ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: Dec. 30, 2024
Abstract
The
demand
for
smaller
nanomaterials
with
biocompatible
properties
has
become
increasingly
imperative
in
the
quest
to
combat
microbial
infections
and
cancer.
This
requires
modifying
chemical
process.
In
this
investigation,
polyvinylpyrrolidone–silver
chloride
(PVP–AgCl)
(NMs)
were
developed
via
a
sonochemical
method
involving
Ag
+
sourced
from
AgNO
3
metal
precursor
Cl
−
NaCl,
assistance
of
capping
agent
PVP.
Synthesized
NMs
characterized
using
XRD,
FTIR,
SEM/EDS,
DLS
TEM.
SEM
analysis
indicated
spindle‐like
structures
star‐shaped
formations
at
edges,
whereas
TEM
showed
size
∼24
±
nm.
Furthermore,
PVP–AgCl
exhibited
zeta
potential
approximately
−18.34
mV,
an
average
hydrodynamic
diameter
127.7
1.287
nm
polydispersity
index
0.1879.
anticancer
activity
tested
against
cervical
cancer
cells
(HeLa).
addition,
toxicity
studies
fibroblast
cell
(L929)
revealed
that
demonstrate
significant
while
showing
minimal
toward
L929
cells.
antimicrobial
was
S.
aureus
E.
coli
strains.
prepared
exhibit
properties.
These
findings
suggest
are
used
biomedicine
coatings
applications.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Feb. 14, 2024
Abstract
Nanoengineered
chitosan
functionalized
titanium
dioxide
biohybrids
(CTiO
2
@NPs)
were
prepared
with
Amomum
subulatum
Roxb
extract
via
one-pot
green
method
and
assessed
by
UV–Vis
spectroscopy,
XRD,
SEM
EDAX
analyses.
As
revealed
XRD
pattern,
the
nanohybrids
exhibits
a
rutile
TiO
crystallites
around
45
nm
in
size.
The
emergence
of
Ti–O–Ti
bond
is
identified
observing
peak
between
400
800
cm
−1
.
A
wide
bandgap
(4.8
eV)
has
been
observed
CTiO
@NPs,
due
to
quantum
confinement
effects
oxygen
vacancies
reveal
intriguing
potential
developed
for
various
applications.
Surface
flaws
an
emission
band
at
382,
437,
482,
517,
556
nm.
They
also
exhibit
better
antibacterial
performances
using
well
diffusion
against
Staphylococcus
aureus
,
Bacillus
substilis
Klebsiella
pneumonia
Escherichia
coli
@NPs
discovered
have
free
radical
scavenging
activity
on
DPPH
analysis
IC
50
value
as
95.80
μg/mL
standard
(Vitamin
C)
87.62
μg/mL.
exhibited
anticancer
properties
osteosarcoma
(MG-63)
cell
line.
All
these
findings
suggest
that
there
forum
further
useful
therapeutic
Therefore,
we
claim
nano-engineered
carbohydrated
phytohybrid
promising
solution
bacterial
infections
bone
cancer.
Biomaterials Research,
Journal Year:
2025,
Volume and Issue:
29
Published: Jan. 1, 2025
Effective
drug
delivery
relies
on
the
selection
of
suitable
carriers,
which
is
crucial
for
protein-based
therapeutics
such
as
tumor
necrosis
factor-related
apoptosis-inducing
ligand
(TRAIL).
One
key
advantages
TRAIL
its
ability
to
selectively
induce
apoptosis
in
cancer
cells
excluding
healthy
tissues
by
binding
death
receptors
DR4
and
DR5,
are
highly
expressed
various
cells.
Despite
this
promise,
clinical
application
has
been
limited
short
half-life,
stability,
inefficient
sites.
To
overcome
currently
available
engineering
approaches,
a
series
sophisticated
strategies
required:
(a)
design
biomaterial-mediated
carriers
enhanced
targeting
efficacy,
particularly
via
optimizing
selected
materials,
composition,
formulation,
surface
modulation.
Moreover,
(b)
development
genetically
modified
cellular
products
augmented
secretion
toward
microenvironments
(c)
cell
techniques
immobilization
onto
infusible
populations
also
discussed
present
review.
Among
these
living
cell-based
offer
distinct
advantage
systemically
administered
TRAIL-functionalized
capturing
circulating
bloodstream,
thereby
preventing
secondary
formation.
This
review
provides
insight
into
novel
platforms,
discusses
considerations
translation,
suggests
future
directions
complementary
advance
field
TRAIL-based
therapeutics.
Precision Nanomedicine,
Journal Year:
2023,
Volume and Issue:
6(2)
Published: July 7, 2023
In
this
study,
we
review
the
synthesis
of
copper
nanoparticles
(CuNPs)
and
their
prospective
uses
as
antioxidants,
antimicrobials,
anticancer
agents
in
pharmaceutical
sector.
Copper
could
be
created
through
a
variety
methods,
including
chemical
reduction,
green
synthesis,
physical
electrochemical
deposition,
microemulsion
method.
These
methods
make
it
possible
to
precisely
create
with
necessary
shapes,
sizes,
surface
properties,
which
turn
affect
how
well
they
perform
biologically.
CuNPs
have
strong
antioxidant
properties
because
can
scavenge
reactive
oxygen
species
(ROS)
prevent
oxidative
damage.
addition
show
antibacterial
activity
against
number
microbes,
bacteria,
fungi,
viruses.
The
potential
an
agent
has
also
been
extensively
investigated.
toxic
effects
on
cancer
cell
lines
by
inducing
apoptosis,
inhibiting
proliferation,
preventing
tumour
angiogenesis.
Because
specific
toxicity
towards
cells
while
protecting
normal
cells,
provide
fascinating
for
tailored
therapy
overcome
multidrug
resistance.
studied
relation
usage
medications.
They
may
utilised
improve
drug
delivery
systems,
wound
healing,
diagnostic
imaging,
immunotherapy,
anti-inflammatory
effects.
used
stability,
bioavailability,
controlled
release.
More
research
is
needed
ensure
safety,
enhance
processes,
explore
full
therapeutic
situations
