonly observed eczema, which associated with symptoms dry skin, inflammation, pruritus, infection. In psoriasis, it seems that altered well; however, this case, likely be lower than physiological pHss. Due negative an both eczema been suggested maintain at levels utilizing pH-balanced topical cleansers moisturizers improve skin’s benefiting moisturization regeneration organization barrier. principal aim review gather understanding existing research stimulate critical thinking inspire innovative ideas about ‘known unknowns’, considering intricate nature, prime human health, well pathogenesis psoriasis.

Language: Английский

Citations

0
Topical administration of coumarin derivatives alleviates skin inflammatory symptoms in atopic dermatitis model DOI
Goeun Han,

Bon‐Hee Gu,

Sun Young Park

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 186, P. 118004 - 118004

Published: March 31, 2025

Language: Английский

Citations

0
The role of LINC00114 in atopic dermatitis: modulating inflammation and epidermal barrier dysfunction DOI

Yifeng Sun,

Xin Li,

Ning-Ning Deng

et al.

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: April 1, 2025

Language: Английский

Citations

0
A tri-compound formula comprising ginsenoside Rg1, tetrandrine and icariin alleviates atopic dermatitis symptoms in a mouse model DOI
Ying Wu,

Xiaoqi Wang,

Jia‐Ying Wu

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156737 - 156737

Published: April 1, 2025

Language: Английский

Citations

0
Autophagy-Mediated Cellular Remodeling during Terminal Differentiation of Keratinocytes in the Epidermis and Skin Appendages DOI Creative Commons
Leopold Eckhart, Флориан Грубер, Supawadee Sukseree

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(20), P. 1675 - 1675

Published: Oct. 10, 2024

The epidermis of the skin and appendages, such as nails, hair sebaceous glands, depend on a balance cell proliferation terminal differentiation in order to fulfill their functions at interface body environment. epithelial cells skin, commonly referred keratinocytes, involves major remodeling processes that generate metabolically inactive remnants serving building blocks epidermal stratum corneum, nail plates shafts. Only gland results disintegration holocrine secretion. A series studies performed past decade have revealed lysosome-dependent intracellular degradation mechanism autophagy is active during keratinocyte differentiation, blockade significantly alters properties products. Here, we present model for autophagy-mediated organelles cytosolic proteins an important contributor cellular differentiation. roles are discussed comparison alternative mechanisms context programmed death integral end point

Language: Английский

Citations

3
From stimuli-responsive polymers to nanosystems and electrocircuits: an update on the current state of polymeric hydrogel microneedles for wound healing DOI Creative Commons
Patrícia C. Pires,

Andreia Renca,

Inês Amaro

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 102, P. 106395 - 106395

Published: Nov. 8, 2024

Language: Английский

Citations

2
Atopic dermatitis: pathogenesis and therapeutic intervention DOI Creative Commons
Chengcheng Yue, Hong Zhou,

Xiaoyan Wang

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(12)

Published: Dec. 1, 2024

Abstract The skin serves as the first protective barrier for nonspecific immunity and encompasses a vast network of skin‐associated immune cells. Atopic dermatitis (AD) is prevalent inflammatory disease that affects individuals all ages races, with complex pathogenesis intricately linked to genetic, environmental factors, dysfunction well dysfunction. Individuals diagnosed AD frequently exhibit genetic predispositions, characterized by mutations impact structural integrity barrier. This leads release alarmins, activating type 2 pathway recruiting various cells skin, where they coordinate cutaneous responses. In this review, we summarize experimental models provide an overview its therapeutic interventions. We focus on elucidating intricate interplay between system regulatory mechanisms, commonly used treatments AD, aiming systematically understand cellular molecular crosstalk in AD‐affected skin. Our overarching objective novel insights inform potential clinical interventions reduce incidence AD.

Language: Английский

Citations

2
Halting the Vicious Cycle of Atopic Dermatitis: Empowered by Scientific Understanding DOI Creative Commons
Sara Brown, Jóhann E. Guðjónsson

Journal of Investigative Dermatology, Journal Year: 2024, Volume and Issue: 144(5), P. 917 - 918

Published: April 19, 2024

The progress in our understanding of atopic dermatitis (AD) (atopic eczema) the last 10 years has been remarkable. Nearly half scientific papers ever published on AD have written years. This contribution knowledge, parallel with technological and pharmaceutical progress, transformed ability to treat some most severe forms AD. Notably, we seen advent biologics such as anti–IL-4 receptor biologic dupilumab (Simpson et al, 2016), 2 anti–IL-13 agents (tralokinumab [Wollenberg 2021] lebrikizumab [Silverberg 2023]), small-molecular Jak inhibitors (the Jak1 upadacitinib [Guttman-Yassky abrocitinib [Simpson 2020] Jak1/Jak2 inhibitor baricitinib [Zhou 2021]).

Language: Английский

Citations

0